Talk:Epithelial–mesenchymal transition

Wiki Education Foundation-supported course assignment
This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Cs109809.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 20:46, 16 January 2022 (UTC)

EMT first recognised...
I'm currently writing my dissertation on a protein in EMT and my literature review has come up with a review article by Polyak and Weinberg (2009, Nature Reviews: Cancer), highly respected in this field, and says: "EMT transdifferentiation programme was first described as a cell culture phenomenon and its relevance to in vivo physiological processes was long debated"

The wiki article says that EMT was first recognised in gastrulation.

I haven't time to check this at the moment but if anybody has the time please do confirm which is correct. 93.96.60.125 (talk) 12:55, 7 January 2013 (UTC)

Could mention platelets re cancer metastasis
[http://www.cell.com/cancer-cell/retrieve/pii/S1535610811003564 Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis. 2011] - Rod57 (talk) 15:30, 11 February 2013 (UTC)

Section on Generation of endocrine progenitor cells from pancreatic islets could move to another article
The paragraph (now subsection) Generation of endocrine progenitor cells from pancreatic islets seems too detailed for this article and more suitable for its own article or as a section in diabetes/islet therapy. - Rod57 (talk) 15:41, 11 February 2013 (UTC)

Involved in wound healing
Epithelial-mesenchymal_transition_TGF-_and_osteopontin_in_wound_healing_and_tissue_remodeling_after_injury, [http://www.ncbi.nlm.nih.gov/pubmed/20304956 Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2. 2010], [http://link.springer.com/chapter/10.1007%2F0-387-28671-3_8?LI=true Cutaneous Wound Reepithelialization. 2005] - could be mentioned ? - Rod57 (talk) 15:57, 11 February 2013 (UTC)

Enabler of mesenchymal-type cancer cell mobility
[http://www.biosignaling.com/content/pdf/1478-811x-8-23.pdf "Rac and Rho GTPases in cancer cell motility control" 2010. Matteo Parri, Paola Chiarugi.] discusses cancer cell mobility after an EMT. - Rod57 (talk) 06:26, 12 February 2013 (UTC)

Epithelial-myeloid transition
A recent review has suggested that EMT of cancer cells should be reclassified as Epithelial-Myeloid Transition. This is based on the osteomimetic properties of cancer cells amongst other things. The markers often used to identify the transformed cancer cells as mesenchymal (vimentin, fibronectin, N-Cadherin, alphavbeta3-integrins and FSP-1) are all also found in myeloid cells. Moreover the "mesenchymal" cancer cells often exhibit behaviours more similar to the myeloid cells macrophages and pre-/osteoclasts. See: http://www.jcancer.org/v05p0125.htm

Critique of Epithelial-mesenchymal transition for PBIO 5180
Content- I think that some of the material in the article is organized and focused, however, once the article begins discussing the role of EMT in cancer progression and generation of endocrine progenitor cells from pancreatic islets it becomes much less fluid. I believe more and better examples exist that describe EMT in many types of cancer. A section should also be added that discusses the ability of cancer cells that have undergone EMT to resist chemotherapeutics. I believe the presentation is understandable and the way the article is written now I can see the logical progression from one section to the next. I believe the articles covers this topic only partially/as an overview because it discusses EMT in cancer but does not expose differences in EMT for different cancers and how this affects expression of important cell adhesion proteins. Different cancers may undergo EMT due to different signals and may be likely to metastasize to certain areas in the body depending on the presentation of cell surface proteins. The quality of the evidence seems pretty good as I see some citations from Nature Reviews and the Journal of Pathology as well as the addition of some new information from 2017. There are a lot of citations from primary research articles but not nearly as many medical references. This article could use more medical references. The articles has 58 references listed and most of them are primary research articles from multiple authors studying EMT in different cancers. I do not see any outright assumptions in the article but I do see several interpretations of what effects cancer cells gain in terms of metastatic ability as a result of EMT. The content of this article could be improved by 1. Adding a section discussing how EMT in cancer cells effects their chemoresistance 2. Discussing the role of EMT in regulating the expression of metastatic adhesion molecules on the surface of cancer cells 3. Expanded section discussing partial EMT phenotype 4. Fixing grammatical and sentence structure mistakes 5. Discussing the relationship between EMT and cancer stem cells. Quality - The article does have a pretty well put together introduction, however, I would add a connection between how cells switch back and forth between the epithelial and mesenchymal states during embryogenesis using EMT and its reverse process MET. I might also add a sentence as to why the transition is necessary for proper embryonic development. The introduction is understandable as written and does a decent job at summarizes the key points. I might add a little more summary of the role of EMT in the 3 different cell types in the introduction. Yes there are several headings and subheadings, however, I would split up some the subheadings in order to separate two distinct ideas so the reader does not get confused and can find the area related to EMT they are interested in much faster. There are things missing in this article such as other examples of EMT inducers for the table presenting initiators of EMT. Other things that are missing include diagrams/pictures of EMT in cancer metastasis and figures of EMT in wound healing and fibrosis. The article does have 3 useful images in the appropriate places, however, I would add more diagrams to illustrate EMT in the 3 cell types. The article has the appendices and footnotes at the end. I think the coverage of the article is generally unbiased until the "Generation of endocrine progenitor cells from pancreatic islets" section as this section primarily cites one article to say findings were confirmed for human islet beta cells undergoing EMT. I do not think that you can definitively claim this from one article and I would seek out other articles that support or refute this finding. Facts are emphasized throughout this articles as there are over 50 references and most of the claims have multiple sources (mostly from primary research articles or review articles) to support the factual claims. I believe the references are reliable sources as a number of them are Nature Reviews papers which hold a lot of credibility in the scientific community. The references also include experts in the field that I am aware of, including Dr. Robert Weinberg. Other references cited by this articles are from well-respected scientific peer-reviewed journals such as the Journal of Pathology, Journal of Cell Biology, and the Journal of Clinical Investigation. Cs109809 (talk) 22:17, 23 October 2017 (UTC)

====

Inducers
Proposed adding doi:10.18632/oncotarget.22432 as a citation for the sentence: "Similarly, TGF-β activates the expression of SNAIL and ZEB to regulate EMT in heart development, palatogenesis, and cancer." The reference article is a peer commentary in a peer-reviewed journal, and as I've noted that this page has been flagged for needing better references, I'm sensitive to the fact peer commentaries are a disputed area and should be evaluated on a case-by-case basis as whether they are reliable sources. Also, please note above that this is a paid edit. Cglife.trummler (talk) 21:19, 14 December 2017 (UTC)

Organ Fibrosis
The summary at the top of the page states that EMT plays a role in wound healing, organ fibrosis, and metastasis. Later, EMT in wound healing and metastasis are both discussed in detail, but EMT in organ fibrosis is not elaborated on. I think it would be useful to include a section addressing the role of EMT in organ fibrosis within the article, as it would shed greater light on the topic of EMT. If someone is familiar with EMT and organ fibrosis, I would appreciate their contribution to this article. — Preceding unsigned comment added by 150.199.185.253 (talk) 13:42, 25 June 2018 (UTC)