Talk:Crohn's disease/Archive 3

BBC section
Per MEDRS, we shouldn't be citing news stories - I'll try to track down the actual research tomorrow for this one, see if it is worth including. WLU (t) (c) Wikipedia's rules: simple/complex 02:12, 26 June 2009 (UTC)

Recent research in France has suggested that a shortage of the bacterium Faecalibacterium prausnitzii may cause Crohn's disease by overstimulating the immune system. The researchers said that if ongoing animal trials prove successful, human patients could benefit from a probiotic treatment with F. prausnitzii. However, it was stated "It is too early to tell whether this will lead directly to a new treatment as other probiotics have tended to produce good results in animal studies only to prove disappointing in clinical trial in Crohn's disease."


 * Here are some links I found on it. I am not good at writing this up so I'll just leave the links I gathered so far. ,  and .  Of course I had to put my preferred site for info to easily digest.  There is actually a lot about this out there but to be honest it's almost only at the point of WP:Crystal Ball point since it's a new area being looked at with no final results or definite information about this.  Thoughts? -- Crohnie Gal  Talk  10:56, 26 June 2009 (UTC)


 * I think it is perfectly okay to report new and as yet unproven research in an article, as long as it is prominently marked as being new and unproven, and then removed when it is disproved or superseded. Not all knowledge is equally reliable, but medical and scientific progress depends on having access to all knowledge (just as democracy depends on having access to all points of view). David spector (talk) 21:08, 29 September 2009 (UTC)

Plan for FA
Not too far from FA, and I'd like to start a push to get it there before the end of 2009. Much of the content is there but extensive copy-editing is required in general I think this can be done with a goal of starting WP:FAC in November -- Samir 06:10, 15 October 2009 (UTC)
 * 1) Expansions are needed in epidemiology, prognosis, and history
 * 2) The lead needs to be edited to meet WP:LEAD and alt text needs to be added to images
 * 3) Citations have to be cleaned up
 * 4) A CT scan of terminal ileitis should be rummaged up. I should find one.  I should also find an endo picture of terminal ileitis.

Video playlist for cancer treatment-entry 10 of 31-mentions side effect of treating Crohns
This video entitled cantron ovarian cancer and chrons misspells the word Crohn's because the contributor who grabbed and put online the captured video tape / DVD clip was primarily concered with cancer (that is easier to spell).

- Has anyone mentioned this in the article? - Can this be added to the article even if it is a anecdotal claim? - Has anyone with Crohn's tried this treatment who is not a share and stake holder in the allopathic medicine mindset?

Supposedly, the mechanism of Cantron / Cancell, etc, is that it is a electro-chemical means of metabolically starving anaerobic cells and pathogens. It has a chemically effective half-life of 6-hours and so should be taken in small doses on a fairly frequent basis (much less than every 6 hours). There are supposedly a huge number of conflicting dietary foods that must be avoided, so one lecturer claims that it generally takes about 5 hours to train a potential patient on the care and use of the chemical mixture.

One of the video playlist entries claims that it clears up certain forms of autoimmune diseases. It looks like some of the lectures take place at the Granada Forum in Tarzana California. Oldspammer (talk) 12:10, 25 November 2009 (UTC


 * I did a bit of reading around and there definitely appears to be a relationship between cancer and autoimmune disease. A lot of oncology drugs seem to be effective in autoimmune conditions. Has anyone tried Cyanovirin-N for Crohns yet? — Preceding unsigned comment added by Shtanto (talk • contribs) 16:16, 25 April 2012 (UTC)

MMR vaccine controversy
That article mentions Crohns, but I'm not sure how best to intergate it into this one. Comments/suggestions?  Lugnuts  (talk) 13:26, 3 February 2010 (UTC)
 * Yep, the evidence is lacking and only anti-vaccination rhetoric. Hence, not worthy of including, save in an anti-vaccination article.Wzrd1 (talk) 04:17, 25 January 2012 (UTC)

Image removal
I just want to clarify that there is no copyright problems with the images. As can be seen at the images being deleted lately by anon IP's, the images were uploaded by me and verified by an administator at the commons. I had help with uploading the images. The images are mine and I gave them freely for use in any project. Thanks in advance, -- Crohnie Gal Talk  13:43, 9 February 2010 (UTC)

crohns is not an autoimmune disease
Hi everyone Robbins Pathology 8th edition states specifically that Crohns is not an autoimmune disease, but rather a combination of defect in host epithelium and commensal bacteria. I'm not qualified to correct this page, but someone probably should change the opening paragraph. Robbins is the standard text in the field. —Preceding unsigned comment added by 129.173.192.241 (talk) 13:48, 10 March 2010 (UTC)

hey there! This is not completely true! because IT'S NOT CLEAR if it is not an autoimmune disease! Many genomic loci which seam to play an important role in Crohn's disease are also associated with autoimmune diseases! I haven't read the book you are referring to, but are there any publications which can prove this statement? Most reviews dealing with IBD/Crohn's/or ulcerative colitis, state that nobody really knows but most scientists think that Crohn's might be a mixture out of a common inflammation and an overreaction(=autoimmune) of the hosts immune system.

