Talk:Chloral hydrate/Archive 1

GHB
What is with the moralistic non-footnote about GHB? Not that I have qualms, or wish to malign a well intending vigilante author, but this is an encyclopaedia and that is absolutely inappropriate. Raise ire on the GHB page. 71.232.31.175 (talk) 05:29, 30 September 2008 (UTC)

I deleted a recipe for home made chloral hydrate. I'd be happy to discuss it but it is hard for me to imagine any use for that formula that would not endanger some one. Alteripse 20:54, 23 Jun 2004 (UTC)
 * In any case, Wikipedia is not a cookbook! Physchim62 16:07, 16 Jun 2005 (UTC)


 * I really think that something should be done about the fact that the article provides information both on chloral and chloral hydrate. I have a suspicion that as chloral hydrate is formed by a reaction with water (e.g. bodily water (?)), the two forms listed are from a medical standpoint mutable. I will however provide a graphic differentiating the structure of the two forms. I will refrain from making any real modifications to the article as I am not an expert. Snarfevs 07:18, 19 October 2005 (UTC)

Approval for use
The article states: Chloral hydrate has not been approved by the FDA in the United States or the EMA in the European Union for any medical indication and is on the list of unapproved drugs that is still prescribed by clinicians.[10] Usage of the drug as a sedative or hypnotic may carry some risk given the lack of clinical trials.

This is not correct. Working in medicine I used this often and there are a number of references to it being available, commercially, for prescribing use. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682201.html http://www.drugs.com/ppa/chloral-hydrate.html

The reference applies to the US. The claims about the EU are unsubstantiated. In the case of the UK, most certainly incorrect.

I will leave the entry as it is and ask for comments. surfingus (talk) 08:55, 24 October 2014 (UTC)

Chloral Hydrate lab found on property. Questions.
Maybe one of you can help me. A relative of mine purchased some mountain property that had what looked to be the remains of an old Meth Lab on it. We had the property cleaned out and in the process came across a recipe for "Knock Out Drops" or Chloral Hydrate. Sure enough, all of the needed equipment had been there to produce that particular drug. Compelling evidence was also found that meth was made there. My question is, are the two drugs often used or sold together? Is the Chloral Hydrate used to reduce the anxiety brought on by the meth? I can't figure out why these guys went to such elaborate lengths to make Chloral Hydrate- as this seems to have been the main drug they were making. And, yes my mind has wandered to the more sinister scenario of these hillbillies buying local women drinks at the bars, slipping them "Mickies" then dragging them back to the cabin...  I'm hoping they were just selling the stuff since there was so much equipment and so many vials and small jars. Any thoughts?

Im wondering if anyone can tell me how much of it you would have to take for it to kill you..my grandmother died of overdose.123.3.1.82 03:04, 28 March 2007 (UTC)ac

Structural formula
Isn't the Chloral Hydrate structural formula supposed to have an extra hydrogen at the 1 position, like the Chloral one? —The preceding unsigned comment was added by 12.41.204.3 (talk • contribs) 18:28, 21 June 2006.

In organic structural formulas, hydrogen atoms bound to carbon are implicit (see Structural formula: "line drawings of structural formula are assumed to have carbon atoms at the vertices and termini of all line segments not marked with the atomic symbol of an element (other than carbon). Each carbon atom is in turn assumed to bear enough hydrogen atoms to give the carbon atom four bonds.") 193.217.163.93 11:09, 7 October 2006 (UTC)

The formulae match those in PubChem - Chloral and Chloral hydrate. Colin°Talk 22:27, 28 June 2006 (UTC)

Except that PubChem's drawing does not pretend to be 3-dimensional. Since Wiki's drawing shows C2 as tetrahedral, C1 should also be shown as tetrahedral and the -OH pointing up should be shown either in front of or behind the plane of the drawing. Dirac66 19:05, 28 October 2007 (UTC) ==

Trivia
I have moved the following section here because it contains non-encyclopedic trivia and completely lacks any context (which makes iit hard to determine notability), see WP:TRIVIA. Cacycle (talk) 17:15, 28 November 2008 (UTC)

Chloral hydrate in fiction and film

 * Bram Stoker, "Dracula," 1897
 * Edith Wharton, "The House of Mirth." New York, C. Schribner’s Sons, 1905.
 * Evelyn Waugh, Vile Bodies. London, Chapman & Hall Ltd., 1930.
 * Margery Allingham, "The Case of the Late Pig." Hodder & Stoughton, 1937.
 * Agatha Christie, "And Then There Were None." Dodd, Mead and Company, 1940.
 * Rex Stout, "The Final Deduction," Chapter 7. Viking Press, 1961.
 * From Russia with Love, movie, 1963.
 * Roger Zelazny, "Lord of Light", 1967.
 * Jimmy Breslin, "The Gang That Couldn't Shoot Straight," 1969.
 * Larry Gelbart, "M*A*S*H*" TV-Series, Season 3, 1974.
 * The Living Daylights, movie, 1987.
 * Caleb Carr, "The Alienist." Random House, 1994.
 * Sarah Waters, Affinity. London: Virago Press, 1999.
 * Oz, TV-Series, Multiple episodes,(Handicap used by Ryan O'Reilly)
 * David Shore, "House M.D." TV-Series, Season 1, 2004.
 * The Venture Brothers, TV-Series, Season 1, Episode 4, 2004
 * Taxi Driver, Martin Scorsese, Travis is offered this by gun dealer
 * Thomas Pynchon, Against the Day, London, Vintage Books, 2007.
 * Joanne Harris, Sleep Pale Sister, Black Swan 2004.
 * I would put it back. The only reason I visited this page was because of the citation in Bram Stoker's Dracula. -- Evertype·✆ 15:50, 20 April 2016 (UTC)

