Talk:Ethyl eicosapentaenoic acid

Additional information
In the section on Cardiovascular diseases, diabetes following the first paragraph on the JELIS trial (ending with the phrase "...apparently through mechanisms independent from regulation of lipid metabolism") please add:

E-EPA has been approved by the FDA as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with very high triglycerides (VHTG) or severe hypertriglyceridemia, defined as TG ≥500 mg/dL. When used to reduce very high triglycerides, the FDA-approved prescription E-EPA-only omega-3 fatty acid product was not associated with increases in LDL-C as compared to placebo in a clinical trial. Prescription and supplement omega-3 fatty acid mixtures that contain docosahexaenoic acid (DHA) may elevate LDL-C.

In the next paragraph, after the sentence ending "... and its cardiovascular complications, such as coronary artery disease and thickening of carotid arteries." please add the following sentences:

E-EPA has been shown to benefit endothelial function and lipid peroxidation in humans, both of which are associated with atherosclerosis. Due to its potent antioxidant effects, E-EPA uniquely reduces lipoprotein oxidation in-vitro. Further, improvements in endothelial function, represented by changes in nitric oxide (NO) release, alone and in combination with statin, have been observed with E-EPA. When tested in vitro in model membrane lipid vesicles, EPA, but not other TG-lowering agents tested in this model, inhibited the formation of cholesterol crystalline domains associated with atherosclerosis.

- — Preceding unsigned comment added by 5020QVRoad (talk • contribs) 13:27, 21 April 2015 (UTC)


 * is great. Using it. Jytdog (talk) 23:53, 31 March 2016 (UTC)
 * is good but is better.  Using that.  Jytdog (talk) 02:37, 1 April 2016 (UTC)
 * the rest appear to be primary sources or opinion pieces and not useful per WP:MEDRS Jytdog (talk) 02:55, 1 April 2016 (UTC)

article cleanup
Note - this article was not written per the community's standards for article about health - WP:MEDMOS for style and WP:MEDRS for sourcing, and I'm fixing it. There also was a lot of content in here about Eicosapentaenoic acid which is distinct from the subject of this article... and many of the sources were very old, and primary. i will build back up the Research section from recent reviews. Jytdog (talk) 21:13, 31 March 2016 (UTC)

note on related article discussions
See discussions at Talk:Omega-3 fatty acid about making all these fish oil/omega-3 articles make sense across Wikipedia. Am not going to restore "research" until that gets worked out, as the same content is already in a bunch of different articles. Jytdog (talk) 00:52, 1 April 2016 (UTC)