Talk:Cyclic di-GMP

More sources needed
Some of the more specific and tentative facts should have some citation, especially if they've only been shown once. The riboswitch section is one (I think there was a paper in Science), as well as the concept of localization of DGC and PDE enzymes (4th paragraph).Tevye guy (talk) 08:48, 30 July 2010 (UTC)


 * I added a citation for the localization of enzymes statement. The riboswitch citations occur in the cyclic di-GMP-I riboswitch and cyclic di-GMP-II riboswitch articles, so I didn't redundantly put them in.  I can add others; other than the riboswitches, most statements are from the Tamayo paper. Zashaw (talk) 02:28, 22 January 2011 (UTC)

PilZ Domains
Also, regarding this passage (5th paragraph):

"The PilZ domain has been shown to bind cyclic di-GMP and is believed to be involved in cyclic di-GMP-dependent regulation, but the mechanism by which it does this is unknown."

How uncertain is this anymore? I thought it was pretty well established that PilZ domain proteins bind to cyclic di-GMP and cause conformational changes that turn effector proteins on/off.Tevye guy (talk) 08:48, 30 July 2010 (UTC)

Plenty of New Info to Add
The last few years have seen quite a bit of solidifying of information about more aspects of cyclic di-GMP signaling. It would be great to see this reflected on Wikipedia. Recently papers have come out demonstrating asymmetrical segregation of cyclic di-GMP into daughter cells in caulobacter (allowing the 'stalk' to form), and PilZ domains have become more established in the literature. If anyone else is interested in this, this is an article that could use some love! —Preceding unsigned comment added by 67.40.25.250 (talk) 09:15, 30 July 2010 (UTC)