Talk:Ca2+/calmodulin-dependent protein kinase II

Changing Title to just CaMKII
The entire article right now is almost solely about CaMKII. Changing the title to CaMKII instead of CaMK would make the page less confusing. —Preceding unsigned comment added by 152.3.68.7 (talk) 03:39, 25 April 2011 (UTC)


 * I agree with you on that one. I was kind of confused by the tittle too Rincrate (talk) 04:33, 29 September 2015 (UTC)

Decreased activity instead of increased/elongated activity
I'm studying for my psychopathology course at the moment, and I'm reading that the effects of CaMKII autophosphorilation contribute to les CaMKII activity through irreversible inactivation of the enzyme and/or less afinity of CaMKII for the Post Synaptic Density (PSD), in this case leading to a reduction in hippocampal plasticity and LTP. I'm not a neuroscientist/biochemist yet, but doesn't this contradict the statement on the wiki-page, claiming higher CaMKII activity after autophosphorilation? My course materials we're compiled and in certain cases written by M. Joëls, professor at the University of Amsterdam, with numerous publications specializing in hippocampal functions. —Preceding unsigned comment added by 145.116.1.128 (talk) 23:29, 22 April 2008 (UTC)

MK2
Confused by some names for MK2: Is CamKII also known as MK2, and if so, is this the same as MAPKAPK2? — Preceding unsigned comment added by 148.177.1.211 (talk) 18:47, 18 April 2016 (UTC)

Last part on CaMKII four isoforms alpha to delta
"CaMK2D[edit] CaMK2D appears in both neuronal and non-neuronal cell types. It is characterized particularly in many tumor cells, such as a variety of pancreatic, leukemic, breast and other tumor cells.[35] found that CaMK2D is downregulated in human tumor cells."

This is confusing. First, the reference (35) is on CaMK2B(beta), not delta (D)! Second, in the reference (35), there is not really mentioning of CaMK2B being downregulated in tumor cells. — Preceding unsigned comment added by 155.91.45.236 (talk) 16:53, 7 June 2017 (UTC)