Talk:Carbamazepine/Archive 1

Reference
I tried to find the Schindler reference. Anyone seen it? JFW | T@lk  15:31, 24 October 2005 (UTC)


 * The paper you want is


 * Schindler, W. and Häfliger, F.: Über derivate des iminodibenzyls. Helv. Chim. Acta, 37, 472-483, 1954.


 * See the book "Drug Discovery: A Casebook and Analysis" by Robert A. Maxwell, Shohreh B. Eckhard. This was found using books.google.com.
 * --Colin 23:01, 21 November 2005 (UTC)

Colin, you're great. Thanks for that. JFW | T@lk  00:51, 22 November 2005 (UTC)

Is carbamazepine more effective in treating Herpes Zoster pain or Amitryptaline?

Side Effects
"loss of platelets" is described in this article as both a "Common" side-effect and a "very rare" side-effect. It cannot be both, so which is it? --Colin Angus Mackay 12:33, 30 Mar 2005 (UTC)

According to the FDA labelling information (PDF) for Carbamazepine, loss of platelets is not listed as "most common" side-effect. A loss of platelets and/or white blood cells is said to be not uncommon, but the FDA lacks data on the more severe medical conditions of aplastic anemia and leukopenia, which are associated with decreased blood cell counts. I'll revise the article accordingly. -- Heath 66.32.1.24 06:49, 2 January 2006 (UTC)

I saw the auditory side effect mentioned in the article. About 10 years ago, I was on Tegretol for a few months for treatment of PTSD and depression (or whatever the psych doctor said I had) and I too noticed a difference in the pitch of numerous sounds. It was very hard to describe, but it was very noticeable to me. Has there ever been any research or other information brought up on possible causes of that particular side effect?
 * —Preceding unsigned comment added by Infinitrium (talk • contribs) 06:58, 6 July 2006

hazard codes
Hazard Codes Xn Risk Statements 22-42/43 Safety Statements 22-36/37/39 http://www.sigmaaldrich.com IUPAC:[5H-Dibenz[b,f]Azepine-5-Carboxamid]? log KOW 2.45 vaporpressure 1.84E-007 mm Hg at 25°C Löslichkeit in Wasser 17.7 mg/L

also seems to work at the voltage-gated ca+-channels [Rauth C. (2003): Stabilität von 99mTc-HMPAO: experimentelle Studien und Implikationen für die Epilepsie-Diagnostik] — Preceding unsigned comment added by 84.58.53.144 (talk • contribs) 08:16, 9 May 2007 (UTC)

Interactions
Carbamazepine blood levels may be increased by verapamil, as well as by many other drugs, leading to possible toxicity. The Pill Book

My doctor proscribed verapamil, knowing that I was taking carbamazepine, and didn't warn me. I got weak, sick to the stomach for days; fried by UV rays (carbamazepine is photosensitizing); had double vision (I think because of dried out eyes); and nearly collapsed at work. Thank God for the Internet.

--OldMountainGoat 05:01, 3 June 2007 (UTC)

Effects on GABA?
The article mentions this drug's sodium channel effects, but according to a psychiatrist friend, it also has potent effects on GABA in the body (similar to gabapentin/Neurontin, he says), which apparently increases its efficacy as a mood stabilizer. Does anyone know specifically what those effects are, and could that information be added to the article? I submit that more people would be interested in the drug's effects on GABA, than explanations about sodium channels. Kel - Ex-web.god 13:02, 26 October 2007 (UTC)

Gabapentin
I'm taking 300mg of Gabapentin 3 times a day. I was just put on a low dose (100mg twice a day) of Tegretol. I am on 3 other psychotropics, but was concerned about the interaction of the two mentioned. Anyone have a hypothesis as to the effect? Zralphrocks (talk) 06:49, 4 April 2009 (UTC)
 * There are no significant pharmacokinetic interactions between carbamazepine and gabapentin. Please remember that Wikipedia is not a source of medical advice. Talk to your physician or pharmacist if you have any questions about drug interactions. Fvasconcellos (t·c) 14:15, 3 May 2009 (UTC)

Folic acid and carbamazepine in pregnancy
Under adverse effects, advice is given on giving pregnant women who take Carbamazepine to take folate (folic acid). Folate should be taken by pregnant women regardless of use of carbamazepine, however the drug's tetrogenicity is independent of the folate pathway so folate supplements have absolutely no effect on carbamazepine induced tetragenicity --Ukiedukie (talk) 03:26, 3 May 2009 (UTC)
 * Are you sure? Carbamazepine has an established antifolate effect, and studies have suggested a protective effect of folic acid supplementation . I'm aware of the prospective study publishes in the latest issue of JNNP, but I don't have access to the full text. If you have a source supporting the assertion that "folate supplements have absolutely no effect on carbamazepine induced teratogenicity", I'd really like to see it :) Best, Fvasconcellos (t·c) 14:10, 3 May 2009 (UTC)

