Talk:Citicoline

ADHD
Important topic missing. — Preceding unsigned comment added by 174.88.11.188 (talk) 19:56, 1 July 2014 (UTC)

--- The article referenced in relation to citicholine does not say that preliminary research supports use in ADHD. The interview subject says it has been suggested (with no reference to a source) that it could be used to treat ADHD. — Preceding unsigned comment added by 27.99.65.126 (talk) 03:48, 20 March 2016 (UTC)
 * A PubMed search on citicoline and attention deficit did not yield any published literature on attention deficit disorders. A search at clinicaltrials.gov did not yield any ongoing research on this topic, either. Based on my and the 2016 comment, removed any mention of ADHD.David notMD (talk) 12:40, 9 March 2017 (UTC)

CDP-choline for patients with multiple sclerosis
Although funding seems to be the major hurtle in this research project, remyelination could be achieved with CDP-choline (experiments show some benefits). — Preceding unsigned comment added by Don Rosenberger (talk • contribs) 22:18, 18 August 2016 (UTC)
 * Reference following explores the theory of CDP-choline for MS, but there are no published clinical trials on this topic. The search site clinicaltrials.gov does not list any ongoing research in this area either.David notMD (talk) 12:34, 9 March 2017 (UTC)

Skripuletz T, Manzel A, et al. Pivotal role of choline metabolites in remyelination. Brain. 2015 Feb;138(Pt 2):398-413.

Vision literature
As of March 2017, this is what is in the article: "Citicoline improves visual function in patients with glaucoma [18] and may improve amblyopia("lazy eye") when combined with eye patch treatment.[19]" Ref #18 is a review. Ref #19 is a clinical trial. There are no published reviews - the preferred type of reference - for citicoline and amblyopia. The quality of literature is not strong - the cited ref, for example, was not a blinded trial, and some of the trials it cites are quite old. Someone more expert in treatment of amblyopia may decide that it is premature to include citicoline as a treatment.David notMD (talk) 12:59, 6 March 2017 (UTC)
 * After asking opinion of more experienced W editor, removed amblyopia mention entirely. The American Academy of Opthamology (2015) refers to this as an emerging treatment concept, with further studies needed.David notMD (talk) 12:14, 9 March 2017 (UTC)

Medical uses - removals and reference upgrades
Removed mention of citicoline for appetite satiety and improving blood flow, as the references were to one uncontrolled human trial and animal work, respectively. Removed mention of amblyopia because only a few clinical trials, some weak or old, and no good review. Replaced references for glaucoma, memory and stroke with secondary sources (reviews, systemic reviews, meta-analyses).David notMD (talk) 12:28, 9 March 2017 (UTC)

Memory and Cognition
I hesitate to edit this article because I have no background in this area, but I just noticed something that seems obviously wrong. The article states, "Studies have failed to confirm any potential benefits of citicoline for cognitive impairment," and then it goes on to cite an article that seems to me to state the exact opposite. — Preceding unsigned comment added by Hirschjoshua (talk • contribs) 20:16, 12 February 2022 (UTC)


 * I second that. This article used for reference here expresses completely opposite results 109.78.161.125 (talk) 20:42, 10 February 2023 (UTC)