Just as an example: R. J. Xavier& D. K. Podolsky - Unravelling the pathogenesis of inflammatory bowel disease


 * Not sure who wrote the above but Uptodate states "The immune response has long been implicated in the pathogenesis of inflammatory bowel disease (IBD), including both ulcerative colitis and Crohn's disease. From a vast body of literature investigating the roles of both host and microbial factors, two basic themes in the pathogenesis of IBD emerge [1,2]: Dysregulation of the innate and adaptive immune system directed against luminal bacteria or their products found in the intestinal lumen Inappropriate immune responses to organisms in the intestine that normally do not elicit a response, possibly due to intrinsic alterations in mucosal barrier function" -- Doc James (talk · contribs · email) 10:49, 12 April 2010 (UTC)


 * I've just rewritten the lede to say 'is thought to be an autoimmune'. No need for 'by some', as this (appears to be) the mainstream viewpoint. Perhaps we should also say something along the lines of 'Although the exact cause is not known' as well (this is what the Mayo website's 'causes' section leads with). It would also be useful if the original poster could post the extract from Robbins. --sciencewatcher (talk) 19:57, 12 April 2010 (UTC)


 * The fact that a lot of Crohns sufferers take LDN leads me to believe that it definitely has an immune component. Although LDN is an off-label medication, and only 1 proper study that I'm aware of has looked into it, it helps people with autoimmune disease. Given the benefits of side effect free non-toxic medication, I think it's worth mentioning in the treatment section if adequate references can be found. Shtanto (talk) 16:13, 25 April 2012 (UTC)

Images
An editor again moved all of them to the right which causes problems with large white spaces. I reverted it back to the way they were prior to this. This was discussed previously. Editors agreed that the white space was ugly and that putting some to the left was the way to prevent the white spaces. Comments? -- Crohnie Gal Talk  16:29, 12 April 2010 (UTC)


 * White space? I do not get any white space with firefox.  What browser is this with?  They look significantly better on the right and this is the recommended placement per WP:IMAGE. Doc James  (talk · contribs · email) 16:51, 12 April 2010 (UTC)


 * I use internet explorer and get lots of white spaces with the change you made. I wonder why there is so much of a difference? Another editor WLU made the first move to the right.  -- Crohnie Gal  Talk  17:09, 12 April 2010 (UTC)


 * Yeah, I use IE sometimes too, and it does create lost of whitespace. There is a fix, gimme a sec to look at it.  WLU (t) (c) Wikipedia's rules: simple/complex 17:18, 12 April 2010 (UTC)


 * Nope, normally you can stack them at the top of a section and that addresses the problem but there are too many in the same sections this case. The other work-around is to tweak the image size, location, shape and paragraph/section order to try to line it up, but it only works in some cases (i.e. everyone else has to be using the same browser window size, on the same size monitor, with the text at the same size, and probably a whole bunch of other defaults I don't know about).  This may be a browser-specific - FF is far, far better in general than IE (I never get crashes with FF, which I have to worry about extensively with IE) but it should be dealt with so all browsers are equally functional.
 * The page is also quite image heavy, which doesn't help. I got no suggestions right now, WP:IMAGE might have some ideas, there's a couple templates I've seen used that might help but I'd have to look into it.  WLU (t) (c) Wikipedia's rules: simple/complex 17:31, 12 April 2010 (UTC)


 * Samir had plans to bring this article up to at least GA status. He added a few images as did some others who were going to help in this endeavor to update this article. Unfortunately that has not been done, at least not yet.  I left him a message about the IBD vs IBS stuff, so hopefully he will see all of this stuff that is going on. Samir is a GI.  His comments here would probably be quite useful at this point. -- Crohnie Gal  Talk  19:22, 12 April 2010 (UTC)

The images are gross, especially the one of the guy's zombie leg. Is it really necessary to illustrate this stuff so graphically when it's not the main issue at hand? 85.211.39.50 (talk) 16:55, 31 October 2010 (UTC)

Hatnote
Regards the IBS/IrBD/InBD, David Ruben suggested a hatnote, specifically about. Seems OK to me, any other thoughts? WLU (t) (c) Wikipedia's rules: simple/complex 13:11, 14 April 2010 (UTC)

