Talk:Cryptogenic organizing pneumonitis

WHAT
WHAT IS THE DEATH RATE WITH BOOP? —Preceding unsigned comment added by 63.246.62.174 (talk) 08:03, 16 October 2007 (UTC)

Answer to: WHAT IS THE DEATH RATE WITH BOOP?
The answer depends on what the cause of BOOP is, and how severe the BOOP is.

The cause could, for example, be amiodarone (ie, amiodarone-induced pulmonary toxicity, AIPT). AIPT can include BOOP, amongst other forms of pulmonary toxicity. In one clinical trial, approx 75% of patients with amiodarone-induced BOOP stabilised or improved after withdrawal of amiodarone, with or without steroid treatment (Chest 1992;102:1005-12). The prognosis of AIPT is generally favourable. Death attributable to amiodarone-induced BOOP occurred in approx 10% of cases reported in the medical literature, although the actual mortality rate in university clinics today probably is clearly lower.

Severe cases of BOOP: Fulminant BOOP is possible after intensive chemotherapy given to some patients with leukaemia (Eur J Haematol 2004;73:67-70) or with other malignant cancers. In clinical experience, fulminant BOOP can often end fatally, although the exact mortality rate is not known. Fortunately, severe cases of BOOP are rare.

Overall, the prognosis of BOOP is generally favourable. This is also true when we look at COP (COP = idiopathic form of BOOP). Fatal cases of COP are rare (King TE. Cryptogenic organizing pneumonia. In: UpToDate [Textbook of Medicine]. Rose, BD (Ed). Waltham, MA, USA. April 2007).

--Dara Koper (talk) 22:23, 13 December 2007 (UTC)