Talk:Cocaine intoxication

Seroquel, being a dopamine receptor antagonist (and therefore effectively reduce the agonism from the reuptake obstruction and increased agonism of the dopamine receptors by the dopamine caught up trapped in the synapse by the cocaine molecule blocking their reuptake out of the synapse), would be the perfect antidote. You'd think a journal or such would have suggested this as a potential perfect 'cure' for cocaine "overdose". The quetiapine article states: atypical antipsychotics have sometimes been used to "come down" off cocaine or amphetamines. and that much makes sense. However strangely, though classed as a dopamine recepor antagonist (and in that respect should do for dopaminergic drugs what naloxone/narcan does for opiates/opioids), seroquel technically dissociates dopamine receptors in such a way to move dopamine to potentially safer dopamenergic pathways, the purely pleasurable ones and not the tachycardic ones, because it is receationally used with cocaine too (called a "Q-ball"). So it maybe potentiates and protects from overdose as well? 65.102.21.129 (talk) 06:56, 22 March 2010 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 17 August 2019 and 11 December 2019. Further details are available on the course page. Student editor(s): Samcattrano, Averygcraig, Daniel Journey. Peer reviewers: Larne2019, BoNeApPlEtEa42.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 17:55, 16 January 2022 (UTC)

I'm not sure about this...
"In cases where a patient is unable or unwilling to seek medical attention, cocaine overdoses resulting in mild-moderate tachycardia (i.e.: a resting pulse greater than 120 bpm), may be initially treated with 20 mg of orally administered diazepam or equivalent benzodiazepine (e.g.: 2 mg lorazepam). Acetaminophen and physical cooling may likewise be used to reduce mild hyperthermia (<39 C). However, a history of high blood pressure or cardiac problems puts the patient at high risk of cardiac arrest or stroke, and requires immediate medical treatment. Similarly, if benzodiazepine sedation fails to reduce heart rate or body temperatures fails to lower, professional intervention is necessary.[3][4][5]"

This section of the lead seems to me to be providing medical advice to cocaine users who slightly overdose but don't want to seek medical attention. Given how easy it would be to change those numbers around, I don't really think it should be included (especially considering it's unsourced). I have removed that section and appended the following to the preceding paragraph:

"In addition, a history of high blood pressure or cardiac problems puts the patient at high risk of cardiac arrest or stroke, and requires immediate medical treatment."

Please discuss here before reverting or modifying this change, since this seems to be very iffy information to include. Regards, MacMedtalk stalk 02:40, 6 May 2011 (UTC)

Pyrogen
I don't think cocaine should be called a pyrogen as per the definition on the linked wikipedia article. — Preceding unsigned comment added by 31.7.16.214 (talk) 06:18, 6 April 2012 (UTC)

What is the subject of this article?
In accordance to its title (Cocaine intoxication) this article should focus on Cocaine chronic effects due to habitual use and on the adverse effects due to severe acute intoxication (overdose). I'm pretty sure that the section about withdrawal is out of scope and that it should be removed, except for a few phrases that might be recycled into other sections (e.g., "Management"). I'm interested to know what other contributors think about this issue. Fabio Maria De Francesco (talk) 22:31, 2 August 2020 (UTC)