Conversion to Trichloroethanol
>>it is metabolized within 4 minutes into trichloroethanol by erythrocytes and plasma esterases<< Esterases can't do that, I guess, because it's a reduction. --FK1954 (talk) 19:21, 17 April 2010 (UTC)

External links modified
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 * Added archive https://web.archive.org/20120511075531/http://www.justice.gov/dea///concern/chloral_hydrate.html to http://www.justice.gov/dea/concern/chloral_hydrate.html

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Bram Stoker's chloral
Bram Stoker gives the formula not as C₂H₃Cl₃O₂, but as C₂HCl₃O·H₂O. What's the difference? Just notation? -- Evertype·✆ 15:49, 20 April 2016 (UTC)

unsourced derivatives section
unsourced content added here


 * Derivatives


 * 1) Amfecloral
 * 2) Chloral betaine, a related drug
 * 3) Cloracetadol (bonded with paracetamol).
 * 4) Cloxestradiol
 * 5) Cloxotestosterone
 * 6) Dicloralurea (growth stimulant for animals)

-- Jytdog (talk) 20:28, 12 June 2016 (UTC)

External links modified
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Unsourced 1
from the Notable uses section - moving here per WP:PRESERVE: -- Jytdog (talk) 18:16, 2 December 2016 (UTC)
 * Jennie Bosschieter (1882–1900) who was murdered with chloral hydrate in Paterson, New Jersey on 12 October 1900.
 * William S. Burroughs (1914-1997) was expelled from school for experimenting with chloral hydrate along with another pupil. The incident is detailed in the writer's foreword to Junkie.
 * Mary Todd Lincoln was given chloral hydrate for sleep problems. See Mary Todd Lincoln by Jean Baker and Mary: Mrs. A. Lincoln, by Janis Cooke Newman.
 * Dante Gabriel Rossetti (1828–1882), the English painter, was a regular user of chloral hydrate, originally against insomnia. He is quoted as saying to his friend Hall Caine: "Everyone has skeletons in their cupboards, and this is mine."

Unsourced 2
Moving here per PRESERVE:

Derivatives Derivatives of chloral hydrate include:
 * Amfecloral, an appetite suppressant drug
 * Chloral betaine, a sedative drug
 * Cloracetadol, a prodrug of paracetamol
 * Cloxestradiol, a synthetic estrogen
 * Cloxotestosterone, a synthetic steroid
 * Dicloralurea, a growth stimulant for animals
 * Mecloralurea, an anxiolytic drug
 * Butonate, an anthelminthic drug
 * Plifenate, an insecticide
 * Chloralodol, a sedative drug
 * Chloralose

-- Jytdog (talk) 18:17, 2 December 2016 (UTC)

Ld50 for what?
In the article, it mentions the LD50 for vapor inhalation of 440mg/m3/4 hours. Is this in humans? If so, how was this found? Otherwise, in which animal was this tested? — Preceding unsigned comment added by 2001:8004:15A0:1065:25FF:A734:A51B:C6B4 (talk) 08:19, 22 June 2020 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Bretsilverglate. Peer reviewers: AlecWild.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 08:41, 18 January 2022 (UTC)

Which is correct: "a LD50" or "an LD50"?
First of all, the basic part: I've slightly modified the phrasing of the "Safety" section. I changed "the vapors" to "its vapors" — while perfectly acceptable on grammatical grounds, the construction "the vapors/vapours" brings to mind the archaic medical diagnosis with the same name. I don't foresee this edit being contentious, but please feel free to revert it if I have missed something.

Now, this is the part I'm not so sure about: I changed "a LD50" to "an LD50". This feels intuitively correct to me, because the initialism "LD", when spoken aloud, begins with a vowel sound. But I have no idea whether this is a genuine grammatical convention, or whether Wikipedia favours a particular form in these contexts. I suspect the phrase "a/an LD50" must come up fairly often in articles about drugs, toxins, etc. My question, then, is this:

Where an initialism begins with a consonant character, but is pronounced with a word-initial vowel sound, is there a consensus as to which form of the indefinite article is preferred by Wikipedia? Foxmilder (talk) 06:41, 2 September 2023 (UTC)