Talk:Dipeptidyl peptidase-4 inhibitor

I'm confused - first posting. The image suggests that DPP-4 inhibits GLP-1, but the text says differently.

Deception or drug industry pushing?
Big question: I was recently sent to the E.R. on a unrelated to my type 2 diabetes, and they promptly hit me up with insulin (i take metformin), a week later i saw my G.P. and told her about my non desire not to be stuck with a injection jones the duration of my life. She looked at the Metformin doseage and said: ''This is the start up dose" and uped the mg's and i got time released new meds. I just read about Januvia and wonder what are these medical people thinking? If it's proven to assist the metformin, why has it been witheld from me? Why are they so anxious to see me shoot that insulin up at a hospital? Why didn't they try and raise my dose of metformin? I wasn't in trauma, i was sent there in case i needed a procedure that couldn't be done at my Gastro's shop. Im getting very frustrated with people who claim to be helping me and are taking shortcuts. From Austin, Texas jeff—  —Preceding unsigned comment added by 72.177.62.149 (talk) 23:39, 25 September 2007 (UTC)

Possible cancer risk ?
This section of the article seems to have undue prominence since presumably the clinical trials prior to FDA and EU approvals have not shown increased cancer risk. Are clinicians still worried about this ? Rod57 (talk) 14:55, 27 November 2009 (UTC)
 * Saw a drug rep in a medical clinic for Nesina; heard about cardioprotective effects. never heard about its cause in pancreatic cancer. Excellent contribution 129.180.137.60 (talk) 12:33, 2 April 2014 (UTC)

Description of Pharmacological Action
There is a case for avoiding the use of the term "oral hypoglycaemic" which tends to infer that the medicine will cause hypoglycaemia. It is better to use the term oral antidiabetic drug or similar. — Preceding unsigned comment added by Smokingunnz (talk • contribs) 05:40, 23 October 2013 (UTC)
 * From a medical standpoint, that's just what we call it. Hypoglycemic means to reduce blood sugar. That's why hypoglycemic attacks occur in people with diabetics... because they take insulin, and they don't have sufficient food with it, say. And this causes a hypo attack. All patients have this from time to time, and it's very, very bad. You never want to get it 129.180.137.60 (talk) 12:34, 2 April 2014 (UTC)

Review
... in Endocrine Reviews 10.1210/er.2014-1035 (DOI not switched on yet, but probably soon). JFW &#124; T@lk  17:07, 14 September 2014 (UTC)

Risk of heart failure - now recognised
The intro says "A recent meta analysis found no favorable or harmful effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, or stroke, but a marginally statistically significant increase in heart failure.[5]" which now seems out of date. The news here is that the FDA (finally) added heart failure warnings to some of these drug labels. See Side effects - which uses Diabetes Meds Containing Saxagliptin and Alogliptin Linked to Increased HF. - Rod57 (talk) 12:36, 28 April 2016 (UTC)

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