Talk:Eucalyptol

Toxicity
Does anyone have data on the toxicity and biopharmacology of Eucalyptol? —Preceding unsigned comment added by 203.214.95.150 (talk) 00:40, 18 October 2007 (UTC)

"Eucalyptus oil" is not "Eucalyptol"
I notice that Eucalyptus oil has been redirected to Eucalyptol. Eucalyptol or cineole is the major isolate of standard Eucalyptus oil, but the two are not the same. "Eucalyptus oil" is a generic name for oils specifically from Eucalyptus species only. It would be like saying that citronella oil is the same citronellal - which they are not. So I propose that we separate "Eucalyptus oil" and "Eucalyptol" into seperate headings. John Moss (talk) 11:00, 30 May 2008 (UTC)

WikiProject Food and drink tagging
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Please do not auto-direct the topic of....
Martindale: The Extra Pharmacopoeia to other pages, as it is an unique book--222.67.204.146 (talk) 10:44, 5 July 2009 (UTC)

MSDS reference contains no mention of what it's supposed to reference
The MSDS reference is provided as a citation for the claim that it is a reproductive hazard for males and females, yet in the MSDS itself the only hazards it lists are eye/skin irritant. The reference does not support the claim.... 128.163.8.163 (talk) 17:28, 27 September 2012 (UTC)

Assessment comment
Substituted at 14:44, 29 April 2016 (UTC)

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Eucalyptus was used as as decongestant plus
Cough drops used to contain eucalyptus oil as.decongestant but the menthol was cough suppressant and analgesic. Reaction with water & sulfuric acid gave "Terpin Hydrate" which was the distinctive taste of traditional Codeine cough syrup. And I assume the reason for removing Eucalyptus oil from cough drops is its a common allergen. Shjacks45 (talk) 10:50, 4 July 2019 (UTC)

Tea tree oil citation
Here’s a citation for its presence in Melaleuca alternifolia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360273/ … sorry I don’t have time to figure out all the proper formatting just now. — AlexBayleaf 58.96.87.140 (talk) 09:28, 3 July 2022 (UTC)

Revert struggle on biosynthesis
The biosynthesis of eucalytol can be described concisely. Linalyl pyrophosphate, which the editor refuses to link, converts to eucalytol as mediated by an enzyme cineole synthase. Its not complicated, in fact kind of routine: linalyl pyrophosphate is a common precursor to many terpenes and terpenoids.

Like almost all terpene conversions, the synthase mediates the formation and rearragement of carbocations. That is the "magic" of terpene biosyntheses. Racemic eucalytol is produced. One editor seeks to depict the proposed pathway for each enantiomer, which is redundant and the resulting image is difficult to read. The same editors wishes to describe the excruciating details of conformational changes and the hydrolysis of the ultimate carbocation. A number terpene and terpenoid biosyntheses are described in this encyclopedia, and we rarely describe conformational manipulations by the protein because that is what enzymes do. The hydrolysis of carbo cations (R3C+ + H2O  ->  R3COH  + H+ is routine. The referencing is redundant. So that is my case: I have tried to engage the editor on their talk page without any response. --Smokefoot (talk) 13:28, 10 June 2023 (UTC)
 * 1) cropped image
 * 2) acknowledge the role of linalyl pyrophosphate with link to linalool
 * 3) omit or compress discussion of conformational changes
 * 4) omit or compress description of hydrolysis of carbocation
 * 5) simplify referencing


 * I agree with Smokefoot. The version here is concise and clear, with the appropriate biosynthesis image. Zefr (talk) 14:06, 10 June 2023 (UTC)
 * I think that has misinterpreted the source reference. That article refers to a deuterium-labelling experiment designed to distinguish between two possible mechanisms: both alternatives are shown in File:Eucalyptol synthesis altered versionxyz.gif as uploaded by them but, unhelpfully, without the HR and HS of the original scheme 1 in the source. The authors of the article conclude that the right-hand alternative in their Scheme 1 is the true mechanism. Eucalyptol has a plane of symmetry, so there are not two enantiomers to discuss unless (as the source reports) one deliberately uses isotopic labelling to break the symmetry. The version of the article linked above by Zefr is fine but could be improved by a simpler diagram in .svg format, as recommended in MOS:CSDG. I'll provide my own version later. Mike Turnbull (talk) 14:36, 10 June 2023 (UTC)
 * Good pt about the product being achiral. For some reason the author wanted to show the two enantiomeric precursors though.--Smokefoot (talk) 15:34, 10 June 2023 (UTC)
 * I've added a new diagram, which I hope everyone can agree is acceptable and shows the key parts of the mechanism. Mike Turnbull (talk) 15:49, 10 June 2023 (UTC)