Missing heritability
Under 'cause' the article states: "The genetic risk factors have now more or less been comprehensively elucidated, making Crohn's disease the first genetically complex disease of which the genetic background has been resolved". This is flat out wrong. The reference attached as 'proof' gives no indication at all that this is true either, instead saying "How many susceptibility genes underlie IBD and how they interact with each other and with environmental factors is not precisely known, but the list of genes and environmental factors is growing almost every month." Current estimates are that we have tracked about 20% of Crohn's heritability and the rest is still to be found (http://hmg.oxfordjournals.org/cgi/content/full/18/R1/R101). There is plenty of room to argue over the exact proportion but none of that makes the genetic factors 'more or less comprehensively elucidated', and this claim needs to be removed.

The next few sentances are also overly broad and simplified, to the point of being meaningless. There is a lot more going on than just 'malfunction' of the innate mmune system and the viewpoint about overactive adaptive response as compensation is one of many unproven ideas (and not the most widely accepted). This whole section needs rewriting by someone who has read and understood the current research. 202.36.134.22 (talk) 22:44, 25 July 2010 (UTC)

Typo in the Surgery section?
First paragraph reads "Crohn's can be cured by surgery,but may be required for complications such as obstructions, fistulas and/or abscesses, or if the disease does not respond to drugs." Shouldn't it read "Crohn's can not be cured by surgery,but surgery may be required for complications such as obstructions, fistulas and/or abscesses, or if the disease does not respond to drugs." It contradicts the table found in the Crohn's vs. Ulcerative Colitis section.


 * You are most certainly right. Crohn's is not curable by surgery--or by any other means, as far as we know... --Silentrebel (talk) 18:43, 25 March 2011 (UTC)

Category for the article List of people diagnosed with Crohn's disease
Hello. The category on List of people diagnosed with Crohn's disease (Lists of people with disabilities) was removed and then I restored it. Is this an appropriate category for this list? Is there an issue with the wording of the category or is there a better category that could be used? Thanks.  Lugnuts  (talk) 08:13, 10 March 2011 (UTC)
 * As the remover, I will give my reasoning for doing so. My contention is that the wording is highly inappropriate, and could be construed as subjective.  Crohn's is a disease, not a disability.  We do not (meaning on WP or otherwise) classify kidney disease or liver disease as a "disability", nor do we classify cerebral palsy or paraplegia as a disease.  That's one part of it.  Similarly, the comment was made that a disability is an "impairment".  It would seem to me that the list of notable people with Crohn's is a list of individuals who are successful in so many different areas and occupations in spite of the condition.  To me, that negates any sort of "impairment", and (having thought of this while typing) in fact, that wording might be a BLP violation -  we are implying that these people are impaired, and they very well may not hold that same viewpoint. MSJapan (talk) 18:15, 10 March 2011 (UTC)

Curb Your Enthusiasm
In the HBO show Curb Your Enthusiasm, Crohn's Disease is mentioned but it's described as a mental disorder similar to ADHD. I doubt that I am the only one who saw one of those episodes and came straight here. —Preceding unsigned comment added by 98.240.237.172 (talk) 02:04, 30 March 2011 (UTC)

A list of references regarding stem cell therapy
Someone recently deleted a passage of text regarding (stem cell therapy +"crohn's disease" Barcelona) without changing the reference to one he/she "likes"... Pick one instead of erasing stuff, and put the info back in the article please: references Oldspammer (talk) 11:53, 12 June 2011 (UTC)
 * This is still really preliminary, ongoing research (a very small study was published in this month's Gut). I'm not sure it belongs in the article just yet. Fvasconcellos (t·c) 18:10, 12 June 2011 (UTC)

Alternative medicine section
The article says "there is no evidence that acupuncture for this purpose has benefits beyond the placebo effect." But both of the referenced articles describe a significant benefit for TCM beyond that of the placebo group, even though the placebo effect is also large. The text is extremely misleading as written. Sorry I am a wikipedia novice or I would change it myself.Gregshap (talk) 20:55, 3 October 2011 (UTC)
 * Updated. Yobol (talk) 20:00, 4 October 2011 (UTC)

At least 75% of this is in no way alternative medicine; it's standard or experimental treatments. The section is therefore highly misleading. 86.179.72.113 (talk) 22:46, 16 August 2011 (UTC)


 * Strikes me that alternative medicine is what doctors didn't think to try. So often, they try to treat the problem rather than the cause of the problem. Labelling a treatment as alternative seems to make it easier to dismiss. Acupuncture helps. Placebos help too. Shtanto (talk) 16:23, 25 April 2012 (UTC)

