Talk:DNA clamp

Untitled
Article merged: See old talk-page here

Merger proposal

 * Support – DNA clamp is already a well established article that covers essentially the same material as in the beta clamp article. The main difference is that the material in the later is restricted to the prokaryotic polymerase III enzyme were as the former also covers the corresponding eukaryotic enzyme. Boghog (talk) 09:47, 31 January 2010 (UTC)
 * Support – Better for our readers to have it all in one article. Adrian J. Hunter(talk•contribs) 03:56, 4 February 2010 (UTC)
 * Done - Just merged. Sjodenenator (talk) 03:14, 25 February 2010 (UTC)

Antibiotic Target?
Since the DNA clamp used by bacteria - the beta clamp - is so different from that found in eukaryotes (like humans), does it not follow that drugs could be made which specifically interfere with the functionality of the bacterial beta clamp that would not have any effect on DNA clamps in human cells? A drug that could drastically disrupt the speed with which bacteria can copy their DNA, and therefore the speed with which they can multiply, could have powerful antibiotic activity.

Has this been investigated at all? Spiral5800 (talk) 01:30, 29 December 2010 (UTC)

Topological equivalence of bacterial clamps
The three domains in a bacterial clamp are currently declared (without reference) to be 'topologically non-equivalent'. This is not true, and probably comes from incorrectly merging adjacent beta strands in secondary structure assignment (see the topology diagram at pdbsum, for instance). Inspecting the structure makes it clear that the topology is equivalent. --Quantum7 10:50, 4 July 2014 (UTC)

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DNA clamp
Voice concern 149.54.27.214 (talk) 15:29, 22 November 2022 (UTC)