Talk:DPT vaccine/Archive 1

Diptheria
The role of the membrane and obstruction, along witht eh toxin it produces needs bringing out - I don't know it well enough at present to actually do that though. Midgley 14:06, 8 March 2006 (UTC)
 * The expert needed tag on DIptheria has now been removed twice with no comment on the talk page, once by an IP address not logged in and with no history of edits 71.139.72.3, once by Ombudsman, each time with a summary that is less than a complete description of the changes. If there is some reason to think that the Diptheria section is so good it doesn't need expert attention, then posting it here would be reasonable.  Midgley 21:13, 13 March 2006 (UTC)


 * Why is that section even here? We already have articles for diphtheria, pertussis, tetanus, and Vaccination schedule. --Arcadian 22:23, 13 March 2006 (UTC)


 * I agree. Merging would be a good idea.  On a general note (and perhaps we need a Wikipedia: page on policy about handling vaccine articles) there is a tendency to present particualr mixtures of vaccines as being something separate from the vaccines.  I think it causes more confusion than it saves and we should tackle vaccines - IE disease entities - separately, or even just as a composite article on how individual vaccines work, section for each - under a general explanation how vaccines work. Alternatively, each disease might have its vaccine section, we don't have a full article for "treatment of pneumonia with antibiotics" we have one on (I suppose) Penumonia, whcih inlcudes something on treatment as a section. Midgley 12:18, 14 March 2006 (UTC)


 * For now I've just deleted the content that wasn't related to the DPT vaccine. There didn't appear to be any new information there that needed to be merged into the disease articles (but let me know if I missed something.) --Arcadian 16:15, 14 March 2006 (UTC)

Ascertaining Contents and Media of Vaccines
I have been searching for some hours in my amateur way for the contents (active/inactive ingredients) and medium of any tetanus booster shot available in the United States, and suggested by medical professionals as necessary in order to avoid catastrophic illness. I was eventually able to find the ingredients of a children's vaccine, but not the means of delivery or ingredients in the available adult boosters. Any thoughts on why this is impossible to find on Wiki or Google? Mel0209 (talk) 15:45, 2 August 2008 (UTC)


 * I don't understand the bit about the inactive ingredients and medium being necessary to avoid illness, and I suspect that you're in over your sneakertops here, but I can tell you how to find the information:  The (only) brand name for adults in the US is "Adacel".  Search for Adacel prescribing information.  All ingredients for any biologic are normally listed in the first section (after any boxed warnings, except that there aren't any for this product), under a heading that will say "Description" (or something very similar).
 * If memory serves, the medium is sterile water. WhatamIdoing (talk) 21:18, 3 August 2008 (UTC)

The inactive ingredients include things like the liquid the vaccine is contained in, buffers and saline used to make it kinder on the tissues it is injected into, and preservatives to reduce the risk of bacterial or fungal contamination. You can get the full prescribing information on it from the NIH/NLM Daily Med web site dailymed.nlm.nih.gov--69.137.225.247 (talk) 02:16, 12 April 2011 (UTC)

when
when the right time our baby should get DPaT vaccine? is that the condition of baby when get the vaccine will be a consideration?


 * According to the NIH, "DTaP immunization is usually a series of injections given to children at ages 2 months, 4 months, 6 months, 15-18 months, and 4-6 years." Also read the "DELAY OR DO NOT GIVE" section of the link for more details on your second question. --Arcadian 05:34, 20 December 2005 (UTC).......

The above hasn't changed much, but please see current immunization schedules from ACIP. Adults need a dTap. I will try and add links when I have more than 30 seconds... —Preceding unsigned comment added by 69.137.225.247 (talk) 03:05, 12 April 2011 (UTC)

Different Variations of DPT (TDap, DTap, Tdap, etc)
If someone could clear up the way this article explains the variations of vaccine types for Diphtheria, Tetanus, and Pertussis, that would be helpful. Currently, the introductory paragraph indicates the difference between DTP and DTaP, which is that the latter is acellular while the former is a whole-cell concoction. However, the description of DTaP conflates the variations of this vaccine:

"DTaP (also known as Tdap,DTPa, and TDaP) refers to similar combination vaccines in which the pertussis component is acellular."

The line equates DTaP with Tdap, or at least ignores the difference between them. Although this is explained later in the article, it is confusing in that Tdap is slightly different while DTPA and TDaP do seem to be equivalent with DTaP. I would suggest something like what follows, but I'm no expert and don't feel qualified to change this paragraph myself. If someone more qualified could look this over and change the paragraph as needed, that would be great.