I would add that a study in the journal "Clinical Gastroenterology and Hepatology" found that medical marijuana caused a complete remission of Chron's disease in 5 of the 11 patients who were given the drug and 5 who's symptoms were cut in half. A total of 21 patients participated in the study. I infer that the 10 patients were given placebo. imnotfat1 (talk) 17:20, 18 May 2013 (PST)

The article appears to overlook a significant area of research. I have no expertise -  everything I'm saying is based on the book  Breaking the Vicious Cycle by Elaine Gottschall, 1986. The reference seems to be appropriate since the author's research for her master's degree was published in Acta Anatomica, 123:178 (1985). I'm putting this in the alternative medicine section since the book is about what the author calls the 'Specific Carbohydrate Diet', a dietary intervention. The author refers on page 2 to, "Over six hundred scientific publications (that) have appeared in medical journals in the 1970's and early 1980's" concerning what's called the Elemental Diet, "an artificial diet, usually administered via a stomach tube," and only effective as long as the diet is continued. The author's Specific Carbohydrate (single sugar carbohydrate) Diet is administered in the home and so is much more practicable. It seems the diet can be terminated at some point after at minimum of one year. It appears that this diet has been very successful in relieving or entirely curing a number of disorders of the GI tract, including Crohn's disease. Thirteen web sites devoted to the issue are listed and there are fourteen pages of references most of which, maybe all of which, are to scientific research articles. ˝˝˝˝

There's a Wiki article on the Specific Carbohydrate Diet which mentions Gottschall's book -  a link could be inserted to this article.

Weak evidence of autoimmune basis
It does not appear the source supports this statement; the authors are postulating a weak initial immune response leading to a prolonged activation subsequently. I'm not seeing where the authors say that the evidence for autoimmunity itself is weak (they just shift the inflammatory response to a different phase of the disease). Am I missing something? Yobol (talk) 14:30, 21 October 2011 (UTC)
 * Agree. Fixed and added another review. -- Doc James (talk · contribs · email) 14:34, 21 October 2011 (UTC)

Update disease name to "Crohn disease" from "Crohn's disease"
There is no "s" in Crohn disease. Robbins and Cotran Pathologic Basis of Disease refers to it as Crohn disease and NOT Crohn's disease. The following link is the best I can provide, as there is no easily accessible online version: http://books.google.com/books?id=mwD5Y0jMUZAC&pg=PT3384&lpg=PT3384&dq=robbins+crohn&source=bl&ots=hXnvjD2fgL&sig=RikrFV6DzCCYSfqA4WjqkvTveJ0&hl=en&ei=Tq_ATrqXGM-DsgKRs8zOBA&sa=X&oi=book_result&ct=result&resnum=1&ved=0CCEQ6AEwAA#v=onepage&q&f=false

Someone please confirm and rename the entire Wiki page. — Preceding unsigned comment added by Rmpatel88 (talk • contribs) 06:05, 14 November 2011 (UTC)


 * You've found one book that spells it this way. There are dozens of reliable sources cited in the article which spell it "Crohn's", and it's spelled like that by the Centers for Disease Control, the Mayo Clinic, and the National Institute of Clinical Excellence. The prevailing policy regarding article titles is Article titles which says "Article titles are based on what reliable English-language sources refer to the article's subject by"; in order to change the article title, we'd need to cite a large body of evidence that "Crohn" is the dominant spelling. -- Finlay McWalterჷTalk 12:19, 14 November 2011 (UTC)

Lifestyle Section
I have some concerns about the lifestyle section. When it says a low dietary fibre diet is followed should it not specify a diet low in insoluble fibre? It is my understanding soluble fibre is fine. I also question the statement in the same lifestyle section that people should avoid milk and diary products because it has been shown to cause Crohn's. The main thrust of this page is that we don't know what causes Crohn's. Either this statement should be removed, or modified to say that it may be a factor in causing the disease in some people.--2ytbal (talk) 18:22, 23 September 2011 (UTC) — Preceding unsigned comment added by 2ytbal (talk • contribs)

To follow up on this: I followed the link in the citation ([105]) which suggests that milk is bad, and I could not find the word "milk" anywhere on that page, or any mention of dairy products. I believe this means we should remove the citation, and perhaps the entire sentence about dairy products. With regards to low dietary fibre diets, I think the main point here is to avoid fibres that are macroscopically sized - things like the strands in aspargus. Microscopically sized fibres, e.g. soluble fibres or the fibre in wholegrain bread which are fine (and good) as far as I know.

