Talk:Fatty liver disease

Dissolves?
Should this sentence (found in the Pathology section, first paragraph): "These vesicles are well delineated and optically "empty" because fats solves during tissue processing." read "These vesicles are well delineated and optically "empty" because fats dissolve during tissue processing." ? —The preceding unsigned comment was added by 202.63.32.81 (talk) 23:11, 23 April 2007 (UTC).

Merge
What's the difference between Fatty Liver and Non-Alcoholic Fatty Liver Disease? Should the articles be merged? If they are different, the difference should be listed here

Natural history
Fatty liver regresses in 50% and is usually due to alcohol: JFW |  T@lk  23:37, 5 November 2007 (UTC)

Merger proposal
Steatohepatitis looks like it's supposed to be the same as fatty liver to this nonspecialist. If they are, in fact, the same thing, then please make the steatohepatitis article a redirect to this one. If they aren't, then please put a note in both articles that explains the difference. Thanks, WhatamIdoing (talk) 00:21, 24 January 2008 (UTC) ---

They are definite diffrences. Fatty liver progresses to steatohepatitis with more damage. I know that fatty liver is a purely metabolic change in the liver, whereas steatohepatitis is where there is a start to structural damage. While i dont know enough to make the changes myself, i know tha they are not the same 194.81.199.55 (talk) 10:19, 13 June 2008 (UTC)


 * So what I get from your description is that they are, in fact, the same thing, with a difference only in degree. WhatamIdoing (talk) 05:27, 15 June 2008 (UTC)
 * This entire article is full of misinformation. Fatty liver is just that, an accumulation of fat within the liver. In SOME people, the liver sees the fat an a foreign material and liver inflammation occurs, THIS is what is known as non-alcoholic fatty liver disease, or non-alcoholic steato hepatitis. HUGE difference. Much evidence supports that fatty liver is due solely to a carbohydrate metabolism problem and NOT by eating fat and a defect in the liver's ability to metabolize fat improperly. Further evidence points to fructose as the main culprit. The human liver has not yet evolved enough to metabolize fructose properly. A by-product of the metabolization of fructose within the liver is a lipid droplet. And guess where it is deposited? That's right kids, in the liver. Sucrose and high fructose corn syrup metabolize into glucose and fructose. And guess what, as far as your liver is concerned, fructose is metabolized in nearly the exact same way as ethyl alcohol. And with the way high fructose corn syrup is being consumed, no wonder fatty liver is nearly an epidemic in the USA. And guess what else? Hepatitis from fatty liver, can and does progress to liver fibrosis and finally, liver cirrhosis.--98.236.11.20 (talk) 03:26, 22 March 2010 (UTC)

Fatty Liver disease, is an accumulation of predominately triglycerides within the hepatocytes (cells of the liver), this causes no inflammation, hepatocellular death, or scarring (aka Steatosis). Steatohepatitis, on the other hand is a form of liver damage. Biopsy of the liver shows steatosis, multifocal parenchymal inflamation, hepatocellular death, and sinusoidal fibrosis. The differences may seem minute but they are important. Magozar (talk) 23:03, 11 March 2009 (UTC)
 * One can have steato hepatitis without cellular necrosis and fibrosis. You are describing liver fibrosis as well as early stage cirrhosis. --98.236.11.20 (talk) 03:34, 22 March 2010 (UTC)

Tidy up
I've had a tidy up of Non-alcoholic fatty liver disease (NAFLD) and Steatohepatitis (including NAH) (noting there is also a Steatosis article). Only now come here and realised a debate... In essence Fatty liver is overall term for deposition of fat in liver disorders. As such it is the introduction article and disambiguates to more specific terms. The basic condition of fat deposition is steatosis, whereas if also then an active inflammation (a hepatitis) then termed Steatohepatitis. Now both degrees may be a result of alcohol or non-alcohol causes. This gives a 4-way split in terminology:

However to talk at length re NASH when considering just NAFLD, or active alcoholic hepatitis when considering how to manage a mildly overweight patient with insulin resistance, will cause each section of this article to constantly have to distinguish between the 4 main groupings - so to some extent dividing up overall fatty liver topic seems sensible.

The fatty liver in alcoholism is but a side issue really to alcoholic hepatitis and the overall alcoholic liver disease. Whereas fatty liver without qualification tends to be the "other causes" and neatly branches off into the Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis termed articles (later is redirected to steatohepatitis for now - I'm not sure subdividing further would be useful).

Would adding the above table (without ICD10 row) into the article (somewhere) be help ?

I've moved details specifically about NASH out of the NAFLD article, and tried to improve description in leadins to help explain what is a confusing mix of terms for similar, but not equivalent, situations. I think some information might now be moved out of fatty liver into the sub-articles of Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, but I'll let everyone have a review of those article changes first &. David Ruben Talk 00:42, 23 March 2010 (UTC)

Explaining confusing statistics
The article says the rate of fatty liver in "some countries" (which ones?) is 10-24%. But then it says that the rate in African-Americans is 24% and even higher for the white and Latino races in America. Is this true that the lowest rate among a group of Americans is equal to the highest rate amongst the general population in other countries (24%)? If so, I would recommend adding a discussion about why the incidence of fatty liver is so much higher in the US than other countries. Leastdream (talk) 16:51, 8 January 2013 (UTC)
 * I think this figure changed since then, as NAFLD is now an occurrence in approximately 25% of the population worldwide in 2017. Fatty liver, which is a superset, probably now affects an even wider part of the population. --Signimu (talk) 23:31, 29 July 2018 (UTC)

Store under proper medical name?
Just wondering - the proper medical name for this condition is Hepatic Steatosis, so should we keep this article there and have Fatty liver as a redirect to it? CharlieTheCabbie (talk) 01:53, 23 August 2014 (UTC)

Citation does not include claim
The section "Two known causes of fatty liver disease are an excess consumption of alcohol and a prolonged diet containing foods with a high proportion of calories coming from lipids" references a work which ises the word "diet" three times, none of them supporting the "prolonged" or "high proportion of calories coming from lipids" claims. I think the sentence should be struck, it sounds unfounded. JohnHarris (talk) 20:52, 8 March 2018 (UTC)
 * Yes you're correct, we updated the NAFLD article, according to the recent literature it's rather the carbohydrates than the lipids that can cause fatty liver. I have modified this article accordingly. --Signimu (talk) 18:32, 29 July 2018 (UTC)

Unclear claim at top of article
The claim "More than 90% of heavy drinkers develop fatty liver while about 25% develop the more severe alcoholic hepatitis." at the top of the article needs to clearly define "Heavy Drinker" otherwise the percentages give very little information and are potentially misleading. Golem Unity (talk) 15:53, 29 December 2021 (UTC)

Causes unclear for pediatric fatty liver disease
See https://www.washingtonpost.com/health/interactive/2023/nonalcoholic-fatty-liver-disease-kids/?utm_campaign=wp_the7&utm_medium=email&utm_source=newsletter&wpisrc=nl_the7 Jo3sampl (talk) 16:14, 3 October 2023 (UTC)