Talk:Central tolerance

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle64.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:06, 16 January 2022 (UTC)

Untitled
On merge with central tolerance: I don't think so. At the moment it looks attractive simply because both are stubs. But if there was a decent coverage of this topic then immune tolerance would be a massive article (with 30 000 peer-reviewed articles written on it, the topic is huge and varied). I think immune tolerance should basically remain an overview article, with links to the specific forms of immune tolerance, such as central tolerance, negative selection, regulatory T cell conversion, oral tolerance, etc etc). Sad mouse 16:10, 13 December 2006 (UTC)

Expansion
Seeing as the proposed merger with Immune tolerance failed a while back, this article needs to be expanded to include the intricate detail. Otherwise it will be redundant, duplicating information in the immune tolerance article.

I don't think I have the expertise in this area to do it, I think we need an expert! Snellios (talk) 18:21, 18 May 2008 (UTC)

External links modified
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External links modified
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Some suggestions for improving this page:
 * The history in the beginning of this article is interesting, however, it may be more beneficial to create a History heading and move the history content there.
 * The information seemed relevant, however more research should be done to confirm this.
 * A major flaw in this article is the lack of citations throughout the page. The facts are not referenced appropriately.
 * There should be research done on the genetic diseases that are caused by deficits in any aspects of central tolerance and added to the appropriate section.
 * There are a variety of blanket statements made that are not cited and therefore be removed.
 * The first reference does not work. However, the other references seem to be high quality scientific articles and are focused on the topic overall.
 * Since the suggestion to edit this page has been present since 2011, and has not been removed, there has probably been advancements in central tolerance and probably more know today- this can be investigated by researching the literature.
 * Additionally, it would be helpful to look into how immunology textbooks present central tolerance and also to develop a better understanding of what central tolerance is prior to editing this page.
 * This article requires cleanup, but does not say why.. I believe it's due to the lack of citations on this Wiki page. It is part of the WikiProject :Medicine as well so any edits should take the Manual for medicine-related articles into account and ensure that they are based on reliable sources.
 * There is a general lack of conversation and input on the talk page as well.
 * One important question that needs to be addressed by this Wiki page is the difference between immune tolerance and central tolerance and if these variances need to be addressed.

Immcarle64 (talk) 03:20, 14 January 2018 (UTC)

Please find a list of 7 sources on central tolerance below.
 * Kuraoka, Masayuki; Holl, T. Matt; Liao, Dongmei; Womble, Mandy; Cain, Derek W.; Reynolds, Alexander E.; Kelsoe, Garnett (2011-07-12). "Activation-induced cytidine deaminase mediates central tolerance in B cells". Proceedings of the National Academy of Sciences of the United States of America. 108 (28): 11560–11565. doi:10.1073/pnas.1102571108. ISSN 0027-8424. PMC 3136303 Freely accessible..
 * Goodnow, Christopher C.; Adelstein, Stephen; Basten, Antony (1990). "The Need for Central and Peripheral Tolerance in the B Cell Repertoire". Science. 248 (4961): 1373–1379.
 * Goodnow, Christopher C.; Sprent, Jonathon; Groth, Barbara Fazekas de St; Vinuesa, Carola G. (2005-06-01). "Cellular and genetic mechanisms of self tolerance and autoimmunity". Nature. 435 (7042): 590–597. doi:10.1038/nature03724.
 * Sprent, Jonathan; Kishimoto, Hidehiro (2001). "The Thymus and Central Tolerance". Philosophical Transactions: Biological Sciences. 356 (1409): 609–616.
 * "Back to Central Tolerance". Immunity. 20 (5): 509–516. 2004-05-01. doi:10.1016/S1074-7613(04)00111-6. ISSN 1074-7613.
 * Parijs, Luk Van; Abbas, Abul K. (1998-04-10). "Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off". Science. 280 (5361): 243–248. doi:10.1126/science.280.5361.243. ISSN 0036-8075..
 * A., Owen, Judith (2013). Kuby immunology. Punt, Jenni., Stranford, Sharon A., Jones, Patricia P., Kuby, Janis. (7th ed ed.). New York: W.H. Freeman. ISBN 9781429219198. OCLC 820117219.

Immcarle64 (talk) 23:43, 26 January 2018 (UTC)

I added a section to the beginning of the article to provide readers with a general overview of central tolerance, an idea of why it is necessary/ the function it plays for the immune system, and what can occur if it malfunctions. Please let me know if you have any concerns regarding the content.

Immcarle64 (talk) 04:54, 7 February 2018 (UTC)

Hi all, I edited this page extensively to improve the organization, ensure the accuracy of the information, and add citations throughout. While I was sure to use the original information as a framework for the page, I had to restructure and rewrite many of the sentences either due to them being worded in a confusing way or lacking research supported information. I hope you find this page has met all wikipedia standards and provides a straight-forward yet through explaination of central tolerance.

Immcarle64 (talk) 21:24, 7 March 2018 (UTC)

Positive T cell selection figure incorrect?
As far as I have understood Thymic Epithelial Cells can express only self antigens (see below), so where would this "immunogenic antigen" come for the positive selection? I guess the idea is that if T cell cannot bind MHC at all (no matter what antigen it presents) it will not be positively selected. Cheers, H

Thymic Epithelial Cells Annual Review of Immunology

Vol. 35:85-118 (Volume publication date April 2017) First published online as a Review in Advance on February 10, 2017 https://doi.org/10.1146/annurev-immunol-051116-052320

Thymic Positive Selection Following pre-TCR signaling, DN T cell progenitors proliferate and differentiate to generate a large pool of cortex-resident double-positive (DP) thymocytes. These cells have a short, 3- to 4-day lifespan rescued by αβTCR signaling caused by interactions with self-peptide/MHC complexes on cTECs. This process of positive selection generates both MHC class I–restricted CD8+ and MHC class II–restricted CD4+ cells that migrate out of the cortex and enter the medulla (Figure 4a). The properties that enable cTECs to support positive selection are still only partly understood. However, several studies have identified cTEC-expressed genes involved in controlling the processing and presentation of self-antigens, indicating cTEC specialization involves provision of a particular self-peptide array. For example, unlike most other cells, cTECs display constitutive autophagy activity, a process that results in the degradation of intracellular proteins (Figure 4a). In some experimental settings, the intrathymic generation of CD4+ SP thymocytes was altered in Atg5−/− thymus transplants compared to wild-type grafts, suggesting a role for autophagy in cTECs during the intrathymic selection of CD4+ T cells (96). In contrast, although expression of the endocytic receptor CD205 also defines cTECs, thymic selection occurs normally in CD205-deficient Ly75−/− mice (97), indicating that its putative role in the uptake of apoptotic thymocytes as a source of self-antigens is not required. — Preceding unsigned comment added by 149.203.250.229 (talk) 17:04, 16 April 2018 (UTC)