Perhaps some additional points to add: anything that acts like glue - e.g. oatmeal with little water in it, or cheap wheat buns you buy at gas stations, is bad. In general, anything that can "become a big object" inside your intestine is bad. This also includes some fruits (like oranges), where it is best to to peel not just the orange, but also the individual boats of the orange and discard these skins as well. AsmundErvik (talk) 12:07, 9 December 2011 (UTC)

What kind of "association" with fat and animal protein is that? Am I blind or did reference 53 really not much more than plot suspected offenders in Japan against cases of Crohn in Japan? The Japanese recently eat more good food and less plants and also have more Crohn. You could probably say in the same way a high GDP or average megapixels per camera are "associated" with Crohn? I can really see no effort to find at least an individual correlation like "fat lovers come often down with crohn", and looking closely, the "correlation" plots go vertical, meaning fat stays the same, crohn still rises (the years are missing, presumably because they would spoil the plots) --88.75.228.242 (talk) 20:46, 10 December 2011 (UTC)

Contributor to lactase deficiency?
According to the "Lactose Intolerance" page on nih.gov (http://digestive.niddk.nih.gov/ddiseases/pubs/lactoseintolerance/) Crohn's disease can result in lactase deficiency. Can anyone confirm this, and should it be added to the article? Purplie (talk) 04:15, 29 December 2011 (UTC)

New research
Hey,

I was searching some news on Crohn Desease and found some intresting articles about the last research from 2011, 2012 - -http://www.sciencedaily.com/releases/2012/03/120319194215.htm -http://www.sciencedaily.com/news/health_medicine/crohn's_disease/ -http://www.sciencedaily.com/releases/2011/10/111031115105.htm

There are some interesting and new facts that could improve this page.

Thank you for your support and the information I can get with your help.

Nick User:83.70.64.118

Marijuana remission
http://www.ladybud.com/2013/05/15/marijuana-put-my-crohns-disease-into-remission-and-its-not-a-joke/ — Preceding unsigned comment added by 178.150.71.168 (talk) 22:33, 20 June 2013 (UTC)

New info, immune system transplant
New information that may be useful here. http://seattletimes.nwsource.com/html/localnews/2018756084_immunetransplant24m.html Ferensen (talk) 19:23, 24 July 2012 (UTC)

New review

 * this article could probably use an update. Yobol (talk) 22:35, 22 January 2013 (UTC)

Can we please remove the link to this now-deleted Category Page?
Given that "Category:Pages with incomplete PMC references" no longer exists, can we please remove the link to it? I don't see the little minus sign that one would normally click on to remove it, so if someone who knows a way around that would get rid of it, that would be awesome! The Mysterious El Willstro (talk) 05:53, 11 March 2013 (UTC)

Edit request on 1 July 2013
"Certain medications can also impact sperm count or may otherwise adversely affect a man's ability to conceive."

The article refers to a man's ability to conceive. A man can NEVER conceive - only women can do that. Please rewrite.

88.96.100.30 (talk) 10:26, 1 July 2013 (UTC)


 * Yes check.svg Done. For the record, the reference led to a dead link, and I have tagged it as such. Rivertorch (talk) 19:38, 10 July 2013 (UTC)

Enterovirus link to Crohn's just discovered
This Crohn's article has a very good section detailing the microbial associations of Crohn's. One new item to be added to these microbial associations is the new findings of an enterovirus link to Crohn's:

This 2013 study found ileocecal Crohn's disease is associated with enterovirus infection (but note that all the study cohort with ileocecal Crohn's disease had disease-associated mutations in either their NOD2 or ATG16L1 genes). Drgao (talk) 21:57, 1 July 2013 (UTC)

Person rather than patient
Per WP:MEDMOS we typically use person rather than patient. This edit reverted some of my efforts to make this article comply with our guideline.

It is sort of like saying that unless someone has received a formal diagnosis and getting treatment for Crohn's (ie they are a patient) they cannot get anemia. Also it is more appropriate to refer to someone as a "person with CD" as we are people first rather than a "patient with CD" or a "CD person" or a "CD patient". Doc James (talk · contribs · email) (if I write on your page reply on mine) 00:56, 15 September 2013 (UTC)

fluoxetine
Lots of ppl, the thing goes away [for a few months] in 1-4 days with 20-60mg fluoxetine(prozac) (and with no other ssri or other antidepresant... [I am one].. some of them [like me] need benzos like nitrazepam to cope with the prozac.. oddly, havent found literature mentioning it... Manojpandeyanarchocommunist (talk) 23:21, 16 February 2014 (UTC)

Reverted
I have reverted this as it does not say "mutations in NOD2 gene causing Crohn's disease" And it is a primary source. Doc James (talk · contribs · email) (if I write on your page reply on mine) 18:57, 17 February 2014 (UTC)
 * The paper is not a suitable source. And even if it was it does not say NOD2 causes CD. What is says is "may contribute to differences in disease susceptibility and prevalence among populations" These are very different. Doc James  (talk · contribs · email) (if I write on your page reply on mine) 21:44, 17 February 2014 (UTC)

Semi-protected edit request on 21 February 2014
Requesting citation regarding surgery not curing Crohns. I was diagnosed with Crohn's; had surgery to remove my large intestine and have had no symptoms for 18 years after numerous definitive tests.

