Talk:Dysplasia

Editing
Sorry if I screwed up the set up of the page, but this whole thing is quite new to me. I am a working cytotechnologist so this is a topic near and dear to my heart.


 * Go ahead! Very pleased to have you work on such a tricky article. JFW | T@lk  11:16, 10 August 2005 (UTC)


 * I rewrote the page to broaden its scope and differentiate 'dysplasia' from 'CIN'. Keep writing, MsSmith, your contribution is very precious. Emmanuelm 21:19, 10 January 2006 (UTC)

Error?
Forgive me if I am wrong, but CIN cannot be diagnosed with a pap smear/LBC. Cytology only shows dyskaryosis which can be said to be consisten with CIN I, II or III. Colposcopy/biopsy is required to stage CIN. —Preceding unsigned comment added by 81.151.141.8 (talk) 01:16, 16 November 2007 (UTC)

Additional comment: The text seems to imply that a pap smear can be used to diagnose any dysplasia or carcinoma. To my knowledge, It is only used in cervix cancer caused by Human Papilloma Virus HPV. To make a diagnosis you need a (preferrably rough-) needle aspirate of the tissue or other tissue sample. Andbir (talk) 21:16, 19 May 2008 (UTC)

Consider addding some reference to staging vs. grading taxonomy? Andbir (talk) 21:16, 19 May 2008 (UTC)


 * Thank you for your suggestion. When you feel an article needs improvement, please feel free to make those changes. Wikipedia is a wiki, so anyone can edit almost any article by simply following the  link at the top. The Wikipedia community encourages you to be bold in updating pages. Don't worry too much about making honest mistakes — they're likely to be found and corrected quickly. If you're not sure how editing works, check out how to edit a page, or use the sandbox to try out your editing skills.  New contributors are always welcome. You don't even need to log in (although there are many reasons why you might want to)..  WhatamIdoing (talk) 19:36, 29 May 2008 (UTC)

Dysplasia vs. Carcinoma?
The term Dysplasia does not infer that epithelial cells are involved, whereas carcinoma does? Andbir (talk) 21:10, 19 May 2008 (UTC)

Dysplasia is a more generic term in describing the cells. Carcinoma is the term applied to epithelial cells only. Connective tissue neoplasm such as muscle and fat are Sarcomas. Hematologic neoplasms are leukemias or lymphomas. (140.142.84.62 (talk) 18:38, 23 June 2009 (UTC)docjenn)

Clarification needed?
As a student trying to learn about Dysplasia this article was extremely helpful. Unfortunately the paragraph on "Screening" is confusing (e.g. "physicians expect dysplasia to occur at the same rate in a typical individual as it would in many other people".   I suggest  substitute "population as a whole" or "general population" or "the masses" for "many other people".     — Preceding unsigned comment added by 147.70.170.129 (talk) 23:28, 30 July 2013 (UTC)

In the first paragraph: "This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells." it is unclear to me how mature cells can manifest with a decrease in their location... Perhaps clarifying that passage would be helpful to others? — Guillaume Pelletier ~ 14:39, 10 November 2010 (UTC)

Misplaced comment
I have removed this text:


 * [Liddell, Scott-Jones, the standard and ultimate English-Greek lexicon, has no entry for δυσπλασíα; the Greek verb πλáθω means "to draw near," a poetic form of the verb πελáζω. My guess is that the verb should be πλáσσω, "to form or mould," properly used of artists who work with earth, clay, or wax and the source of the English word "plastic."]

from the lead, where it does not belong. WhatamIdoing (talk) 02:53, 22 October 2011 (UTC)

Decrease in location?
“decrease in the number and location of mature cells” -- this doesn't make sense to me. --Gaborgulya (talk) 09:31, 18 June 2013 (UTC)


 * I think you have to take it as a whole piece: "This generally consists of an expansion of immature cells...with a corresponding decrease in the number and location of mature cells."  So imagine that you have a sample that contains 100 cells.  If the number of immature cells is expanding, then there isn't enough room to have the normal number of mature cells.
 * I'm not sure what the "location" bit refers to, though. WhatamIdoing (talk) 19:13, 20 June 2013 (UTC)

Confusion
Many confusions in this article between the generical ambiguous term "dysplasia" and the "epithelial dysplasia" (now called "Intraepithelial neoplasia"). Humpath (talk) 17:01, 4 May 2014 (UTC)

Stuff we might cover
Wall St Journal story, and related "Overdiagnosis and Overtreatment in Cancer: An Opportunity for Improvement", Laura J. Esserman, MD, MBA1; Ian M. Thompson Jr, MD2; Brian Reid, MD, PhD3, JAMA. 2013;310(8):797-798. doi:10.1001/jama.2013.108415. Wiki CRUK John (talk) 12:59, 15 September 2014 (UTC)

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Macroscopic changes not seen in MDS
The introduction states that macroscopic (= without use of microscope). MDS is diagnosed seeing morphological and microscopically changes in bone marrow or blood cells (hematopathologist here). Lufthoved (talk) 20:43, 3 September 2023 (UTC)