Talk:Dihydrofolate reductase

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Nhattrongdo, Bekidl, Yinfj16. Peer reviewers: Kkentala, Cpwatkins, Jadewey.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 19:31, 16 January 2022 (UTC)

Inhibtors for DHFR
Trimethoprim and derivates is only an inhibitor for bacterial DHFR Methotrexat is inhibitor for human DHFR --Maxebert (talk) 03:22, 8 July 2009 (UTC)

Split out new article for DHFR inhibitors
Worth moving some content to start Dihydrofolate reductase inhibitor ? Rod57 (talk) 18:18, 5 January 2009 (UTC)

More information on the mechanism
Compared to other sections, the mechanism of DHFR is underrepresented.Yinfj16 (talk) 01:35, 23 February 2017 (UTC)

Recent research missing
Key word like "conformation coupled catalysis" is missing in this article.Yinfj16 (talk) 01:47, 23 February 2017 (UTC)

Insufficient information about the studies on the mechanisms of the enzyme
Most of the information in the article is not from recent research papers, particularly the mechanism section


 * Most of the information should NOT come from research papers. Per WP:PSTS, secondary sources (i.e., review articles) are strongly preferred. The reason for this is an astonishing high percentage of primary research cannot be repeated.  Second, the notability of a results in a primary source is questionable.  Much better to clte recent independent review articles in which the results are summarized and compared with other primary literature. This increases both the reliability and notability of the conclusions. There are tons of recent reviews on this enzyme, so there is no excuse not to use these sources. Finally this article is about an enzyme, not research about the enzyme. Wikipedia articles should simply state facts. Boghog (talk) 09:01, 12 March 2017 (UTC)

Suggested changes to the article
The article should have some more information on the mechanism such as the residues involved in the conformational changes of the enzyme, how the substrate and the cofactor bind to the enzyme, some critical factors that can interfere with the mechanisms of the enzyme — Preceding unsigned comment added by Nhattrongdo (talk • contribs) 18:04, 28 February 2017 (UTC)

Suggested correction to the article
The article seems to interpret the reference incorrectly where it claims that " ... and severe cerebral folate deficiency which can be corrected by folinic acid supplementation." The referenced article  states that: "Cerebral BH4 deficiency was noted in the proband. It was not corrected by folinic acid and could explain some of the residual neurological symptoms. The absence of hyperphenylalaninemia in our patients indicates that BH4 deficiency was primarily cerebral and was not due to any of the known causes of systemic BH4 deficiency. BH4 is a cofactor for phenylalanine-4-hydroxylase, tyrosine-3-hydroxylase, and tryptophan-5-hydroxylase, and it is required for the production of monoamines, including dopamine, serotonin, and norepinephrine.20 Of note, in the proband, CSF homovanillic acid (a major catecholamine metabolite) and 5-hydroxyindoleacetic acid (a serotonin metabolite) levels were slightly low and remained in the low-normal range after folinic acid treatment. 5-MTHF prevents peroxynitrite-induced BH4 oxidation in blood vessels. Thus, the low cerebral BH4 level in our patient could indicate a similar role for 5-MTHF in the CSF or brain." — Preceding unsigned comment added by ENAMELT (talk • contribs) 19:43, 5 February 2018 (UTC)

R67 pic needs replacement
I count one chain and no ligands. No good. Artoria2e5 🌉 17:42, 21 February 2023 (UTC)


 * 2rk1 pic gives ligands, but no biological assembly. Still needs replacement. Artoria2e5 🌉 14:30, 22 February 2023 (UTC)