Talk:FNDC5

Wiki Education Foundation-supported course assignment
This article was the subject of a Wiki Education Foundation-supported course assignment, between 10 September 2020 and 15 December 2020. Further details are available on the course page. Student editor(s): Smazuera. Peer reviewers: Ncneurowiki.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 21:01, 17 January 2022 (UTC)

PGC1-alpha red link
I did a search on PGC1 and found PPARGC1A which it says is also called PGC-1alpha. However, as that article is about genetics, and not being an expert in this area, I would appreciate someone else taking a look and seeing if it would be an appropriate link. Thanks. Derek Andrews (talk) 14:31, 16 January 2012 (UTC)
 * Not an expert, but the Nature article description ("PPAR-γ co-activator-1 α") matches up with it ("Peroxisome proliferator-activated receptor gamma coactivator 1-alpha"). Not sure what molecule is the no-longer-linked image. Gaba amine (talk) 18:10, 1 July 2012 (UTC)

Nothing new in the last year?
It seems hard to believe that somebody came up with an exercise pill a full year ago, and no further research has happened since (January 2012). —Darxus (talk) 19:31, 2 January 2013 (UTC)

Disputed tag
This article is based heavily off one source and surrounding press articles and this paper in Nature casts doubt on the original research. Until someone can update the article to include this, the article needs a disputed tag. SmartSE (talk) 17:21, 4 April 2013 (UTC)


 * There is also this "our findings raise the question whether the beneficial effect of irisin observed in mice can be transferred to humans." SmartSE (talk) 17:24, 4 April 2013 (UTC)

More problems for irisin
Additional critique of the experimental basis of the irisin story is published in the journal Adipocyte, volume 2 issue 4 (Aug. 19, 2013) https://www.landesbioscience.com/journals/adipocyte/article/26082/ “Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?” by Harold P Erickson HPErickson (talk) 21:08, 21 August 2013 (UTC)
 * The above article is now at http://www.tandfonline.com/doi/full/10.4161/adip.26082 / http://doi.org/10.4161/adip.26082 --Bstard12 (talk) 19:55, 21 August 2019 (UTC)

Irisin - problems getting worse
The irisin story is continuing its downward flight. A recent paper pursued the "unusual start codon" of human FNDC5, the parent of irisin (it starts with ATA instead of the ATG that starts almost all proteins). Raschke et al (1) report that mRNA starting with the ATA is hardly translated at all. That means that humans essentially don't make FNDC5 protein, and don't have any irisin. 1. Raschke S, Elsen M, Gassenhuber H, Sommerfeld M, Schwahn U, Brockmann B, Jung R, Wisloff U, Tjonna AE, Raastad T, Hallen J, Norheim F, Drevon CA, Romacho T, Eckardt K, Eckel J. Evidence against a Beneficial Effect of Irisin in Humans. PLoS One 2013;8:e73680  — Preceding unsigned comment added by HPErickson (talk • contribs) 20:42, 8 November 2013 (UTC)

myostatin and telomeres
Was reading this August 2014 article about Cold Therapy and it mentions:
 * the newly discovered hormone irisin, which is released from muscle tissue during CT. Irisin is also released during strenuous exercise, but at a rate 4-5 times slower than with CT
 * shown to lower myostatin levels, and of course, lower myostatin means bigger muscles
 * Irisin is also involved in the "browning" of white fat. That means that hardcore intensity CT can cause white fat to start to function more like brown fat.
 * Irisin can also lengthen telomeres, which gives it a bit of an anti-aging effect, which potentially ties CT to longevity

Does anyone know of any studies confirming these claims? Ranze (talk) 01:49, 23 August 2014 (UTC)
 * I don't but google sure does.
 * Human cold-treatment-irisin link: http://pmid.us/24506871 (small human study, free fulltext for both the study article and commentary).
 * Human irisin-telomere length link: http://pmid.us/24469890.
 * Human irisin-myostatin relationship search pops up stuff mixed with Graves' disease or high-altitude climbing--Bstard12 (talk) 23:58, 14 March 2018 (UTC)

Self citing
Given the controversial nature of this topic, it is inappropriate for researchers to be citing their own publications per WP:SELFCITE. Unfortunately it appears that has already done so, although it is a review article that is highly cited so not overly problematic. Recently, added a piece of primary research which has only just been published and after it was removed then seemingly edited as an IP instead:. I will be reverting this addition and would ask that anybody involved in research on FNDC5 requests review of any additions from uninvolved editors such as myself before editing the article. SmartSE (talk) 17:36, 25 August 2015 (UTC)
 * It is unfortunate that policies more and more kill quality. As both of these additions seemed to add a bit of much needed clarity to the muddy "human irisin controversy" picture, you can perhaps add them back under your own name now so that all is fine and well? (I'd do it myself but I'm not very good at wikipedia editing).
 * Also, who on earth tagged PMC: 4593131 with "unreliable medical source"?!--Bstard12 (talk) 23:41, 14 March 2018 (UTC)