Talk:Ethanol metabolism

Important Omissions
Needs to include the role of CYP450 proteins (esp CYP2E1) in the ethanol - acetaldehyde reaction. This is very relevant to anyone more interested in clinical significant over organic chemistry — Preceding unsigned comment added by 108.162.182.183 (talk) 18:20, 17 January 2012 (UTC)

Writing Style
Somebody needs to translate this into English. It's the worst article on Wiki I've ever read. —Preceding unsigned comment added by 83.104.48.201 (talk) 19:58, 3 October 2009 (UTC)

This article seems written like a wikibook 70.83.165.112 03:37, 3 December 2007 (UTC)
 * It seems to me that this is a copy of a lab report. 71.167.118.89 (talk) 12:36, 7 January 2008 (UTC)
 * Yeah, this is honestly really poorly written (in the sense of organization and Wikipedia). I'm going to mark this for later review so I can maybe make some sense of this. Slavakion (talk) 03:01, 9 February 2008 (UTC)

i agree merge this with ‘microsomal ethanol-oxidising system as well, keep all the data on the topic in one place 125.253.101.232 (talk) 02:04, 27 March 2013 (UTC) I made a couple edits to make this article more like one that belongs on Wikipedia, but it still needs a bit of work. I tagged it appropriately. Andrew Nutter    Talk |  Contribs 15:47, 20 April 2009 (UTC)

"all the way back to single cell bacteria." ?Is there any other type of bacteria? --Thebesius (talk) 06:18, 2 November 2012 (UTC)

References & Original Research
This article at least seems to be fairly well cited. Do we really need that tag? What exactly is the information in question? Andrew Nutter    Talk |  Contribs 15:47, 20 April 2009 (UTC) I think the line in question may be: "If the body had no mechanism for catabolizing the alcohols, they would build up in the body and become toxic. This could be an evolutionary rationale for alcohol catabolism" maybe a few other places? Editsbyabigail (talk) 23:52, 12 November 2013 (UTC)

glycolysis map
Ethanol doesn't even get used in glycolysis ... the whole glycolysis map is really misleading because the conversion of acetic acid into acetyl-CoA is an aerobic step, not an anaerobic one. I suggest we remove it and replace it with a simpler schema. It doesn't add anything that we don't already know through the "thermodynamic considerations" section. John Riemann Soong (talk) 14:08, 16 August 2009 (UTC)

Excretion
a section is needed on excretion. i.e., proportion excreted by the kidneys unchanged, as acetaldehyde, etc.Toyokuni3 (talk) 15:17, 9 June 2010 (UTC)

Way to test for enzyme?
Is there a way to test someone to see if they have the enzyme or not? — Preceding unsigned comment added by 140.147.236.194 (talk) 16:06, 25 May 2012 (UTC)

Energy Calculations
Step 3 is missing in the energy calculation section. I do not know enough about wikipedia formatting or biochemistry to fix it. — Preceding unsigned comment added by 71.197.187.251 (talk) 06:32, 5 February 2013 (UTC)

Energy calculation error: it seems to me that the maximum has to be the total of the full pathway, 47.2 - 215.1 - 1 325.3 = -1493.2 and the minimum still requires the first endothermic step 47.2 - 215.1 = -167.9 I have made this adjustment, although I am happy to be proven wrong as I am an engineer not a biochemist. Mike163 (talk) 14:53, 2 January 2016 (UTC)

My bad: reviewing the calculations, I didn't see the Sigma initially.Mike163 (talk) 15:13, 2 January 2016 (UTC)

Biologically accessible energy
Most of the −1325.6 kJ/mol calculated here will be turned into heat. Wouldn't it be more useful to list the biologically available energy produced per ethanol?

Given that NADH oxidation in the ETC cycle produces ~2.5ATP/NADH and ~1.5ATP/FADH2, this makes ~15 ATP available per ethanol. In comparison, glycolysis produces ~32 ATP/glucose. --Quantum7 13:25, 26 July 2017 (UTC)