Talk:Dihydromorphine

Dihydromorphine used in Czech Republic or Slovakia?
"...though still perhaps relatively rarely, in Europe but has in fact been used more and in greater overall quantities in recent decades in some countries such as the Czech Republic, Slovakia and others in the region." Well. I'm quite familiar with analgesics used in Czechoslovakia, Czech and Slovak Republics, and as far as I know (from 1970 until now, at last), dihydromorphine was used neither in a commercial preparation nor in any magistraliter preparations in medicine in Cz/Sk whatsoever. If noone provides a reliable source for this statement, I'll delete it in a day or two.--84.163.126.131 (talk) 19:30, 12 February 2008 (UTC)
 * I can even list all opioids used in the CSSR until 1990:
 * Morphine; Codeine; Ethylmorphine; Hydrocodone; Oxycodone; Pholcodine (Neocodin); Omnopon/Pantopon; Pethidine (Dolsin); Methadone (Mecodin); Piritramide (Dipidolor); Bezitramide (Burgodin); Opium and its Preparations (Tinct. Opii, Pulvis Opii); Fentanyl, Alfentanil and Sufentanil; Tilidine; Tramadol; Propoxyphen and Dextropropoxyphene; Pentazocine; Butorphanol; Nalbuphine; Buprenorphine. Some were discontinued prior to 1990, some introduced in the late 1980's (Rapifen, Sufenta, Buprenorphine). Nowadays, the range of opioids marketed is comparable to that of other EU lands. If I missed some, a correction is wellcomed.--84.163.126.131 (talk) 19:42, 12 February 2008 (UTC)

Dihydrocodeine article and "dihydromorphine-6-glucuronide"
Besides Dihydromorphine being a metabolite of Dihydrocodeine (in much the way morphine is a metabolite of codeine) it also lists a "dihydromorphine-6-glucuronide" as a metabolite, and says that it is "one hundred times more potent" (than Dihydrocodeine) but negligible in effect due to how little is created as a metabolite. Well if Morphine-6-glucuronide is a metabolite of morphine, following the rule where one comes after the other might dihydromorphine-6-glucuronide also be a metabolite of this article's Dihydromorphine and not just of Dihydrocodeine as stated in its own article? Maybe such is made of Normorphine and such as well? (Normorphine-3,6-glucuronide... 6- being the active and important one). I wonder what other Such&SuchMorphine-6-glucuronides there are (arising I am assuming) from the non-ester/etherized (pro-drug type) semi-synthetics that exist of morphine(?), and are they all such magnitudes more potent? Could the glucuronide branch be added to and made more into a pro-drug, lipid soluble? Does it even need to or does it cross the BBB by itself? Many questions. Nagelfar (talk) 14:33, 17 October 2009 (UTC)