"A group of similar vaccines, including DTaP and Tdap, incorporate acellular pertussis components in the form of antigens as opposed to the killed whole cells in DTP. DTaP is sometimes referred to as TDaP and DTPa, but should not be confused with Tdap." — Preceding unsigned comment added by Fussbalspieler7 (talk • contribs) 19:30, 6 June 2011 (UTC)

Why a triple-vaccine?
Why is there a single vaccine for these three? Is the active agent the same for vaccinating against all of these diseases, or does it just make sense to combine them because they're all necessary vaccinations that have the same timeframes? I think the article should make this clear. ~ Booya Bazooka 22:46, 20 March 2008 (UTC)


 * They are different agents. They are combined basically for convenience:  one trip to the clinic and one jab instead of three trips and three jabs.  There is no advantage to doing them separately.  The human body deals with thousands of different pathogens every single day, so adding (parts of) three more to the mix is not a significant strain on the system.  WhatamIdoing (talk) 17:14, 15 July 2008 (UTC)

more over to the reason mentioned above it has also been suggested using these three antigenic components together increases immunity response and therefore provides a longer protection time.Minro69 (talk) 17:18, 1 January 2011 (UTC)minro69

I did a rough count of the number of vaccine-doses recommended in the US and EU by age 6, it is over 50, most before the age 2. A version of DPT is normally called for 4 times by age 6 which is 12 vaccine-doses. Ongoing work on 5 or more vaccines in one injection as standard are underway to reduce it to one jab per early child welness visit. At age 2 and 4 months, the recommendation is 5-6 jabs each visit without multiple vaccine even with DTaP, thus DTaP-Hib-IPV, MMR-Varicella, DTaP-Hib, HepB-Hib,... This is an interesting topic that deserves an article, but I'm not connected enough to the field to know what it would be called. "Public health vaccination schedules"?? Mulp (talk) 01:05, 26 May 2012 (UTC)

Removing section on "Combination vaccines with whole cell pertussis"
I am removing the entire section entitled "Combination vaccines with whole cell pertussis." The first paragraph consists of a faulty interpretation of an NPR story from 2009, long after the US had switched to acellular pertussis vaccines. The second and third paragraphs contain no citations.Jane Snow (talk) 05:51, 11 June 2012 (UTC)


 * Rather than removing all of this content, I wonder if it can be improved? I'm restoring the first couple sentences in the section removed.  Correct me if I'm wrong, but those two sentences don't look problematic in their sourcing. --Xaliqen (talk) 20:12, 11 June 2012 (UTC)


 * No, the restored sentence is incorrect. As I have stated above, pertussis has never been eradicated in the United States, and the article in question does not state that it was. Discussions about recent US trends in vaccine refusal may merit inclusion in this article, but do not belong under a heading about whole cell pertussis, as this vaccine has not been in use in the United States for some time. I would recommend that this topic be given a heading of it's own.76.175.171.91 (talk) 01:00, 12 June 2012 (UTC)


 * I agree, the remaining content of the "Combination vaccines with whole cell pertussis" section doesn't appear to have any relevance to the section heading. If it does get moved to its own (properly labelled) section, a summary of past whole cell pertussis vaccines to contrast the existing summary of acellular pertussis vaccines should go in the "Combination vaccines with whole cell pertussis" section. 207.67.29.250 (talk) 18:36, 20 July 2012 (UTC)

How Long is it Good For?
It would be good to know, especially now with a whooping cough on the rise, how long these shots are good for. NStahl (talk) 15:36, 25 June 2010 (UTC) what text books say is that after childhood injection the modified version of the vaccine(DT) should be repeated at age 14 but since immune system if each person's body is different there's not a point that works for eveyone,after this injection at age 14 it's recommanded to be repeated every ten yearsMinro69 (talk) 17:16, 1 January 2011 (UTC)minro69 einstien was a nice actor and cricketer — Preceding unsigned comment added by 180.215.204.104 (talk) 09:49, 11 March 2014 (UTC)

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DTP and Doubled Mortality Rate
As in the history of the Rotovirus vaccine, this article is severely biased toward the "all vaccines must be good vaccines" perspective since it does not mention or address the discontinued inclusion of the whole cell DTP in the CDC schedule due to high injury/reaction rates. The DTaP was introduced to the schedule in 1998 with significantly fewer injury/reactions. The cases of injury adjudicated by the National Vaccination Injury Compensation program for the DTP was 40 times higher than for the DTaP. — Preceding unsigned comment added by 199.64.6.150 (talk) 17:40, 9 September 2016 (UTC)

