Talk:Cytokine release syndrome

Comment
Is this the same as, or a weak form of, cytokine storm? Also, "the antibodies bind to the T cell receptor, activating the T cells before they are destroyed." What does "they" refer to, the antibodies, the T cells or the receptors? AxelBoldt 05:23, 15 August 2006 (UTC)


 * The whole entry is unsourced. It is unclear in what sense it is different from cytokine storm. The present term (CRS) covers exactly the pathogenesis of the former. It seems CRS gained currency as part of the anti-CD28 disaster. JFW | T@lk  11:40, 18 August 2006 (UTC)

See. JFW | T@lk  07:10, 7 September 2006 (UTC)

I agree. Surely this article should be merged into "cytokine storm"? Marchino61 (talk) 07:19, 17 October 2014 (UTC)
 * I did it the other way. This is actually the more general concept, "storm" being severe CRS. Jytdog (talk) 21:33, 4 February 2018 (UTC)

Deaths?
Removed the reference to deaths for the 2006 TGN 1412 phase I trials. None of the subjects died. 2601:240:8101:3140:C1ED:AD20:69B0:E1AD (talk) 06:52, 22 October 2017 (UTC)
 * thanks for fixing that. Jytdog (talk) 15:35, 22 October 2017 (UTC)

Disastrous
i don't often use adjectives when i write WP content, but the trial of TGN 1412 was a disaster and has been widely referred to that way. we can go with no adjective. But if we use one it needs to be something negative. The trial was unambiguously a negative event. Jytdog (talk) 15:13, 23 October 2017 (UTC)

new coronavirus
WUHAN VIRUS/Experts find how moderate 2019-nCoV infection ends with death possible cause for some of the deaths of otherwise healthier individuals in current outbreak of 2019 novel coronavirus.Mercurywoodrose2600:1700:5FA1:61B0:B917:BBF8:5992:6B9 (talk) 19:09, 9 February 2020 (UTC)

Research
The Research section is currently very thin and the only entry is medically-speaking problematic. The Research entry is currently an inferential plug for probiotics. The section mentions that probiotics can modulate certain cytokines, and since those same cytokines have been implicated in CRS, it tries to create the impression that there is an established connection between CRS and probiotics / nutritional supplements. Minimally, the research section should be flagged as "references do not directly relate to CRS". What do you think?


 * I have removed it for now: you made a good point that this might be a wrong impression readers might get. I was hoping somebody would improve the text or move it elsewhere if needed. I think it would be more appropriate at the inflammatory cytokine article. For it to be readded here I think it needs a good source on a potential connection between CRS in specific and probiotics. This connection doesn't have to be established because it's a section on the ongoing research but it has to be established that there might be a connection. And at a minimum it needs to be clarified better. I haven't moved it to inflammatory cytokine – maybe somebody else can do that.
 * --Prototyperspective (talk) 19:43, 5 April 2020 (UTC)

Cytokine storm syndrome
I've found articles which describe differences between cytokine release syndrome and cytokine storm syndrome/cytokine storm: (CRS: a clinical overview),  (Table 1. Cytokine storm syndromes). Cytokine release syndrome is a special case of cytokine storm syndrome. Moreover cytokine release syndrome and cytokine storm have different characteristics and main mediators. -- D6194c-1cc (talk) 15:34, 5 May 2020 (UTC)

Medicine vs drug
Doc James, why did you changed drugs to medications? I do no understand. Drugs can have negative adverse effects while medications are benign. CRS is caused by drugs not medications as I understand. By the way, please check my edits, I have no experience in medicine and my English might be not so good. -- D6194c-1cc (talk) 19:31, 9 May 2020 (UTC)

Storm vs. release syndrome
I don't know enough to do it myself, but, modulo the above discussions, somebody better explain the difference because right now it looks ridiculous. Serious, worried people will come here to understand whats happening to their husbands, wives, and kids; and right at the top, we say "Not to be confused with Cytokine storm." Then TWO SENTENCES LATER we say "It refers to cytokine storm syndromes..."

My reaction when I read that was fear: "OMG, these so-called 'scientists' don't know what the eff they're talking about. They don't understand it at all!" Verdana ♥ '''Bold 03:58, 17 May 2020 (UTC)


 * If this is different the definitions need to be clear in both articles. The two articles are still has mixed info and I am confused. Whoever split this needs to get it straightened out--Cs california (talk) 07:59, 25 May 2020 (UTC)
 * As I understand cytokine release syndrome is used in context of drugs adverse effects while cytokine storm is used in context of diseases. Here is some info: . Also some journal articles differentiate those terms by several criteria. Cytokine storm syndrome is any syndrome that can be presented with cytokine storm as I understand. And cytokine storm is medical condition. -- D6194c-1cc (talk) 21:41, 25 July 2020 (UTC)