Have looked at several older studies which suggest protective effect of folate in certain birth deformaties. However, overall studies have not shown solid evidence for this. The JNNP journal article that you quoted itself states that folate doesn't affect outcome of neural tube defects in epileptic women on this drug. It also quoted a paper : http://content.nejm.org.ezproxy2.library.usyd.edu.au/cgi/content/abstract/343/22/1608?ijkey=695723d3336ecf2fa9add8a0dd91aea9065a74c2&keytype2=tf_ipsecsha stating that drugs including carbamazepine influence folate absorption. Hence, taking more folate isn't of much use if it can't get into the areas where it is needed. Here is a paper in which the results state folate supplements inefficiency.

http://www.seizure-journal.com/article/S1059-1311(99)90283-2/abstract

Sorry for the very late reply, have been busy with work and checking back on this slipped my mind--Ukiedukie (talk) 12:19, 1 June 2009 (UTC)

another side effect
An uncommon but well-documented side effect of Carbamazapine is impaired thyroid function and bradycardia (slow metabolic function and abnormally slow heart rate). Standard treatment in severe cases is surgical implantation of a pacemaker although scientific reports suggest that replacement of Carbamazapine by an alternative anticonvulsent can alleviate symptoms within 24 hours. The manufacturers state that they do not give information about cariac side effects to members of the general public. Fortunately scientific journals are not so retiscent.

User: Med 52 Med 52 (talk) 19:59, 9 March 2010 (UTC)

personal
My Dad, 68, suffered immense pain from trigeminal neuralgia (an extreme jaw pain condition) and used carbamazepine to stop the pain for 3 years without knowing that he had to check for side effects. We all found out suddenly when he developed milofibrosis (hardening of platelets in the bone marrow) when he got weaker and weaker due to his body not producing blood. His trigeminal neuralgia pain is now eased by taking 2 300mg tablets of dom-gabapentin a day which numbs the side of his face. It has been about a year since he stopped taking the carbamazepine, but he is now still unable to produce his own blood and needs blood once a week. He has just started taking predisone (a steroid commonly known to increase blood glucose levels). Hoping his bone marrow will grow back or somewhat detoxify/heal. It's a bad way to live so I hope this helps you with similar condition and am open to any experiences/info you may want to share. Jesse, March 30, 2009. UPDATE-The predisone hasn't had much effect other than to make his abdomen swell so he's being weaned off that. He's getting blood twice a week now. Jesse, May 16, 2009.

Borderline Personality Disorder Treatment using Carbamazepine
Beneficial effects were found for the mood stabilisers valproate semisodium (divalproex sodium), lamotrigine and topiramate, but not for carbamazepine. and — Preceding unsigned comment added by 130.238.163.175 (talk) 17:32, 18 March 2013 (UTC)

Interaction between Doxycycline and Carbazepine
source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1610633/

Seems very important for some Lyme patients ant other.

''The mean half life of doxycycline given to seven patients on long-term diphenylhydantoin treatment was 7·2 ± 0·4 hours. In five patients on long-term carbamazepine treatment the half life was 8·4 ± 1·4 hours. In four patients on combined diphenylhydantoin and carbamazepine treatment the half life was 7·4 ± 0·7 hours. All these were significantly shorter than a mean half life of 15·1 ± 1·0 hours when doxycycline was given to nine control patients. Therefore doxycycline in normal doses given to patients taking diphenylhydantoin or carbamazepine may fail to maintain the minimum inhibitory concentration necessary for proper bacteriostasis. When doxycycline is given in association with agents known to induce drug metabolism the serum concentration of the antibiotic should be watched to see that bacteriostatic levels are maintained.'' — Preceding unsigned comment added by 178.42.121.171 (talk • contribs) 19:44, 30 August 2013‎ (UTC)

Pharmacologist hacker zone
The carbamazepines act not only as ion channels blockers, but also as neurotransmitters releasing agents:

http://www.ncbi.nlm.nih.gov/pubmed/9776325 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1572811/

http://www.ncbi.nlm.nih.gov/pubmed/22735246

The FDA provides with warnings (about effects which may be explained with the serotonin release model together with ion channels block): http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm100190.htm

79.20.9.3 (talk) 22:25, 30 June 2013 (UTC) 79.31.235.99 (talk) 11:13, 31 March 2014 (UTC) VICVONWIKVIT (talk) 13:13, 15 September 2014 (UTC)