An interesting study and article on DTP doubling the mortality rate in children after one dose. articles.mercola.com/sites/articles/archive/2011/03/24/disturbing-data-about-vaccinated-children.aspx Could be incorporated into the article, but I would want to see the actual research. Something like this definitely needs a strong reference to cite, and I would say that would have to be the actual research, I don't think CNN or this website is strong enough in this particular case. — al-Shimoni  (talk) 01:45, 25 March 2011 (UTC)
 * Mercola is well known for his fringe ideas about vaccines. He is not a reliable source.  And there is NO evidence to support his delusions.   Orange Marlin  Talk• Contributions 05:59, 25 March 2011 (UTC)
 * Many thanks. Although I had not heard of him, claims that could potentially "overturn the boat" (not just "rock" it) I tend to think need a higher bar of proof than CNN, or whoever Mercola is, before incorporating into an article like this. Unless something substantial surfaces, I would say we can ignore it, then. — al-Shimoni  (talk) 09:45, 26 March 2011 (UTC) (Original version dated 09:41, 26 March 2011 (UTC))

if he walks like a duck
OK, I surfed over the Mercola site, and was struck by its effort to try and appear to not be a sensationalist anti-medicine conspiracy theorist site.

There are several studies from Guinea-Bissau looking at multiple immunizations, use of micronutrient (vitamin A in most cases) supplements in conjunction with live measles vaccine. Since I didn't feel like giving them my email address, and there is no other way to visit the site, it was hard to judge. The fact that they cite Age of Autism as their source makes it hard to track down the original reports. There are some reports in medline that suggest that mortality from complications of the measles vaccine may be increased in malnourished infant girls who are hospitalized. Not exactly what support his assertion that giving the immunization to a child living in a developed country, who was properly nourished or who didn't suffer complications from measles vaccines would be harmful. Sort of a stretch. Like oleic acid on water thin. It would take a week to review the literature, over 32 papers, all citing multiple other studies. All in small, biased populations, none of which represent conditions in Europe, Japan, South Korea, Australia, or even most of the US (we do have our own problems with malnutrition in poor African American children, but not nearly on the same scale), and some cities, like D.C. do have 3rd world infant mortality figures, but there is a wide gulf between rural/inner city poor in the US (as bad as that is) and rural poor in Africa.--69.137.225.247 (talk) 02:30, 12 April 2011 (UTC)
 * Wow, so Mercola is not only anti-vaccine but he's jumped on the pseudoscientific vitamin crowd. Oh well.   Orange Marlin  Talk• Contributions 02:33, 12 April 2011 (UTC)

Not at all. Well, he (Mercola) may be, but don't let my statement lead you to believe that. Also, Vitamin A is a very important nutritional supplement in developing countries, particularly in those at greatest risk of death from measles (vitamin A is the standard therapy for measles in developing countries, and two doses of 100,000-200,000 IU on separate days is associated with a 30% risk reduction. See Pediatrics. 1993;91(5):1014 and other sources for the studies this is based on.) You have to have pretty severe baseline (1% mortality or greater) and basically undetectable vitamin A levels in your food (which is far too much of rural Africa and Guinea-Bissau GDP is something like $500. They are on the bottom ten countries in the world from an economic POV, have lost many of their physicians recently, have 5 physicians per 100K population, etc.)--69.137.225.247 (talk) 02:56, 12 April 2011 (UTC)
 * Mercola is an evil little fuck. I agree with you on Vitamin A, but I'm not going to go overboard and consider it a replacement for MMR vaccines.  Unless I'm misunderstanding you.  Nevertheless, if Mercola said the sky was blue, I'd have to reverse my knowledge of the atmosphere.   Orange Marlin  Talk• Contributions 03:27, 12 April 2011 (UTC)

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Confusing Section
The section "Purported non-specific effects" is very confusing. I have a science background and I have no idea what they are talking about. I suggest so editing for clarity. — Preceding unsigned comment added by 96.40.123.249 (talk) 01:34, 2 April 2017 (UTC)

Merger proposal
Then, wrap the text within with: I propose that DTPa be merged into DPT vaccine. I think that the content in the DTPa article can easily be explained in the context of DPT vaccine, and the DPT vaccine article is of a reasonable size that the merging of DTPa will not cause any problems as far as article size or undue weight is concerned. T0mpr1c3 (talk) 04:52, 28 June 2018 (UTC)
 * The material in the DTPa article was essentially the same as some of this article, I have clarified that it can also be spelled DTPa and dTpa in this article. Other than the alternate spelling the stuff about giving adults a lower dose of d and p was in both articles already, so I have CSD'd DTPa, since it was really just an article about an alternate spelling. Tornado chaser (talk) 20:19, 31 July 2018 (UTC)
 * Looks legit. I'm not a subject matter expert, but I think the merge is satisfied given the terms are different nomenclature and strengths (ordering and capitalization). Better than the IP just deleting as a redirect and removing the tag without comment. JesseRafe (talk) 20:28, 31 July 2018 (UTC)


