Talk:Cyclooxygenase-2 inhibitor

External links modified
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I have just modified 1 one external link on COX-2 inhibitor. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit User:Cyberpower678/FaQs for additional information. I made the following changes:
 * Added archive http://web.archive.org/web/20080509195022/http://www.cancer.gov/cancertopics/factsheet/APCtrialCOX2QandA to http://www.cancer.gov/cancertopics/factsheet/APCtrialCOX2QandA

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Cheers.—cyberbot II  Talk to my owner :Online 13:38, 9 June 2016 (UTC)

Needs better balance
This article passes over much of the information about COX-2 inhibitors quickly, then spends the bulk of its wordage on *potential* uses + controversy/fraud/etc and I find this odd. It ought to look more like the wikipedia entry for NSAID with a more thorough introductory description, examples, uses, mechanism of action, adverse effects, contraindications. I don't have the time or energy to do this hence I'm just adding my 2 cents to the talk page.Niccast (talk) 23:31, 19 March 2020 (UTC)

Apoptosis
The last two paragraphs reference apoptosis, a well known biological function of programmed cell death. But the wording is a little too dramatic, in my opinion:

"Coxibs such as Celebrex (celecoxib), by selectively inhibiting the overexpressed COX-2, allow p53 to work properly. Functional p53 allows DNA damaged neuroblastoma cells to commit suicide through apoptosis, halting tumor growth."

Also, this really ought to link to apoptosis, rather than suicide. ThreeRocks (talk) 03:05, 30 September 2022 (UTC)