HiroSakuraba (talk) 16:37, 21 February 2014 (UTC)
 * Red information icon with gradient background.svg Not done: The fact that you are in remission, does not mean that the surgery you had is a Cure. — &#123;&#123;U&#124;Technical 13&#125;&#125; (t • e • c) 17:01, 21 February 2014 (UTC)
 * Sounds like ulcerative colitis Doc James  (talk · contribs · email) (if I write on your page reply on mine) 01:59, 12 June 2014 (UTC)

From above
I have some concerns about the lifestyle section. When it says a low dietary fibre diet is followed should it not specify a diet low in insoluble fibre? It is my understanding soluble fibre is fine. I also question the statement in the same lifestyle section that people should avoid milk and diary products because it has been shown to cause Crohn's. The main thrust of this page is that we don't know what causes Crohn's.  Either this statement should be removed, or modified to say that it may be a factor in causing the disease in some people.--2ytbal (talk) 18:22, 23 September 2011 (UTC)
 * Convert lists to prose
 * Add a prognosis section
 * Potentially expand epidemiology section
 * Clean up the treatment section, moving much more to the dedicated article
 * Expand pathology section to actually be pathophysiology with some discussion of proposed mechanisms of action, etc.
 * Reference everything which is not already referenced
 * Thorough copyedit
 * Peer review
 * Expand mention of the possible neurological complications of CD in the extraintestinal symptoms section. Add links to journal papers on this subject and discuss possible causes.
 * Reference trends in treatment - biologics versus antibiotics (European treatment/trends lean towards long term antibiotics), success rates, outcomes and long term treatment prognosis (given the nature of the new treatments).
 * Expand on the bacterial pathogenesis (offering an unbiased critical view on whether or not a cure for Crohn's disease may be out there as was the case with H. Pylori but simply overlooked/ignored by the medical community).

I strongly suggest the title of the article, and all further references to the disease within the article, be changed from Crohn's disease to Crohn disease. The disease was named after one of the pathologists who first described the condition, he did not have the disease himself, which is what having the "'s" added to the end of the last name implies. E.g. Down did not have Down syndrome, so it should not be called Down's syndrome, whereas those who refer to ALS as Lou Gehrig's Disease are correct in the term because he had this disease. From my experiences in caring for patients with the condition, some relate stories to me of having been referred to as "having Crohn's," and are quite offended by this. 70.73.141.146 (talk) 23:51, 7 September 2013 (UTC)

I just noticed that this article states "While Crohn's is an immune related disease, it does not appear to be an autoimmune disease (in that the immune system is not being triggered by the body itself)." This contradicts the Autoimmune Disease article, where the Classification table lists Chron's Disease as an accepted autoimmune disease. 13:00 18 November 2013 (CST)

The phrase "surgery is counter-indicated" should read "contraindicated" Rcolgrove (talk) 14:43, 13 March 2014 (UTC)

Semi-protected edit request on 20 June 2014
other will to ==> should be "other will too"

202.19.179.133 (talk) 05:47, 20 June 2014 (UTC)
 * Thanks Doc James  (talk · contribs · email) (if I write on your page reply on mine) 06:03, 20 June 2014 (UTC)

Semi-protected edit request on 9 July 2014
Some typos or awkward wording should be revised, in the third paragraph of the lead section, starting at the fifth sentence. New text: "One in five people with the disease are admitted to hospital each year, and half of those with the disease will require surgery for the disease at some point over a ten year period. While surgery should be used as little as possible, it is necessary to address some abscesses, certain bowel obstructions, and cancers. Checking for bowel cancer via colonoscopy is recommended every few years, starting eight years after the disease has begun." -- 75.161.234.131 (talk) 23:29, 9 July 2014 (UTC)

✅ Thanks for pointing that out - Arjayay (talk) 08:16, 10 July 2014 (UTC)

Global consensus on perianal fistulating disease
10.1136/gutjnl-2013-306709 JFW &#124; T@lk  08:12, 4 August 2014 (UTC)

Research
This "A virally-vectored DNA vaccine against Mycobacterium Avium subspecies Paratuberculosis (MAP) which has been proven to be a cause in many cases of Crohn's Disease. The vaccine has been successful in driving MAP from infected tissues in mice and cattle and it is anticipated that a human trial will begin in mid 2015 pending funding. "