 * This makes obvious sense. DPT, DTPa, Tdap and DTaP are all targeting the same diseases and all subject to the same antivax bullshit, so it makes good sense to have just one article unless and until some specifics drive separation. Guy (Help!) 20:49, 31 July 2018 (UTC)
 * I actually decided to redirect DTPa→DPT, rather than CSD. Tornado chaser (talk) 21:09, 31 July 2018 (UTC)
 * Thanks. I have taken the liberty of removing the merge proposal tag. T0mpr1c3 (talk) 17:45, 1 August 2018 (UTC)

Redirects
Added numerous redirects per CDC guidance, including: ― Bio chemistry 🙴 ❤   15:27, 16 July 2020 (UTC)
 * Adifteper
 * Alditerpera
 * Anatoxal Di Te Per
 * D.T. Coq
 * Deptacel
 * Dif per tet all
 * Funed-CEME
 * Imovax D.P.T.
 * P.D.T. Vax
 * Serap (added entry to disambiguation page)
 * Sii Triple Antigen
 * Trenin DPT Behring
 * Triacel
 * Triacelluvax
 * Tri-Immunol
 * Tripacel
 * Tripla
 * Triple (added entry to disambiguation page)
 * Triplice (VT)
 * Tripvac
 * Tritanrix
 * Trivacuna Leti
 * Trivax
 * Trivax-AD
 * Trivb
 * V T (Vacine Triplice)
 * Vac-DPT
 * Vacina Triplice
 * Tripavac
 * Vaksin Serap
 * Welltrivax Trivalente
 * Zatribavax

Foundations II 2020 Group [16] proposed edits
Our goals include:


 * Finding references and published articles to add citations
 * Providing a possible side effect profile for the vaccine
 * Adding a section on the indications or elaborating more on why patients require the vaccine
 * Confirming the citations listed are valid/relevant/strong
 * Update in pregnancy guidelines/section (clean up)
 * Researching related vaccine and providing guidelines on the use of them
 * Adding a vaccination schedule to the listed vaccines

--KTruong1337 (talk) 20:27, 28 July 2020 (UTC)
 * Hi (and the rest of Group 16), welcome! Those sound like excellent goals.  and I will keep an eye on this talk page, so if you have any questions as you get to editing, feel free to ask here. As an additional goal, you'll see that a small amount of info on DPT vaccines is at DTP vaccine. It would be great if we could merge everything on the topic here to this page. If you (Group 16 folks) have time to look that page over and see if there's anything worth merging into this page, that would be much appreciated. It's great to see editors taking an interest in the infectious disease related pages! Lord knows we could use all the hands/eyes we can get. Happy editing. Ajpolino (talk) 21:12, 29 July 2020 (UTC)

Foundations II Peer Review 2020 by Group 15
Part 1:

1) Do the group’s edits substantially improve the article as described in the Wikipedia peer review “Guiding framework”?

Yes, the group added information about side effects of the vaccination as well as special considerations in pregnancy. They also enriched the overall history of the vaccine, as well as covered the use of other related vaccines (i.e. Td booster). There is frequent use of citations. --J La, UCSF PharmD Candidate (talk) 21:42, 3 August 2020 (UTC) C.Nowak, PharmD (talk) 21:42, 3 August 2020 (UTC) Ernielum (talk) 21:43, 3 August 2020 (UTC) SLin101 (talk) 21:44, 3 August 2020 (UTC)

2) Has the group achieved its overall goals for improvement?

Yes, the group’s goals included adding information on side effects, a section on pregnancy, and more citations. The group could potentially add more information to the history section, explaining how the development of the vaccine came to be based on disease outbreaks, and the effectiveness of the vaccine. There was a comment on the talk page suggesting the merge of this article with the article “DTP vaccine.” Since the group’s article “DPT vaccine” has more relevant and thorough information, we would also suggest adding the information from the “DTP vaccine” to the “DPT vaccine” article and merging them so that “DTP vaccine” would be redirected to “DPT vaccine.” --J La, UCSF PharmD Candidate (talk) 21:42, 3 August 2020 (UTC) C.Nowak, PharmD (talk) 21:42, 3 August 2020 (UTC) Ernielum (talk) 21:43, 3 August 2020 (UTC)SLin101 (talk) 21:44, 3 August 2020 (UTC)

Part 2:

1.) Does the draft submission reflect a neutral point of view?

