Talk:Drug interaction

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Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 February 2019 and 5 May 2019. Further details are available on the course page. Student editor(s): Mhayes2019.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 19:52, 16 January 2022 (UTC)

Definition
Regarding this line: Drug interaction is a situation in which two or more separate drugs have been absorbed into the body, shouldn't drug interation take into account reactions that occur outside the body? For example, in mixed drip bags? Thisis what we are taught in our pharmacology classes, at any rate, and I was wondering if anyone can shed some light on this. Kilbosh 09:16, 11 June 2006 (UTC)
 * You are right, so be bold and add what you learned in to the article. However, I would think that what happens in the mixed drip bags is more a matter of Pharmacy than Pharmacology.   A n d r e a s    (T) 16:05, 11 June 2006 (UTC)
 * I think that generally is not ment by this term.--Steven Fruitsmaak | Talk 21:51, 10 August 2006 (UTC)
 * Stephen is correct. The situation you're referring to, Kilbosh, is called chemical incompatibility. Drug interactions involve the interaction of a drug with something else (e.g. another drug, an herb/vitamin, a disease state) in the body. Drug interactions are matters of pharmacokinetics/pharmacodynamics, while compatibility is a matter of stability and solubility. E.g. the combination of grapefruit juice and simvastatin is a drug interaction (drug-food interaction), whereas ceftriaxone sodium and lidocaine are chemically incompatible but do not have a drug interaction in the body; i.e. you can treat endocarditis with IV cetriaxone and treat pulseless ventricular tachycardia with IV lidocaine at the same time in a patient, as long as the drugs are in separate bags. Biochemistry&#38;Love (talk) 16:41, 11 December 2016 (UTC)

Interactions with withdrawn drugs
I saw some recent news coverage of people suffering toxicity from levamisole in cocaine in the U.S., and I noticed that a few of the well-known fatalities were people who had also been under the influence of alprazolam (Xanax). Of course, a couple of cases are not scientific evidence. But as levamisole was withdrawn in the U.S. and some other countries during the past decade, I have to wonder: would anyone keep records on such an interaction? Wnt (talk) 18:31, 1 June 2010 (UTC)

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"Underlying factors" Source
This sentence, "By studying the conditions that favour the appearance of interactions it should be possible to prevent them or at least diagnose them in time," now references the following source: Ganeva M, Gancheva T, Troeva J, Kiriyak N, Hristakieva E. "Clinical Relevance of Drug-Drug Interactions in Hospitalized Dermatology Patients". Adv Clin Exp Med 2013, 22, 4, 555–563 ISSN 1899–5276. Although the authors discuss polypharmacy (number of systemic drugs), the paper doesn't seem to be relevant to the above quote. Thoughts? Biochemistry&#38;Love (talk) 04:01, 13 April 2017 (UTC)


 * Thanks for reverting the addition of this questionable source. This seems to be a case of trying to shoehorn in a citation rather than contributing the article by adding material that is supported by reliable source.  The source in question  is primary.  Per WP:MEDRS, secondary sources are preferred. Worse yet, the source is narrowly confined to dermatology.  IMHO, a completely inappropriate source. Boghog (talk) 18:12, 13 April 2017 (UTC)
 * hi
 * @Boghog 102.88.44.144 (talk) 18:52, 3 May 2023 (UTC)

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