Talk:Dicycloverine/Archive 1

Discussion
The old picture is wrong, I'm sure. Dicyclomine has two ethyls, not methyls on the amine. Replaced with correct diagram. See the empricial formula just about in any monograph, or in Clarke's Analysis of Drugs and Poisions for example (CAS 77-19-0). — Preceding unsigned comment added by 81.153.126.219 (talk) 19:11, September 5, 2004‎
 * My booboo, your diagram matches my pharm book. Musn't have been paying enough attention that day. Matt 05:42, 6 Sep 2004 (UTC)

'Intestinal hypermotility'? Is that another name for diarrhoea? Axl 13:55, 15 Nov 2004 (UTC)
 * IANAD, but I'm sure it could also be intestinal cramps in the upper abdominal area which could result in something short of diarrhea, like gassiness. --jibun≈παντα ρει≈ (keskustele!) 16:37, 28 June 2007 (UTC)

Changes and Additions
Hey all, I wanted to post this on here so everyone can take a look at it before I made any changes. I'm still very inexperienced with WP editing, so I don't wanna start screwing with anything yet. I'm studying this at the moment anyway, so I updated the clinical uses section to include the specific mechanism of action and the reason it's clinically useful. Another reason I'm posting this before editing is because I'm tired, and I'm afraid this sounds really pedantic and I don't want it to be too complex to be helpful. Any suggestions or changes are welcome. Dicyclomine is used to treat intestinal hypermotility, the symptoms of Irritable Bowel Syndrome (IBS) (also known as spastic colon). It relieves muscle spasms in the gastrointestinal tract by blocking the activity of acetylcholine (ACh) at the muscarinic acetylcholine receptor (muscarinic antagonist). Normal binding of ACh at the muscarinic receptor is a component of the parasympathetic autonomic nervous system, and this binding (amongst other effects) produces increased GI motility, which can exacerbate pathologies like IBS, in which a patient's GI tract is already damaged or sensitive. Blocking by dicyclomine results in a reduction of parasympathetic motility changes, causing relaxation of the smooth muscle that lines the GI tract, from the stomach to the colon. This causes an increase in both gastric emptying time and intestinal transport time. Besides being useful for treating IBS (which involves only the nervous system of the patient), dicyclomine is also useful for treating diarrhea caused by overdose of parasympathetic-activating drugs (known as parasympathomimetics), and to some extent, diarrhea caused by nonautonomic agents. Muscarinic blockers are in fact more efficacious at countering the effects of parasympathomimetics than endogenous parasympathetic activity. It is suggested that this is because parasympathetic neurons release ACh into a negative feedback loop. When the neuron releases ACh, the neurotransmitter binds to a receptor on the same neuron that slows ACh release...effectively, the neuron checks its own activity already, so antimuscarinics don't have much to do. This One point that must be emphasized (especially to dispel patient fears) is that neither dicyclomine nor any muscarinic antagonist, even at concentrations sufficient to completely block muscarinic receptor activity, will cause total cessation of GI motility. Since the GI tract is innervated by the enteric nervous system (sometimes referred to as the "gut brain"), the lack of parasympathetic stimulation will be compensated for by local hormonal and noncholinergic neuronal control.

Source: Katzung, Bertram. Basic and Clinical Pharmacology, 10th edition. Copyright 2007 by The McGraw-Hill Companies, Inc. (lemme know if i forgot anything here) Cheers, Ohnoitsthefuzz (talk) 16:09, 7 February 2008 (UTC)