The majority of the wiki page reflects a neutral point of view. The only section that might want to be changed is the history section. History Section: "During the 21st century, many parents declined to vaccinate their children against pertussis for fear of perceived side effects despite scientific evidence showing vaccines to be highly effective and safe." The can be viewed as not neutral, especially the word perceived. Overall great job at making the article neutral and informative! SLin101 (talk) 21:36, 3 August 2020 (UTC)

2.) Are the points included verifiable with cited secondary sources that are freely available? If not, specify…

Yes, each of the points that are made have cited secondary sources. The links in the “references” section work and are accessible, and are representative of the information presented in the article. For example, in the history section, the sources include a journal article from Human Vaccines & Immunotherapeutics and an article from Immunization Action Coalition. However, citation 8, the NPR article titled “Is Vaccine Refusal Worth The Risk?” is more of a news article with expert and patient testimonies, so one suggestion would be to find a secondary source that has more cited references. There is also a missing citation in the “Combination vaccines with acellular pertussis” section, at the end of the second paragraph in the “Tdap” sub-section. --J La, UCSF PharmD Candidate (talk) 21:33, 3 August 2020 (UTC)

3.) Are the edits formatted consistent with Wikipedia’s manual of style? If not, specify…

Yes. Group made good use of headings and sub-headings to differentiate topics (such as Side Effects), wrote strictly in the 3rd person perspective and did not use medically inclusive language (such as patients). There was some use of medical jargon (specifically antigens), however, that we recommended to link-out to the corresponding wiki article in order to help the viewer follow along. We also recommended to add some photos to add an additional layer of depth to the article. C.Nowak, PharmD (talk) 21:42, 3 August 2020 (UTC)

4.) Is there any evidence of plagiarism or copyright violation? If yes, specify…

There is no evidence of plagiarism or violation. Edits are properly cited and written from scratch. Ernielum (talk) 21:32, 3 August 2020 (UTC)

Additional: Words that we recommend linking out
 * Antigen
 * Acellular
 * Related vaccines section Dt and Td are bolded but not linked

DTaP section Suggest adding pictures (for example, of the vaccine) C.Nowak, PharmD (talk) 21:43, 3 August 2020 (UTC)
 * "Recent research suggests that the DTP vaccine is more effective than DTaP in conferring immunity, because DTaP" When is recent?SLin101 (talk) 21:29, 3 August 2020 (UTC)

Merge Proposal
I propose merging DTP vaccine into DPT vaccine. Both pages are talking about the same thing: vaccines that immunize against diphtheria, pertussis, and tetanus. The order of the abbreviation is irrelevant. This would also be helpful for the DPT vaccine page, as the DTP vaccine page refers to vaccine products that are used outside North America—something that is lacking from the current DPT vaccine page.― Bio chemistry 🙴 ❤   15:54, 16 July 2020 (UTC)
 * Support and happy to help with the merge if you need another set of hands. I didn't realize we had two separate pages. Ajpolino (talk) 15:58, 16 July 2020 (UTC)
 * Thank you for your input. Pending the outcome of this proposal, I would happily welcome your assistance with the merge.― Bio chemistry 🙴 ❤   16:01, 16 July 2020 (UTC)


 * Support makes sense to me -- Guerillero &#124;  Parlez Moi  21:23, 17 July 2020 (UTC)


 * I support this merger --Sstrome (talk) 16:37, 4 August 2020 (UTC)
 * I also support Chalky 23:21, 19 September 2020 (UTC)

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 June 2020 and 21 August 2020. Further details are available on the course page. Student editor(s): Sstrome, M.song, Future UCSF Pharm.D, KTruong1337, Onom12. Peer reviewers: Ernielum.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 18:58, 16 January 2022 (UTC)

Feedback on DPT vaccine in pregnancy
To make the language of this section more inclusive, consider changing pregnant women to pregnant people.

Consider expanding upon how effective"cocooning" is versus vaccination during pregnancy with regards to infectivity rates. Superstarbear97 (talk) 18:55, 12 September 2022 (UTC)

Tdap
I think side effects on pregnant people was an important section that was missing in this article, I also like how reference were included. Maybe just adding hyperlinks on definitions on preterm birth and eclampsia, so the general public can refer to them when reading. Alasmakl (talk) 19:02, 12 September 2022 (UTC)