Needs a better ref per WP:MEDRS Doc James  (talk · contribs · email) (if I write on your page reply on mine) 10:06, 16 September 2014 (UTC)

The titles of the three types
Ileal, Ileocolonic and Colonic (adj/adj/adj) are labelled in the first graphic as Ileum, Ileocolonic and Colon (n/adj/n) and two have arrows to a structure, while one does not. I found this a little confusing. Not sure if I should go ahead and try to sort it. — Preceding unsigned comment added by 89.100.128.173 (talk) 20:44, 21 January 2015 (UTC)

Semi-protected edit request on 5 April 2015
I have detailed reaserch on this,which can be a good source to you:- https://www.facebook.com/skdhola/posts/869131336459306

Swetansh001 (talk) 08:44, 5 April 2015 (UTC)
 * Please read WP:MEDRS and feel free to post here. Doc James  (talk · contribs · email) 10:47, 5 April 2015 (UTC)

IBD
This text "Medical Cannabis has been shown to treat Crohn's disease in two clinical studies. Some patients have achieved complete remission. Further study is required to establish which specific cannabinoids help, the optimal dose, and mode of administration, to maximize the beneficial effects." Was added supported by the ref http://www.ncbi.nlm.nih.gov/pubmed/?term=24969296

I do not believe that is a good summary. Ref says "Despite anecdotal reports on medical cannabis in inflammatory bowel disease (IBD), there are few controlled studies." Doc James (talk · contribs · email) 01:52, 13 June 2015 (UTC)
 * Summary has been redone to better represent their findings. Psyden (talk) 02:30, 13 June 2015 (UTC)
 * It sounds (from the abstract) that they are reviewing only studies they have personally conducted. That's still secondary, but it's not independent.  Are there really no better (secondary and independent) sources available, to show that mentioning this preliminary research with contradictory results is WP:DUE?  WhatamIdoing (talk) 03:26, 13 June 2015 (UTC)
 * I am not aware of an independent secondary review. There is not really a conflict in results. The two studies showing improvement involved THC and CBD, the study that did not show improvement only involved low dose of CBD alone. Psyden (talk) 03:36, 13 June 2015 (UTC)
 * Yes it is not a sufficient source to support the text added. Doc James  (talk · contribs · email) 06:22, 13 June 2015 (UTC)
 * concur ( statement not supported)--Ozzie10aaaa (talk) 09:26, 13 June 2015 (UTC)
 * Yes, Doc's summary is much better (if we're to use this source at all). I've reverted to good. Alexbrn (talk) 10:08, 13 June 2015 (UTC)
 * Its the wording I have an issue with, by saying there is "little evidence", it seems to imply that this has been thoroughly studied and little evidence found. There is biological plausibility, much anecdotal claims, and now 2 small clinical trials supporting the notion. The source says much more than the current summary. Psyden (talk) 12:54, 13 June 2015 (UTC)
 * We have had reviewers look around for evidence and little evidence was found yes. Doc James  (talk · contribs · email) 23:58, 13 June 2015 (UTC)

The issue continues. This is cherry picking from the review  Doc James  (talk · contribs · email) 13:34, 13 June 2015 (UTC)
 * This is an entirely different section Doc, and an entirely different discussion, this one is about ongoing research. Feel free to add the negative bits. I have been as close to the original text as possible without plagiarizing. I do not see why you have an issue with this source when it is superior to those already added which simply deal with biological plausibility and preclinical studies. Psyden (talk) 13:43, 13 June 2015 (UTC)
 * It is a low quality review and the bits you have added are WP:UNDUE weight. Doc James  (talk · contribs · email) 13:47, 13 June 2015 (UTC)
 * I agree, one must be objective with articles... the positive parts and negative parts (and not "cherry pick")--Ozzie10aaaa (talk) 18:59, 13 June 2015 (UTC)

External links modified
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Hello fellow Wikipedians,


 * I have just added a link to a website that discuses the Crohn disease on the External links section, it's an old website that helps many people around the world about finding ways to comprehend with the disease and I'll appreciate you reviewing it.

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Semi-protected edit request on 20 September 2015
A recent meta-analysis reporting on vitamin D deficiency in IBD showed that patients with Crohn's disease had a significantly higher odds of vitamin D deficiency compared with controls (Odds ratio = 1.63).

