Talk:Cinnarizine

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as stub, and the rating on other projects was brought up to Stub class. BetacommandBot 07:52, 10 November 2007 (UTC)

Structure Stereochemistry
various sources linked off this page suggest the stereo is E- as shown here: http://www.chemspider.com/Chemical-Structure.1264793.html. What is the source of info (other than PubChem) suggesting it is E/Z?--ChemSpiderMan (talk) 04:59, 24 September 2008 (UTC)

Unless backed up by evidence, I will change the structure to trans (by end of november 2009), because there is hard scientific evidence for it, see Acta Crystallographica B (1975), B31, 1495. I was confused by the structural inaccuracy myself (and it's drawn in an unusual way, in my opinion). Necmon (talk) 21:06, 2 November 2009 (UTC)

Reason for non availability in North America
Is there a particular reason why Cinnarizine is not available in the US/Canada? Mandolamus (talk) 17:57, 25 December 2010 (UTC)

Does anyone know the worst-case LD50 dose?
This is also a response on to why Cinnarizine is not available in the US: because the potential benefits are GREATLY outweighted by potential damage.

As the article states, cinnarizine is a CNS depressant, that is, it has antihistaminic, antiserotonergic, antidopaminergic effects. How strong, you ask? Strong enough not to be approved. One example: the usual dosage is supposed to be 2-3 tablets a day. Here I will describe effects on a test subject at a dose of 2 tablets a day.

Day0: Very active in a product design and development, producing drawings and text. Day1: 1 tablet in the afternoon, moderate effect, "nothing serious". Day2: 1 tablet in the morning, 1 in the afternoon. Unusual sleepiness, loss of vigour, sleeping at the work desk. Day3: 1 tablet in the morning, slept all day in a state of depression Thus the dosage ended. Some recovery took 30 days, during the time subject claimed utter inability or motivation to work, in a state of constant low-grade agony, dragging his left arm, total memory loss of work done at Day0 and the weeks/months before, "had to study my own work to partly understand what was meant by it". After 60-90 days still not recognizing some people he has known in the years before (infrequently met people).

Thus the question is: what is the LD50 of this thing? What is the best case and worst case lethal dose? Obviously, it can cause CNS depression, which at one point may very well become lethal. The question of why is this even prescribed to "improve blood flow" is beyond me. — Preceding unsigned comment added by 90.64.57.202 (talk) 10:28, 20 April 2017 (UTC)

Side effects list?
I don't know whether to copy the content in the leaflet that I have, but it lists suicide as a possible side-effect. — Preceding unsigned comment added by 90.64.7.200 (talk) 10:38, 18 November 2019 (UTC)

Conflation of Parkinson's disease and Parkinsonism
Hello

I am not an editor however am a medical doctor with some expertise in this area. I wanted to point out that this article conflates Parkinson's disease and parkinsonism. Parkinsonism is a collection of symptoms that can be caused by parkinson's disease, other diseases or medications.

Parkinson's disease is a specific neurological pathological process. Taking antihistamines doesn't increase the chances of getting it. They can just mimic the symptoms (or worsen them in those who already have PD)

If you read the sources that are referenced in this article you will see that they support this position. 82.45.8.196 (talk) 18:45, 7 January 2022 (UTC)