Talk:Dz13

Protected edit request on 5 December 2019
Change: under ”Mechanism of action”; include: It has been reported off-target effects of Dz13, not related to the inactivation of c-Jun

Change: under “References”; include:

Change: under “Investigations”, before the sentence “A series of investigations”; include: Six of Khachigian's research articles have been retracted and one corrected due to unresolved concerns over missing or manipulated data.

Change: under “Investigations”, end of paragraph; include: “This conclusion has been challenged”.

Reason for change: important to include more information from another point of view. Moroks (talk) 13:28, 5 December 2019 (UTC)
 * Red information icon with gradient background.svg Not done for now: please establish a consensus for this alteration before using the template. &mdash; Martin (MSGJ · talk) 22:33, 5 December 2019 (UTC)

Protected edit request on 10 December 2019
Change: Under the headline “Mechanism of action”; include as the third paragraph:

Oligonucleotides such as Dz13 may be used with carriers such as cationic polymers for improved cellular delivery and efficacy. Dz13 in such polymers inhibits tumor cell proliferation and migration by suppressing levels of c-Jun and MMPs, reduces H1N1 and H7N2 viral replication and increases survival of mice infected with influenza A and suppresses c-Jun and solid tumor growth in biomimetic nanoballs. Dz13 has also been used in dermal drug delivery systems for enhanced skin penetration of DNAzyme.

Under “References”; include:

Reason for change:

Provides critical information on Dz13 from different laboratories.

Moroks suggested on 5 December 2019 to “Change: under “Investigations”, before the sentence “A series of investigations”; include: Six of Khachigian's research articles have been retracted and one corrected due to unresolved concerns over missing or manipulated data. [4] [5] [6]”. This sentence should not be included since it is neither relevant nor factual as explained below.

Reasons for not inserting Moroks’ proposed sentence:

(a) Only one (1) of the 6 retracted articles relates to Dz13. This is the “2010 paper” already noted in the existing first sentence “In 2013, trials of Dz13 …”. It is mischievous to refer to the 5 other papers on this page as these do not relate to Dz13; (b) None of the publisher retraction notices for any of these 6 research articles refer to manipulated data; (c) Although data manipulation was initially alleged, the independent expert panels investigating this article found genuine error or honest oversight, not deliberate or intentional conduct. — Preceding unsigned comment added by HansonPeabody (talk • contribs) 21:17, 10 December 2019 (UTC) HansonPeabody (talk) 21:22, 10 December 2019 (UTC)HansonPeabody (talk) 21:23, 10 December 2019 (UTC)HansonPeabody (talk) 21:24, 10 December 2019 (UTC) HansonPeabody (talk) 21:31, 10 December 2019 (UTC)

Protected edit request on 10 December 2019 (signed)
Change: Under the headline “Mechanism of action”; include as the third paragraph:

Oligonucleotides such as Dz13 may be used with carriers such as cationic polymers for improved cellular delivery and efficacy. Dz13 in such polymers inhibits tumor cell proliferation and migration by suppressing levels of c-Jun and MMPs, reduces H1N1 and H7N2 viral replication and increases survival of mice infected with influenza A and suppresses c-Jun and solid tumor growth in biomimetic nanoballs. Dz13 has also been used in dermal drug delivery systems for enhanced skin penetration of DNAzyme.

Under “References”; include:

Reason for change:

Provides critical information on Dz13 from different laboratories.

Moroks suggested on 5 December 2019 to “Change: under “Investigations”, before the sentence “A series of investigations”; include: Six of Khachigian's research articles have been retracted and one corrected due to unresolved concerns over missing or manipulated data. [4] [5] [6]”. This sentence should not be included since it is neither relevant nor factual as explained below.

Reasons for not inserting Moroks’ proposed sentence:

(a) Only one (1) of the 6 retracted articles relates to Dz13. This is the “2010 paper” already noted in the existing first sentence “In 2013, trials of Dz13 …”. It is mischievous to refer to the 5 other papers on this page as these do not relate to Dz13; (b) None of the publisher retraction notices for any of these 6 research articles refer to manipulated data; (c) Although data manipulation was initially alleged, the independent expert panels investigating this article found genuine error or honest oversight, not deliberate or intentional conduct. HansonPeabody (talk) 21:33, 10 December 2019 (UTC) HansonPeabody (talk) 21:33, 10 December 2019 (UTC)