Talk:Clomipramine

Clomipramine effectivity
It would seem that Clomipramine is substantially more effective than Paroxetine and Citalopram. See the following studies:

https://www.sciencedirect.com/science/article/abs/pii/016503279090081I

https://www.ncbi.nlm.nih.gov/pubmed/2876451

--2A04:4540:7014:6A00:490B:D59:989C:1C80 (talk) 19:48, 23 January 2020 (UTC)

Clomipramine in brain cancer fight
Clomipramine might be effective in treating brain cancer...

should definitely be added / mentioned: http://www.bbc.com/news/health-29440314

here another link: http://uopnews.port.ac.uk/2016/10/25/old-drug-could-provide-cancer-breakthrough/

and yet another: https://theconversation.com/how-an-old-antidepressant-could-provide-the-next-brain-cancer-breakthrough-67346

..... https://www.canceractive.com/cancer-active-page-link.aspx?n=1096&title=Using-Clomipramine-to-treat-brain-tumours

--77.186.78.33 (talk) 21:34, 2 May 2018 (UTC)

Price
The article says it costs 1.20 a day for a typical dose. This is outdated information as there's recently been a huge spike in the price. My 100mg/day prescription was hundreds of dollars for one month.

Yes, I got sticker shock today in filling my first prescription. I've updated the price quote.128.187.112.7 (talk) —Preceding undated comment added 18:59, 8 February 2018 (UTC)

Needs Stronger Cautions Re: Anticholinergic Effects
This article needs significant cleanup in relationship to the side effect issues of clomipramine. First of all, like many of the older tricyclics, this is a potent anticholinergic drug. It is grossly inadequate to suggest that "confusion" (an intrinsically vague term) is a caution. In any patient with a confusional state, or with any version of baseline dementia (and these never should be conflated as the author appears to do here), the administration of an anticholinergic drugs should be seen as strongly contraindicated. Indeed there is now emerging evidence that anticholinergic drugs are a risk factor for the induction of Alzheimer's disease when given over the long-term to an elderly population. This drug, therefore, probably should not be used in the elderly at all, especially when there are so many alternatives that do not suffer this serious downside of potent cholinergic blockade. We have an epidemic of iatrogenic confusional states in the elderly from anticholinergic medicines, in large part because people are simply naïve about the risks of anticholinergic drugs. This piece should not contribute to that naïveté. 76.24.52.9 (talk) 13:39, 26 April 2010 (UTC) DF Watt Harvard Medical School

Doesn't this just seem like instructions taken off a bottle of Clomipramine?
I think it would probably read better if it was in the style of some of the other articles on psychiatric drugs. Gershwinrb

My cat has cognitive dysfunction syndrome
I'm wondering why this line "Clomipramine has been used for cognitive dysfunction syndrome to alleviate anxiety associated with the disease; however it is not believed to manage the underlying cause of the problem." is in the veterinary use section of the article. —Preceding unsigned comment added by 24.90.108.139 (talk) 15:27, 15 April 2009 (UTC)

Yeah I agree
It needs to be Wikipediafied or not....

I agree and have tried to make an improved version. Please check and give me your comments. Thank you.

/+ shouldn't OCD be on the top of indications? really, it's very, very, very rarely used for depression --Lieutenant Colonel Frank Slade 03:05, 10 July 2006 (UTC)

''In Australia AMI use it in Nasal delivery form for premature ejaculation. Is this use widespread?''

Inadvertent Orgasm From Yawning?
Seriously? That's not vandalism?

134.173.58.89 (talk) 04:05, 4 April 2009 (UTC)
 * It's not vandalism. The article does need to be wikified, though, i.e. this needs to be given a lot more prominence. 69.203.73.99 (talk) 21:40, 8 June 2009 (UTC)


 * In fact, it can be cited here  — Preceding unsigned comment added by 2601:D:CA00:DF0:1C56:D9C7:F4A:35A8 (talk) 00:23, 30 October 2014 (UTC)
 * What about The Canadian Journal of Psychiatry is it that disqualifies it from being a reliable source?-- Auric    talk  16:14, 15 February 2015 (UTC)

Re-added. It's not vandalism, it's citable to a major psychiatric journal. Please don't remove it again unless you have good cause to impeach the credibility of the article, such as other articles explicitly contradicting it.

Truth is stranger than fiction, after all. —70.44.112.7 (talk) 00:40, 24 February 2016 (UTC)


 * That old source is not WP:MEDRS-compliant. Reverted. Show me some good medical sources that state that orgasms are caused by yawning, and/or as a side effect of clomipramine while yawning. Flyer22 Reborn (talk) 03:15, 26 February 2016 (UTC)

use with brain tumours
There is a significant amount of research into the use of Clomipramine on brain tumours- while the results aren't yet conclusive, they are important and it would be sensible if this was properly mentioned here. see eg http://www.canceractive.com/cancer-active-page-link.aspx?n=1096 — Preceding unsigned comment added by 92.40.180.112 (talk) 18:16, 28 August 2011 (UTC)


 * I agree! It should be added / mentioned!
 * --77.186.78.33 (talk) 21:35, 2 May 2018 (UTC)

External links modified
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Side effects list (Diarrhoea)
What source is being used for the catagorisation of side effects because Diarrhoea appears in both the Common (1–10% frequency) and Very rare (<0.01% frequency) categories? It cannot be both! Bluedalmatian (talk) 14:03, 1 October 2023 (UTC)