Talk:Fatty acid metabolism

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Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 21:13, 16 January 2022 (UTC)

Lipolysis?
Isn't this the same thing? Can that article be turned into a redirect without loss of information? - Taxman 19:38, Mar 28, 2005 (UTC)

Yes it should, it would go in the section "release from adipose tissue". By the way, great article. Only regulation is still mainly missing. -- Eleassar777 my talk 21:17, 3 Jun 2005 (UTC)

Hey, we found different energy yield values in the same article under metabolism and oxidation... which one is right now???

[en.wikipedia.org/wiki/fatty_acids_metabolism] [en.wikipedia.org/wiki/fatty_acids_oxidation]

last hydration heading addled
The link in this paragraph is confused. I can't quite make out what was intended, so haven't touched it. Someone should fix the link or rephrase the sentence ot make sense. 71.247.246.63 00:37, 10 June 2006 (UTC)

No ketones/ketone bodies = no fat metabolism?
Can one say that when there are no ketones or ketone bodies detectable in urine, then there definitely does no breakdown of fat from fat cells happen? --Abdull 17:24, 21 August 2006 (UTC)

Numbers in chemical equations have been changed
In this revision: 03:58, 25 November 2006 the anonymous user 69.174.67.211 has changed the numbers in some chemical equations. I have no idea which version is correct. Could someone who knows please check? Thanks. --Coppertwig 14:09, 25 November 2006 (UTC)

In this revision:  01:17, 5 December 2006  the anonymous user 152.2.36.96 has changed the number of ATP in an oxydation cycle. I have no idea which version is correct. Could someone who knows please check? Thanks. --Coppertwig 04:51, 5 December 2006 (UTC)

I rewrote the energy yield from beta-oxidation so it is now correct. I'm not sure where those numbers they had were coming from, but I just finished studying lipids in biochem for pharmacy school and double-checked with a text, so these numbers are definitely correct. Could someone please clean up the formatting though? I can't figure out why it looks screwed up. Thanks

What about Fatty Acid Synthase?
Nothing is said about the biosynthesis enzyme, fatty acid synthase. The author only talks about ACP, but without saying what this term means. The Fatty Acid Synthase and the Acyl Carrier Protein are so amazing that someone must talk about them.

WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:27, 10 November 2007 (UTC)
 * Rated as High importance on the basis of high readership.Rgdboer (talk) 22:48, 30 October 2013 (UTC)

Gallbladder
There is text indicating that People who have had their gallbladder removed due to gall stones consequently have great difficulty digesting fats. I personally know someone who has had their gallbladder removed. This does not match with observed fact; she has no such difficulty, and produces "sinkers" - poop that sinks in the toilet - indicating that fat isn't passing thru undigested, which would cause the turds to float on the surface, and has no oily discharge either. Zaphraud (talk) 02:44, 13 April 2008 (UTC)

Yes, it is understood in medicine that removing gallbladders has no deleterious effect on digestion as the liver is still able to supply bile salts in requisite amounts on an as needed basis. (165.123.88.62 (talk) 21:04, 13 September 2010 (UTC)).

Overview
I have removed captial letters from enzyme names as these are incorrect. "1. Dehydrogenation by Fatty Acyl-CoA Dehydrogenase, yielding 1 FADH2" is expecially confusing as the capitals imply a relationship between fatty acyl-CoA dehydrogenase (which, incidentally, is correct without "fatty") and FAD(H2) - the latter is flavin adenine dinucleotide, a cofactor for redox reactions (similar to NAD and NADP) --Virtualt333 (talk) 15:32, 10 May 2008 (UTC)

Hummingbird?
Why is the hummingbird photo in this article? 99.50.201.212 (talk) 01:31, 21 June 2010 (UTC)
 * That's a good question... even with the new subtext, it really didn't do anything to shed any light on the process of metabolism, so I removed it. – ClockworkSoul 03:09, 21 June 2010 (UTC)

good place for a disclaimer

 * the tissues of the central nervous system cannot use fatty acids, despite containing mitochondria, because fatty acids cannot cross the blood brain barrier into the interstitial fluids that bathe these cells.

This sounds real dark, isn't this a good place to remind people that the glycerol produced from breaking down stored triglycerides (where a lot of people will get these fatty acids) can be converted into glucose in the liver, not to mention when the muscles break down fatty acid chains they will produce ketones which CAN cross the blood-brain barrier?

This may be done elsewhere but I think any time we are harshing on fatty acid inability to do stuff we should be mentioning that it can still be done by its byproducts. 184.145.18.50 (talk) 15:54, 3 February 2016 (UTC)

misleading sentence

 * the human body stores only about 400 g of glycogen, of which 300 g is locked inside the skeletal muscles and is unavailable to the body as a whole

This is kind of inaccurate. If you do high intensity stuff which creates pyruvate faster than the mitochondria can metabolize it, it ferments into lactate and enters the bloodstream and gets built up into liver glycogen. So in that way, the glycogen "locked" in muscles CAN be available to the body as a whole, just conditional to being physically active.

IE someone sedentary could not use their muscle glycogen to fuel their brain, but someone active could use their muscle glycogen to fuel their brain via the muscleGlycogen>pyruvate>lactate>liverGlycogen transformation.

How can we rephrase this better? 184.145.18.50 (talk) 16:01, 3 February 2016 (UTC)
 * the human body stores only about 400g of glycogen, of which 300g is locked inside the skeletal muscles and is unavailable to the body as a whole unless liberated by high intensity exercise - would this be an improvement? — Preceding unsigned comment added by 94.196.123.128 (talk) 11:18, 27 August 2017 (UTC)

External links modified
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Human-centric terminology
I feel that we could improve the article by making the early sections organism-neutral and moving statements that are organism-specific (eg referring to meals, blood, liver etc) to sections that deal exclusively with that group, eg FA metabolism in animals.

I take this position as fatty acid metabolism is a biochemical process that is present in many (all?) kingdoms of life, and should be explained with this in mind. Examples that are too narrow in application can be avoided until a later section with deals with that more specifically. For example, leave mentions of organs etc until a section that deals with animal metabolism.

Here are some instances I spotted. I decided that doing a big edit without consultation would risk annoying a bunch of editors, so I thought I'd try a mention here and see what people think.
 * "Once freed from glycerol, the free fatty acids enter the blood, which transports them, attached to plasma albumin, throughout the body"
 * "Long chain free fatty acids enter the metabolizing cells (i.e. most living cells in the body except red blood cells and neurons in the central nervous system) "
 * "This is the fate of acetyl-CoA wherever beta oxidation of fatty acids occurs, except under certain circumstances in the liver."

Rohan Lowe (talk) 04:11, 19 February 2019 (UTC)

Wikidata item
Does Q910741 (the Wikidata item linked to this article) and Q14860867 describe the same thing? If so, should those items be merged? Q14860867 is described by it's Gene Ontology entry on EMBL-EBI's QuickGO and on AmiGO. int21h (talk · contribs · email) 22:01, 6 April 2019 (UTC)

Vandalism of lead sentence
Looks like I spoiled a vandalversary just in time:

 Fatty acid metabolism consists of ...

 Fatty acid metabolism consists of ...

See https://en.wikipedia.org/w/index.php?title=Fatty_acid_metabolism&oldid=928078742 — edit from November 2019; IP account since banned for other reasons

Boggles my mind how that survived for 11 months. &mdash; MaxEnt 04:34, 28 October 2020 (UTC)