Talk:Citrulline

Ball and Stick Model is incorrect
The carboxylamine (alpha amino group, ie. -CH(NH3)COOH) nitrogen has too many hydrogen. The hydrogen shown should belong to the carboxyl oxygen (-COOH). The formula associated is correct. DAY medmatix 21:07, 23 November 2018 (UTC)medmatix


 * Was this ever fixed? 173.88.246.138 (talk) 23:35, 30 May 2022 (UTC)

Side effects of supplement
I was wondering taking 1-citrulline as a supplement, is there any side affects? —Preceding unsigned comment added by AngelaFood (talk • contribs) 1 August 2006

Other fruit sources
Other Sources of Citrulline: I was wondering what are some other fruit that contain high amounts of citrulline? —Preceding unsigned comment added by 70.139.72.193 (talk) 23:14, 5 August 2008 (UTC)

What is an "idealized formula"?
What is an "idealized formula"?HowardJWilk (talk) 22:25, 2 August 2013 (UTC)
 * ✅ Good catch.  Probably me or someone writing in obscure academic language where things are correct but no one can understand the point.  I changed it. --Smokefoot (talk) 23:33, 2 August 2013 (UTC)

Citrulline and erectile dysfunction
I remove content in Sources about citrulline in watermelon rind and possibility that it could benefit erectile dysfunction. There is one valid clinical trial on that question, but in the absence of any other research, premature to link citrulline (or watermelon) to treating erectile dysfunction. TRIAL: Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology. 2011 Jan;77(1):119-22. . David notMD (talk) 02:37, 23 December 2016 (UTC)

Citrulline malate as athletic performance supplement
The article cites Bendahan 2008 as preliminary research. Since then there have been six more clinical trials published, five with positive results (Perez-Guisado, Wax, Wax, Glenn, Glenn) and one with no benefit (Cunniffe). Unfortunately, there are no published secondary sources (systemic reviews or meta-analyses). The dose range for the seven trials was 6 to 12 grams. Bendahan was the only trial that looked at multi-day consumption (15 days). The design for the others was all testing 60 minutes after consumption of a single dose. All seven trials were placebo controlled. Until there is a good published review it is probably premature to post all this in the Article. Hence, here. David notMD (talk) 02:55, 23 December 2016 (UTC) 1.	Bendahan D, Mattei JP, et al. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med 2002;36:282-289. PMID:12145119 2.	Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PMID:20386132 3.	Cunniffe B, Papageorgiou M, et al. Acute citrulline-malate supplementation and high-intensity cycling performance. J Strength Cond Res. 2016;30(9):2638-47. 4.	Wax B, Kavazis AN, Weldon K, Sperlak J. Effects of supplemental citrulline malate ingestion during repeated bouts of lower-body exercise in advanced weightlifters. J Strength Cond Res. 2015;29(3):786-792. PMID:25226311 5.	Wax B, Kavazis AN, Luckett W. Effects of supplemental citrulline-malate ingestion on blood lactate, cardiovascular dynamics, and resistance exercise performance in trained males. J Diet Suppl. 2016;13(3):269-282. PMID:25674699 6.	Glenn JM, Gray M, et al. Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players. Eur J Sport Sci. 2016;16(8):1095-103.	. 7.	Glenn JM, Gray M, et al. Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr. 2015 (in press).