Talk:Coumestrol

Unclear sentence
This sentence is not understandable or grammatical: "Pueraria mirifica (White Kawo Krua) has been found to contain concentration of coumestrol where Cu2+ at 1000 ppm the highest concentration was to be found where CuCl2, MnCl2 and FeCl2 at 1,000 ppm can in fact stimulate coumestrol accumulation.[citation needed]" —Preceding unsigned comment added by 173.164.52.242 (talk) 04:59, 28 January 2011 (UTC)
 * I have removed the sentence because it does not make any sense. -- Ed (Edgar181) 12:13, 17 June 2011 (UTC)

Potential References
This article is being edited as part of an assignment regarding environmental disruptors of development. Below is a list of potential sources which we may use in editing this article. If any of the following sources don't seem suitable, or if there are other sources which we failed to include which would be useful, we would be grateful for that feedback. We will be working in AELie515's sandbox

Potential Sources:

Intake of Dietary Phytoestrogens by Dutch Women

Breast cancer cell apoptosis with phytoestrogens dependent on estrogen-deprived state

Neurobehavioral actions of coumestrol and related isoflavonoids in rodents

Phytoestrogens for menopausal vasomotor symptoms

Phytoestrogens and Human Health Effects: Weighing up the Current Evidence

Coumestrol induces mitochondrial biogenesis by activating Sirt1 in cultured skeletal muscle cells.

Coumestrol treatment prevents Na+, K+ -ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia.

Phytoestrogens levels determination in the cord blood from Malaysia rural and urban populations

Genotoxicity of phytoestrogens.

AELie515 (talk) 16:37, 17 February 2015 (UTC)
 * Please talk to your teacher (or another professional) about literature searchers. Wikipedia aims for articles founded on secondary sources, per the guideline WP:SECONDARY.  Here are some reviews published on this topic since 20000:


 * Gawel, E., Grzelak, M., "Protein from lucerne in animals supplement diet", J. Food, Agric. Environ. 2014, 12, 314.
 * Ndebele, K., Graham, B., Tchounwou, P., "Estrogenic activity and molecular mechanisms of coumestrol-induced biological effects", Food Nutr. Compon. Focus 2013, 5, 518.
 * Seidlova-Wuttke, D., Jarry, H., Wuttke, W., "Plant derived alternatives for hormone replacement therapy (HRT)", Horm. Mol. Biol. Clin. Invest. 2013, 16, 35. 10.1515/hmbci-2013-0024
 * Liu, M. M., Huang, Y., Wang, J., "Developing phytoestrogens for breast cancer prevention", Anti-Cancer Agents Med. Chem. 2012, 12, 1306.
 * Prakash, D., Gupta, C., "Role of phytoestrogens as nutraceuticals in human health", Pharmacologyonline 2011, 510.
 * Hendrich, S., "Phytoestrogens and phytosterols", Woodhead Publ. Ser. Food Sci., Technol. Nutr. 2009, 170, 437. 10.1201/9781439829158.ch17
 * Prince, R., Muchmore, D. B., Siris, E. S., Estrogen analogues: selective estrogen receptor modulators and phytoestrogens, 2008, 1705.
 * Karkola, S., Lilienkampf, A., Wahala, K., "Phytoestrogens in drug discovery for controlling steroid biosynthesis", Recent Adv. Polyphenol Res. 2008, 1, 293. 10.1002/9781444302400.ch13
 * Maruyama, T., "Authentication and chemical analysis in the regulation of natural products", Foods Food Ingredients J. Jpn. 2007, 212, 374. ; j Krishna, D. R., Somashekhar, M., Pharmacokinetics of phytoestrogens, 2006, 99.
 * Whitten, P. L., Patisaul, H. B., Young, L. J., "Neurobehavioral actions of coumestrol and related isoflavonoids in rodents", Neurotoxicol. Teratol. 2002, 24, 47. 10.1016/S0892-0362(01)00192-1
 * If you need advice, especially on chemical topics, feel free to ask.--Smokefoot (talk) 14:24, 18 February 2015 (UTC)
 * We have looked at most of those sources and verified that they are review articles so unless you find some that aren't, please assume that we have indeed asked our professor about sources we should be using. We will make sure that all of the sources we end up using are secondary sources when we start editing. Thanks for the help and all the additional sources!

--Hwola (talk) 18:08, 18 February 2015 (UTC)

Summary of Intended Changes
We intend to expand the information presented in this article and organize it into sections. These will include a section containing the background information already presented in the article, including the natural sources of coumesterol and its chemical properties. We will also be adding a section including its biological effects, including those related to the nervous system, those related to the reproductive system, fertility, and development, and possibly those related to metabolism. We also intend to include a section regarding the current studies of its potential impact, both positive and negative, on health issues such as breast cancer and menopause.

AELie515 (talk) 03:39, 23 February 2015 (UTC)