95.234.181.215 (talk) 15:12, 20 September 2015 (UTC)


 * Red question icon with gradient background.svg Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format. I'm not sure exactly where you want that placed in the article. Please reply with more details and reopen the request per the template instructions. Best,  M w w 1 1 3    (talk) 00:01, 25 September 2015 (UTC)

Semi-protected edit request on 6 October 2015
I would like to add this sentence to this article: Carbohydrate restrictive diets, such as the specific carbohydrate diet (SCD) and the low FODMAPs diet have been shown to alleviate the symptoms of some Ulcerative Colitis and Crohn's disease patients (Cope).
 * Cope, G. (2015). Overview of dietary choices for ulcerative colitis and Crohn's disease. Gastrointestinal Nursing, 13(1), 35-41  — Preceding unsigned comment added by Jeberhart93 (talk • contribs) 22:53, 6 October 2015 (UTC)
 * I removed the sprotect. I note that low FODMAP is not just carbohydrate reduced and SCD may not necessarily be carbohydrate reduced, just carbohydrate modified. Please make the edits you see fit and we can discuss here as needed. Samir 05:39, 7 October 2015 (UTC)

Cannabis
I reverted this because of lack of secondary sourcing. Feel free to discuss Samir 00:47, 5 November 2015 (UTC)

External Links Added
Dear Wikipedians Fellow's,

I run a website which helps, gives many useful advise and support regarding the disease. The website helps people to comprehend with the disease and provides beneficial information about it. I added a link to it in the external links section and I'll appreciate you confirming it.


 * Hi. Thanks for this, but please read WP:ELNO, esp. points 10 and 11.  Lugnuts  Dick Laurent is dead 14:07, 11 January 2016 (UTC)

Lancet review
10.1016/S0140-6736(16)31711-1 JFW &#124; T@lk  09:28, 2 December 2016 (UTC)

Isolated colonic Crohn's
May be a distinct disease 10.1136/gutjnl-2016-312673 JFW &#124; T@lk  23:51, 7 January 2017 (UTC)

Hereditary
User:Annapercival,
 * here and
 * here, and
 * here

you added content along the lines of "Crohn's disease can be hereditary, meaning you could inherit genes from your parent(s) to make you more suseptible to getting this disease" following the sentence: Crohn's disease is caused by a combination of environmental, immune and bacterial factors in genetically susceptible individuals."

The lead and the body already discuss genetics and heritability. Is the problem that the word "inherit" is missing? Rather than keep adding content that is redundant and being reverted, would you please clarify here on the talk page what is missing, in your view? Thanks. Jytdog (talk) 21:40, 27 January 2017 (UTC)

External links modified
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External links modified
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Doc James' reversion
I don't fully understand the reason for this revert. Doc James says it "was fine before", but I find nothing like it in the article cited. It seems to me that the article misrepresented its source before I added a direct quote from the article, and after the reversion, once again misrepresents its source. Where do Leiby and Vazirani state "Homeopathy has not been well studied enough in people with Crohn's to determine if it safe or effective". What they actually say is "Although there are no randomized controlled trials to recommend routine use of homeopathic remedies, there is also no evidence that it is harmful." In short, it is in Crohn's disease as it is in all other diseases: homeopathy has not been proven to be effective, and water isn't harmful. We shouldn't be claiming, in Wikipedia's voice, that this is because of lack of study rather than lack of efficacy, and we shouldn't be claiming it in the cited authors' voices either, because they don't say it. - Nunh-huh 05:25, 22 September 2017 (UTC)
 * I've brought in content from the main homeopathy article. This article was out of compliance with the WP:PSCI policy and I have fixed that. Please also see your Talk page. Jytdog (talk) 13:20, 22 September 2017 (UTC)
 * If there are no RCTs it has not been well studied.
 * As long as the text is not overly complicated I am happy. I have simplified it some and split it into two sentence from one overly long one.  Doc James  (talk · contribs · email) 19:37, 22 September 2017 (UTC)
 * The problem, of course, is this: "This is also the situation with regard to Crohn's.[174]" The cited reference doesn't say what this article claims it says: it doesn't say that homeopathic preparations are not effective for treating any condition; it doesn't even say that homeopathic preparations are not effective for treating Crohn's. It should say it; but it doesn't. The cited article only says "there are no randomized controlled trials to recommend routine use of homeopathic remedies". The article is being misrepresented. Intellectual honesty requires that the citation be removed or replaced. - Nunh-huh 20:43, 22 September 2017 (UTC)
 * Intellectual honesty requires that we don't make it seem possible that expensive water might be useful to treat any disease or condition. I fixed the "problem". I am not going to spend much more time on this. Jytdog (talk) 21:29, 22 September 2017 (UTC)
 * Yes, intellectual honesty demands both things. Thanks for the update on your scheduling. Also the sneer quotes, they certainly help us understand how serious you think the problem of misrepresenting sources is. - Nunh-huh 21:34, 22 September 2017 (UTC)