Talk:Calmodulin

Untitled
"Calmodulin (CaM) is a ubiquitous..." "CaM is expressed in many cell types.." Phrases are redundant; however, it may be more informative to state CaM is expressed in all eukaryotic cells, not just many cell types.

Enzymic activity is inhibited by binding of immunophilin ligand complex (immunophilin alone does not bind) and therefore may play a part in the mechanism of action of cyclosporin A and FK506. Thought also to be involved in the control of sperm motility


 * I removed the above because it was not clear what enzyme(s) this sentence was meant to refer to and how it's relevant to calmodulin. -- Marj 18:32 Feb 23, 2003 (UTC)

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 14:17, 9 November 2007 (UTC)

Prospective edits
Hello, I am looking to make some edits to this Wikipedia page and would love any feedback or suggestions that you think might be helpful.

First, I want to add information to the general section, giving a bit better introduction to what Calmodulin is and why it is important, why it is a good secondary messenger etc. (without creating redundancies between the introduction and the rest of the article).

I would also like to use Pymol or another structure generating program to create images that depict the overall globular structure of calmodulin and indicate where the N-terminus, C-terminus and 4 calcium binding sites are located as well as where it would bind to other larger molecules etc. I would also like to create two images side to side as a visual representation of the conformational changes in the alpha helices EF hand motif, and how that effects the binding of target proteins. And I would like to add some discussion on how exposing hydrophobic regions plays a role in its binding of target proteins.

Another important change that I would like to make is to add sections about the importance of calmodulin in specific physiological systems such as muscle contraction, long-term synaptic potentiation (short-term/long-term memory), metabolism, inflammation, apoptosis, intracellular movements, and immune response. These sections will have details about the way the calmodulin plays a role in specific bodily functions and what other molecules it interacts with during these processes.

Thank you! Anordquist (talk) 22:47, 9 February 2016 (UTC)

In terms of using Pymol, have you considered using Chimera for the conformational changes? I specifically think about how calmodulin is affected by lead in it's conformations.Honestbean (talk) 02:49, 28 January 2018 (UTC)

Caps
Why the capitalised letters in the names of proteins (calmodulin, troponin C etc.)? — Preceding unsigned comment added by Marmio (talk • contribs) 20:30, 4 February 2017 (UTC)
 * Conventional naming of subtypes. Klbrain (talk) 08:38, 6 January 2019 (UTC)

Changes to "structure" and "mechanism" sections
I just rewrote the "structure" and "mechanism" sections. Irrelevant text has been removed, the section has been shortened, and many references have been added. I kept the images the same for now but might go back and upload different ones later. WeirdNAnnoyed (talk) 16:47, 28 July 2020 (UTC)

And I just cleaned up the reference list; due to edits to the sections above there were many redundant entries. WeirdNAnnoyed (talk) 23:24, 14 August 2020 (UTC)

Calmodulin-like protein
Would it be apt to include a section about calmodulin-like proteins and their role in recent research, as some references include how this alludes to their role? Alexniy (talk) 02:55, 26 April 2024 (UTC)


 * I think that would be appropriate, as long as length doesn't get to be too much. If these other proteins are the subject of significant research, they should have their own articles and be linked to this one.  But a short section might be a good idea. WeirdNAnnoyed (talk) 14:12, 26 April 2024 (UTC)