Talk:Cyclooxygenase-2 inhibitor/Archive 1

article creation
Firstly, I know this reads like a plagiary of an article, but it's a review I wrote not copyright anywhere, so that's not a problem.. Secondly, it is totally unwikipediafied and in need of same. I'll get around to it sometime, but anyone who wants to chip in in the meantime is welcome. User:Gzuckier, unsigned on 2 July 2004.


 * It is still far from perfect, and it still original research poorly adapted to Wikipedia. Thankfully Berek has linked some terms, but I would warmly encourage you to follow some very basic Wikipedia style conventions. JFW | T@lk  19:30, 31 Aug 2004 (UTC)

I do mostly, but I just had this and I thought maybe people could get some use out of it but didn't have the time to rework it myself. (Still don't; maybe later). Meanwhile, people are doing a good job whacking at it. Wiki works! Gzuckier 14:00, 2 Sep 2004 (UTC)

I deleted some information about the law firm handling the Vioxx litigation. It sounded like an advertisement to me. The last thing we want to see in Wiki is an advertisement for class action lawsuits. I didn't delete the entire entry. If others think that the law firm's name should be deleted, I say go for it. Maybe a discussion of the litigation or a link to a page about the litigation would be more appropriate. -Andrew

Deleted from External links, added to external links on March 1, 2007
This marvalous report clarify a lot of concern regarding NSAIDs & COX-II inhibitors. The question remain open what is risk /benefit ratio of using NSAIDs or COX-II. Patient on short term treatment as in acute painful conditions, has lower risk of developing AEs but the problem is in patient with long term as OA or RA?

NSAIDs +PPI or/ H2A may be a safe alternative to have efficacy witout GIT side effect But the question is still open is it Prostaglandin issues- what about Asprin which is now routinely with all patients with CV risk of thrombosis despite it block both COX 1 & 2

Is the solution to combined Coxib with Aspirin? -- random editor?

Under risks and adverse effects
"This cardiovascular risk of COX-2 specific inhibitors is not surprising since prostaglandins are involved in regulation of blood pressure by the kidneys" - this isn't correct. IIRC, the risk of cox-2 selective inhibitors is independant to blood pressure effects. Also, I wasn't aware NSAIDs caused blood pressure effects, unless you mean through ARF or something of the like. 128.250.5.246 (talk) 11:01, 14 June 2009 (UTC)

I find this line very worrying, too. The COX article in wikipedia cites a paper in the BMJ, a metastudy, which suggests that it's not COX-2 specificity that causes atherothrombosis, but that other NSAIDs such as diclofenac and ibuprofen (which are more or less COX2 specific) are equally likely to increase the incidence of it. The exceptions are aspirin and naproxen. (I read another paper, I don't have the reference to hand, but can dig it out) which suggests that the aspirin and naproxen exceptions are due to the counterweight of their antiplatlet effects being protective. So at the very worst, this sentence is highly controversial and should be qualified. I don't have the literature to hand, and haven't done a full search to appropriately weight these papers: someone more in-the-literature should probably change this. I'm not going to change it without that kind of backing with all the US ambulance chasers lurking around this issue 131.111.21.21 (talk) 10:58, 4 August 2009 (UTC)

Relevent Information from a nonwiki library person
The journal "Cell" today (11/22/2013) published an article covering a new use for COX-2, reported on the publisher's website.

http://www.elsevier.com/connect/preventing-marijuana-induced-memory-problems-with-OTC-painkillers — Preceding unsigned comment added by 131.193.153.134 (talk) 00:19, 23 November 2013 (UTC)
 * Thanks, but we do not put this kind of information into Wikipedia.Jytdog (talk) 02:51, 23 November 2013 (UTC)