Talk:Chemoreceptor

Chemoreceptor resetting
Would it be worth having a section on how the baseline rate of action potentials from chemoreceptors changes from the foetus to the neonate? This is well-studied in the scientific literature,  and may be relevant to Sudden infant death syndrome. I'm not sure where to start in adding this content to the article. Bibeyjj (talk) 16:11, 29 December 2020 (UTC)

I would say "no". All 3 publications are primary research, and the conclusions are speculative and unencyclopedic. Zefr (talk) 17:12, 29 December 2020 (UTC)

Gasoreceptor

 * Specific text to be added or removed: Recently, the term gasoreceptor for protein-based chemoreceptors that can directly bind to gaseous signaling molecules and trigger cellular signaling was proposed. However, this term is not widely used in the scientific literature. Examples of gasoreceptor includes C. elegans molecular O2 receptor guanylyl cyclase GCY-35 and molecular CO2 receptors guanylyl cyclase GCY-9.


 * Reason for the change: Gasoreceptor is a new term for protein-based receptors that can bind and sense gaseous molecule. This term will allow to distinguish between chemoreceptor cells vs protein-based gasoreceptors.
 * References supporting change:

Zebrafishgroup (talk) 13:20, 21 January 2024 (UTC)


 * The Anbalagan article is not a WP:SCIRS review, but an opinion about a hypothetical receptor. Chemoreceptors like the carotid or aortic sinuses can actually be identified anatomically, and resected for experimental or clinical purposes. Gasoreceptors exist as a theoretical concept. The argument for a physical cellular entity is not convincing, as there could be other ways a gas evokes a cellular response, such as a change in partial pressure or enzyme sensitivity, neither of which requires a receptor. Zefr (talk) 18:24, 21 January 2024 (UTC)
 * Soluble guanylyl cyclase is the protein gasoreceptor for nitric oxide. Gasoreceptor is not an hypothetical or theoritcal term. It is a new classification for protein-based receptors that can bind and sense gas in a cell. 31.0.176.28 (talk) 18:45, 21 January 2024 (UTC)
 * likewise in C. elegans GCY35 is the molecular oxygen sensor, a protein gasoreceptor. The moderator is not aware of the literature cited in the Anbalagan manuscript. 31.0.176.28 (talk) 19:18, 21 January 2024 (UTC)
 * Under WP:BURDEN, it is the responsibility of an editor to provide a reputable review to support content. The concept of a gasoreceptor is in development. Advocates for the concept appear to be using Wikipedia to report preliminary research, countering WP:NOTJOURNAL #6-7. Zefr (talk) 19:58, 21 January 2024 (UTC)
 * The text has been revised and secondary references has been added for receptors for O2 and CO2. Zebrafishgroup (talk) 21:50, 21 January 2024 (UTC)
 * The Anbalagan article is a "perspectives" discussion (see top of page in AJP), i.e., a statement of an hypothesis, and is in press as of this date, i.e., not published. The Carillo article is primary research in a lab model animal. A rigorous review and further evidence of this hypothetical concept by an independent source are needed.
 * Further, as Zebrafishgroup has declared a conflict of interest, no further editing of this or related articles about this concept should occur without first obtaining consensus on the respective talk page, WP:CON. Zefr (talk) 22:36, 21 January 2024 (UTC)
 * Carillo article is a review article and not a primary research.
 * Gas sensing in nematodes.
 * Carrillo MA, Hallem EA.Mol Neurobiol. 2015;51(3):919-31. doi: 10.1007/s12035-014-8748-z. Epub 2014 Jun 8.PMID: 24906953 Review.
 * Gasoreceptor is not  an hypothetical concept. Zebrafishgroup (talk) 22:44, 21 January 2024 (UTC)
 * The author approved version of the manuscript is already published online in AJP journal. Zebrafishgroup (talk) 22:46, 21 January 2024 (UTC)
 * A draft for a gasoreceptor article has been denied by an administrator, with the comments Savani Anbalagan is the only author that used this term. Until other people from other groups publish on this topic as well, it is not shown to be notable. There is probably not enough publication for it to get a a Wiktionary entry.
 * Other draft articles on gas-related chemoreceptors composed by Zebrafishgroup have also been rejected as non-notable, unsupported by SCIRS reviews, and "unambiguous advertising or promotion: self written vanity", WP:COI. We can end this discussion now. Zefr (talk) 17:48, 22 January 2024 (UTC)
 * In light of the above discussion, it seems that inclusion of this novel concept is premature.  WhinyTheYounger ※ Talk 16:49, 27 January 2024 (UTC)