Talk:Diclofenac/Archive 1

= Topics from 2005-2009 =

Some side-effects
Can someone add something about that latest Danish study (embargoed until Sep 2010) that showed a significantly increased risk of stroke after diclofenac administration? I'm sure google scholar has the citation.....

Question: Is there some connection between taking Diclofenac and menstrual bleeds in post menopausal women taking non-bleed HRT? I would be very interested to get some feed back. Catherine - 62.6.139.10 11:41, 17 August 2005


 * I don't see an association to HRT, as non-bleed HRT is said to normally increase coagulation tendencies. But Diclofenac may infrequently cause gynecological bleedings, either due to thrombocytopenia or due to direct inhibition of thrombocytic aggregation, alone or with other anticoagulants (low dose Aspirin, Heparine, coumarines). Do you take one of those? Perhaps, you should ask for laboratory examinations, if the bleeds occur again or if you have other symptoms (skin bleeding, unusual fatigue etc.). Diclofenac can have a great number of serious side-effects during longterm treatment, so you should consider to terminate Diclofenac if possible. For pain often Acetaminophen is a good alternative. Your doctor will know. I would be interested to hear from you again what happened.


 * Best of luck. Klaus - 84.44.226.90 16:59, 18 October 2005

Effects on vultures
I find the comment about the decline in the vulture population hilarious. I find difficult to believe that so many vultures would die for this reason. But I really do not know. --Anagnorisis 18:38, 28 October 2005 (UTC)


 * Well, I would not have included it if this paper had not been in Nature and cited by Bandolier. JFW | T@lk  01:20, 30 October 2005 (UTC)


 * A little research would have told you it's anything but hilarious. Indeed, it was well reported in the media at the time, too. James 15:52, 12 November 2006 (UTC)

Ibuprofen and other NSAIDs are also used to treat animals, & are also toxic to vultures which eat the deceased critter later. — Preceding unsigned comment added by 2602:306:CF99:2080:C1F0:55A4:804D:2FCA (talk) 19:39, 6 April 2018 (UTC)

diclofenac salts
What are the difference between the diclofenac sodium and diclofenac potassium?
 * —Preceding unsigned comment added by 82.114.160.33 (talk • contribs) 20:13, 6 August 2006

Good question - I think it affects uptake rate - Diclofenac sodium is sparingly soluble in water while diclofenac potassium is very soluble in water. There does not seem to be a significant difference in pain relief between the two salts. Perhaps there are also implications for the Na/K balance in the body? James 15:39, 21 November 2006 (UTC)

Cardiovascular side-effects
Recent news item for consideration: http://www.nature.com/news/2006/060911/full/060911-6.html (Nature News, 13 September 2006). --User:Ceyockey ( talk to me ) 13:57, 16 September 2006 (UTC)

Asthma related side effects? 124.168.196.118 (talk) 09:41, 14 July 2008 (UTC)

Gel
Here in Australia it seems to me that the only commonly-available orally-administered painkillers are paracetamol, aspirin and ibuprofen. I've only come across this Diclofenac stuff in topically-applied gel form. What difference does this make medically? Are there the same liver and kidney risks? Can I rub on Diclofenac and also take one of the other drugs? Can I mix Diclofenac with a heat gel or a cooling gel? — Chameleon 07:43, 22 September 2007 (UTC)

Environmental impact when used in humans
We know about the devastating effect on vultures when diclofenac is used in veterinary medicine. Is there any evidence of environmental damage caused by its use in human medicine? I recently realised that it's the main ingredient in the anti-pain gel I've been using, and am not sure what to do. Perodicticus (talk) 11:04, 8 May 2008 (UTC)

It is the practice of the Parsi religion to leave bodies on platforms for vultures rather than burial or cremation. The idea is that the Sun purifies and the Sun path leads to heaven. They now use solar panels to heat the bodies because of the vulture crisis. Fairandbalanced (talk) 03:25, 12 September 2008 (UTC)

Drowsiness?
Diclofenac isn't described - here, in the product info i've seen, or online - as causing drowsiness or having any kind of sedative effect (that i can see). Yet when i took it, i definitely felt woozy, and a friend who has just started taking it independently reports the same. Are we imagining it? Is there any evidence for a sedative effect?

