Talk:Creatine kinase

Untitled
Creatine Kinase levels are also tested in children with inherited disorders of skeletal muscle such as dystrophies. I think one might want to add a section on this...

Myoglubin is an other word for Creatine Kinase, yes or no?? Who wants to give an answer? By Mfg

Reply to the above query: No, myoglobin is definitely not creatine kinase. The former is present on the surface (cell membrane) of skeletal muscle fibers (particularly, the "slow" fibers imparting a pinkish hue in the process) and helps "trap" oxygen for these fibers. This molecule is like hemoglobin in that it too contains the iron-containing heme group, but with this important difference that each molecule of the latter contains four molecules of heme instead of one (present in myoglobin). Hopefully, this should clear your doubt. --KC Panchal 21:55, 5 February 2007 (UTC)

Thermodynamic feasibility of conversion of creatine to phosphocreatine
I got this doubt reading the 25th edition Harper's Biochemistry (the latest is the 26th edition), which I couldn't get resolved even after searching on the Internet including Wikipedia. There is a mitochondrial creatine kinase (miCK) present between the inner & outer mitochondrial membranes, which phosphorylates creatine to phosphocreatine at the cost of an ATP molecule (ATP-->ADP), which is exported out the mitochondrion through the pore protein 'P' (pages 147-148). What is the need for such an enzyme if any way cytosolic creatine kinase can carry out the same reaction? My guess, is that it must be faster to transport phosphocreatine out of the mitochondrion than ATP, but I do not know for sure (as such a thing is not WRITTEN in the text); then, once in the cytosol, the phosphocreatine must be getting converted back to creatine, phosphorylating ADP to ATP in the process. But, an even bigger doubt is how id the reaction creatine-->phosphocreatine (requiring 43.1 kJ/mol) thermodynamically feasible if ATP-->ADP releases only 30.5 kJ/mol (page 126; table 12-1)? Looking forward to replies--answers/guesses/just about anything. KC Panchal 11:57, 5 February 2007 (UTC)

Image of creatine kinase?
What is that image of creatine kinase? It sure is colorful...what kind of micrograph is that? Anykind.. —Preceding unsigned comment added by 64.72.65.162 (talk) 03:22, 14 October 2008 (UTC)


 * Here are some articles that give the background of the picture
 * http://science.nasa.gov/newhome/headlines/msad14jan98_2.htm - main article about the Protein Crystal Growth Program.
 * http://science.nasa.gov/newhome/headlines/dewar_pix/pcg_gallery.htm - gallery of pictures. Many of them are not linked to the hires versions but you can find them via Google on the nasa site.
 * http://spaceflight.nasa.gov/history/shuttle-mir/science/mg/msci619.htm This one has a picture of the creatine kinase crystal. The article is about the first shuttle/MIR mission and says the creatine kinase picture is at 100x magnification.
 * The pictures were taken using polarized light which likely accounts for the colors. --Marc Kupper&#124;talk 09:05, 1 April 2009 (UTC)

Concern about quoted reference range for Creatine Kinase levels
I'm finding the reference range for "normal" creatine kinase levels cited here to be significantly higher than every other medical reference on the web. I just read about someone who'd had two heart attacks and had a serum CK level of 236 U/L, which is well within the cited normal range here, but above the normal range listed in other places, such as this site: http://www.goodhope.org.uk/departments/pathweb/refranges.htm

I can't imagine those editing Wikipedia would want others dying from myocardial infarction because they read here that their CK level was normal.

I'm not qualified to state what an appropriate reference range is, but I know enough to know the range listed here is incorrect. —Preceding unsigned comment added by 69.23.90.117 (talk) 00:58, 8 September 2009 (UTC)

Even this page in Wikipedia conflicts with the given normal range here: http://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests  —Preceding unsigned comment added by 69.23.90.117 (talk) 01:10, 8 September 2009 (UTC)

CK-MB
listed in this article is information about CK-MM and CK-BB, with a passing reference to CK-MB. I understand CK-MB to be "myocardial band creatine kinase". Should this be highlighted in the article? --159.178.246.231 (talk) 12:09, 25 October 2010 (UTC)

Sourcing
The sourcing in this article is pretty poor. I just scrubbed a 1969 reference that didn't even have the name of the enzyme in the title. Pubmed has 8625 articles where CK is a "major subject header". 265 of those are reviews. Stangely none of those are a topic-wide review of the enzyme, suggesting that a biochemistry textbook might be more suitable as a "framework/scaffold" source for this article. JFW &#124; T@lk  17:51, 25 May 2014 (UTC)