Talk:Coeliac disease

Neuropsychiatric comorbidities associated with Celiac Disease
I see the "Miscellaneous" section has a one-liner about "depression, anxiety, and other mental health disorders" being related to CD. That's the one and only time neurological and psychological comorbidities of CD is mentioned. I'm hoping to create a section that directly addresses this.

Although the relationship between CD and various conditions such as cerebellar ataxia, peripheral neuropathy, seizures, headaches, cognitive impairments, depression, anxiety, Autism Spectrum Disorder (ASD), bipolar disorder (BD), schizophrenia, eating disorders (ED), and attention deficit hyperactivity disorder (ADHD) are not fully understood, there is published literature suggesting a relationship exists with at least some of these conditions.

Some areas I'd discuss:


 * 1) CD is a disposing factor for many neuropsychiatric disorders, perhaps due to the shared biological processes and networks associated with the GI system and the brain
 * 2) Impacts of diagnosis and gluten-free diet on quality of life (QOL)
 * 3) Importance of the gut microbiota in better understanding gluten digestion and its neurological manifestations
 * 4) Elevated rates of social anxiety have been noted among CD patients

Please let me know if there's anything I can add to make this as comprehensive as possible. Happy to field any questions or concerns. Any other reputable sources I should reference?

Sources:

Alkhiari R. (2023). Psychiatric and Neurological Manifestations of Celiac Disease in Adults. Cureus, 15(3), e35712. https://doi.org/10.7759/cureus.35712

Giuffrè, M., Gazzin, S., Zoratti, C., Llido, J. P., Lanza, G., Tiribelli, C., & Moretti, R. (2022). Celiac Disease and Neurological Manifestations: From Gluten to Neuroinflammation. International Journal of Molecular Sciences, 23(24), 15564. https://doi.org/10.3390/ijms232415564

Hansen, S., Osler, M., Sanne Marie Thysen, Rumessen, J. J., Linneberg, A., & Line Lund Kårhus. (2023). Celiac disease and risk of neuropsychiatric disorders: A nationwide cohort study. Acta Psychiatrica Scandinavica, 148(1), 60–70. https://doi.org/10.1111/acps.13554

Lebwohl, B., Haggård, L., Emilsson, L., Söderling, J., Roelstraete, B., Butwicka, A., Green, P. H. R., & Ludvigsson, J. F. (2021). Psychiatric Disorders in Patients With a Diagnosis of Celiac Disease During Childhood From 1973 to 2016. Clinical Gastroenterology and Hepatology, 19(10), 2093-2101.e13. https://doi.org/10.1016/j.cgh.2020.08.018

Zingone, F., Swift, G. L., Card, T. R., Sanders, D. S., Ludvigsson, J. F., & Bai, J. C. (2014). Psychological morbidity of celiac disease: A review of the literature. United European Gastroenterology Journal, 3(2), 136–145. https://doi.org/10.1177/2050640614560786

Atopperkroog (talk) 15:16, 30 April 2024 (UTC)