Talk:Classical complement pathway

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Jo.wong.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 19:08, 17 January 2022 (UTC)

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Immcarle22.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:47, 16 January 2022 (UTC)

Untitled
This should be merged with the Complement (biology) article.

Figure 1 is also inaccurate, it shows classical C3 convertase as C4bC2b rather than C4bC2a. The text and Figure 2 both state this correctly. — Preceding unsigned comment added by 72.178.155.98 (talk) 20:12, 1 May 2016 (UTC)
 * Fixed the errors in Figure 1--Jo.wong (talk) 20:00, 4 August 2017 (UTC)

The diagram uses C2a, which the lead in states is "historical." Though this is explained in the lead in, it may cause confusion.

Should the lead in be edited to match the diagram? Or vice versa (though it looks here as though the diagram was already edited to use C2a).

This is confusing to me - a user who was just reading the article to make sense of how the drug Soliris works on myasthenia gravis. Mangofirst (talk) 23:56, 4 April 2020 (UTC)

Context and standard English
Please explain what the complement's classical pathway does functionally in the body that's different from the other two pathways. Why are there three pathways? Please add a brief introduction that a serious lay reader could understand about why there are three pathways and why this one is important in the functioning the complement system. Thanks. Eperotao (talk) 17:54, 20 June 2014 (UTC)

PS. This article should be described as related to the Immune System (not just blood). Eperotao (talk) 17:55, 20 June 2014 (UTC)

PPS. Imagine describing all the parts of a washing machine, including the parts of the water pump and the clutch mechanism that allows it to spin without ever mentioning that it is used to wash clothes and how a person would do that. That's how a lot of the molecular entries at Wikipedia read. Please take a step back and give lay readers some context, not just a parts list. Eperotao (talk) 18:01, 20 June 2014 (UTC)

New Suggested Lead In For Article
(Advice is welcome!)

The Classical Complement Pathway function as a part of the complement system and leads to complement activation via the binding of Antibodies to Antigen. Both the IgM and IgG antibody isotypes are capable of initiating complement activation. This initiation step then leads to the recruitment of other proteins in order to form the C3 convertase protein complex. C3-convertase hydrolyzes C3 resulting in signal amplification and further complement activation. The following steps in the pathway are similar to those initiated by the lectin pathway and alternative complement pathway. C3b binding results in further signal amplification and cleavage of C5, which leads to the formation of the Complement membrane attack complex, eventually forming a pore in the membrane of the target and inducing cell lysis and death.Immcarle22 (talk) 19:12, 10 February 2016 (UTC)


 * Overall it's a pretty solid lead, most of which mirrors the current Overview section of the article. The Overview section should probably be removed and replace the lead of the article.--Jo.wong (talk) 07:29, 4 August 2017 (UTC)