-- Tom Anderson 2008-06-20 1520 +0100 —Preceding unsigned comment added by 128.40.81.159 (talk) 14:20, 20 June 2008 (UTC)

dizziness mentioned here: http://www.medicinenet.com/diclofenac_sodium-oral/article.htm No idea fo their sources of info, but presumably there is something in it. —Preceding unsigned comment added by 82.152.215.176 (talk) 14:46, 1 July 2008 (UTC)


 * "Tiredness (sometimes extreme) and sleepiness" are listed as side effects in the 50mg sodium formulation I've been prescribed, and I've been bloody exhausted since I started taking it. You're not imagining it. Addition - Medline advises to stop taking it and discuss with your doctor if this occurs. 87.194.48.197 (talk) 23:16, 16 September 2008 (UTC)
 * Now that explains the million hours a day I spend sleeping! Mathmo Talk 03:24, 25 February 2010 (UTC)

The prescription bottle I have does have the "may cause dizziness and/or drowsiness, use caution when operating vehicles or heavy machinery" label on it, and the doctor warned me of it. --208.51.50.157 (talk) 02:34, 11 October 2008 (UTC)

Baltic states name
Where does the "NB: Diclofenac is known in the Baltic States as Diclofenacum." part come from? In Estonia it's referred to as diklofenak. Yogiz (talk) 18:38, 1 September 2008 (UTC)
 * Must be that Baltic states are the last ones in the world to use Latin names ? :D --Bstard12 (talk) 00:34, 11 December 2010 (UTC)

References in first three sections???
I was likewise pretty astonished to read about the vultures, but the references are there and maybe we should see if this could be one of the nifty Wiki factoids on the main page..??... More importantly, proper referencing in the first three sections of this article would improve it greatly. The very last references need to be wikified so they drop into the references rather than the text. Celia Kozlowski (talk) 12:52, 26 November 2008 (UTC)

Solaraze or Solareze?
Is the name really spelled Solareze as in the article (perhaps in English speaking countries)? There are 49.300 Google hits for "Solaraze" vs. 343 for "Solareze". --ἀνυπόδητος (talk) 17:09, 14 December 2008 (UTC)

Difnal?
I have a packet of Diclofenac Sodium 50mg tablets which seems to be marketed as "Difnal". The tablets were obtained at the Government Hospital in Kuala Lumpur, Malaysia. Masalih (talk) 16:24, 6 March 2009 (UTC) I have a few of these tablets left from a previous injury in 06. I hurt my foot and I remembered I have these for pain. The destroy date is 8/07. Will these still be good to take until I am able to see the dr. Monday? 67.162.17.32 (talk) 01:36, 1 August 2009 (UTC)
 * Wikipedia cannot give specific medical advice. -Wikid77 (talk) 09:18, 25 August 2010 (UTC)
 * Shelf life ain't medical advice where I come from --Bstard12 (talk) 00:36, 11 December 2010 (UTC)
 * Agree with Wikid, disagree with Bstard. Never thought I would write such a sentence. Le Prof 71.239.87.100 (talk) 01:47, 8 September 2014 (UTC)

= Topics from 2010-2011 =

World Wide Shortage of Diclofenac?
Every time I've been to the pharmacist in the past few months I've been told there is a world wide shortage, which is why they're stuggling to fill my prescription. I did a quick google search around but couldn't find anything, anybody got links? Mathmo Talk 03:27, 25 February 2010 (UTC)

Retrofit talk-page headers
I have inserted the year headers "Topics from 2005-2009" (etc.) and retro-fit headers for "Some side-effects" & "Effects on vultures" +signed, as the earliest topics entered on this talk-page. -Wikid77 (talk) 09:18, 25 August 2010 (UTC)

year patented? is it generic?
i think it is noteworth to know year patented and year became generic. 163.40.12.37 (talk) 16:40, 20 January 2013 (UTC)

Not a small increase in risk of heart disease
From the article:



A relative increase in risk from 1.0 to 1.63 (or 63% increase) is in my opinion not small. 85.164.124.207 (talk) —Preceding undated comment added 11:38, 24 June 2013 (UTC)

ZORVOLEX - a novel formulation
A new formulation of DICLOFENAC was just approved by the FDA in october of 2013. It is different from other formulations in that it was developed using SoluMatrix Fine Particle Technology(tm). An update to the original Wiki page should be made to reflect the addition of this drug formulation. There is a myriad of free data on the subject