Talk:CREB

CREB haplotypes
are there different human variations(haplotypes)of CREB, CREB has recently been published as being a large part of the longevity producing effect of calorie restriction. Perhaps different human versions of CREB are linked to different human longevity patterns.

functionality of cre
I removed the line regarding the increasing/decreasing the expression of CRE dependent genes. CREB influences the transcription, but there are many, many downstream events involved in expression.Rambrown (talk) 22:42, 21 January 2010 (UTC)

question
this is confusing i see definitions used differently since last time i read, or maybe another confusion

i could easily be wrong but...

last time i read about genes id they were identifying the (staircase) sequence (showing only characteristic inners) after assembly (cell splitting) (each length a chromozones, sets of chromosones a total genome sequence)

and gene expression - well the article HAD said that many lengths or runs in the staircase had not yet been identified (lack of time) and furthermore it was a question why certain areas expressed their coding in protien making sometimes and others not (such as during gestation), while the gene itself remained unchanged

this article makes unclear if CREB is a protien during gene splitting/reproduction (protiens binding) or if it is in solution (or bond) with the gene after (and thus before splitting) (or rather, during normal protient production between)

if CREB is one of many protiens in the factory used during splitting, then the article is NEWLY unclear and does not cite it - and then also the diagram is wrong

back to point rather this article assumes gene expression is certainly a function of surrounding protiens during protien productin (which is ongoing) and not a fuction of gene coding or result of protien production that causes it

so, back to gene expression, by saying CREB is a separate protient created in the nucleus not recursively by direction of the genes, you imply presence or non-presence of CREB causes gene expression, not that the gene which is part of the protient factory control

this would not explain how CREB was present in the nucleus unless manufactured outside and brought in (manufactured by the citric cycle outside nucleus)

on the other hand: it could mean that while CREB is present during the lengthy protient bonding and rebondings: it is a by-product created during it, not the "cause of gene expression"

so. it seems the choice is that they are part of protient production that self regulates (not previously called gene expression - since the question was why with the same gene sequence the effect is not always produced or if you will factorized) or from the citric cycle

two definitions

the new "3d model" makes it very unclear when and how creb is ever part of protient production (if it's during transcription, the 3d model certainly appears to be quite after that is FINISHED). is it 3d art? 3d art should not be confused or used as 3d atomic models

thank you

rephrased
so to the above question. it was previously my understanding the citric cycle protient production was not completely know, neither was the total protient production process the gene (maybe transcription excluded, but parts of that as well), and also there was carbon filiaments and contaminants and the living organisms inside the cell. so, it could not be excluded. thus "gene expression" i had thought was previously defined as known gene sequences that for no know reason expressed themselves conditionaly, but that the exact nature of the self regulating (or destructive) factor was simply not yet known. does a cell become which kind of mutagen, and why was it observed a same gene sequence not have the same effect in two different bodies or at the same time - all KNOWN factors being the same. "gene expression"