Talk:Feline infectious peritonitis/Archive 1

FIP
I created this page on July 18, 2005 in memory of Woody, a family friend who died from this awful disease. puskarm July 18, 2005 22:48 (UTC)
 * Thank you for doing this. My cat was just diagnosed. RIP Woody. Muttnick (talk) 22:57, 2 January 2021 (UTC)


 * Thank you, puskarm. In April 1995, I found a tiny, 4-week-old kitten when I was walking home from work one night, picked him up and took him home. After a couple of weeks, he began to get sick. Got colds, wouldn't eat, was losing weight, failure to thrive, etc. My vet started accusing me of abusing him. I cried so much. He started to balloon up like he had worms but he had been dewormed. He'd stay overnight at the vet's, and they'd say, "he's okay, you're the problem," but I knew I was taking GREAT care of him.
 * Thank you, puskarm. In April 1995, I found a tiny, 4-week-old kitten when I was walking home from work one night, picked him up and took him home. After a couple of weeks, he began to get sick. Got colds, wouldn't eat, was losing weight, failure to thrive, etc. My vet started accusing me of abusing him. I cried so much. He started to balloon up like he had worms but he had been dewormed. He'd stay overnight at the vet's, and they'd say, "he's okay, you're the problem," but I knew I was taking GREAT care of him.


 * So he went in for another overnight stay in the vet hospital. Then they did an x-ray and called me and said, "He has FIP, we're going to euthanize him." I told them, but I want to see him again, I want him to be held and loved one last time, I want him to see the sunlight one last time, I want him to see home one last time, you can't just kill him! So they let me take him home, it was supposed to be for a weekend but after few hours, I knew he was too sick, so I called them back and asked if I could bring him back that day. It was a Friday. He was only 4 months old, but he looked like a 2-month old.


 * I asked them how he could have gotten FIP at only 4 weeks old (because I had no other pets for him to be exposed to), and they said he probably got it in the womb. I didn't have another cat again for 9 years. It still breaks my heart to think about Boomer. He was a sweet little tuxedo cat. That vet put me through hell and over $1000 in costs before she diagnosed him, and I was a graduate student, I couldn't afford all that. On behalf of Boomer, who lived from April to August 1995, thanks for thinking of all the cats with FIP. Kelelain (talk) 13:26, 12 October 2023 (UTC)

Citation Urgently Required
"Quarantine is not necessary as FIP is not truly an infectious disease. Feline Enteric Coronavirus is shed in the feces and can be passed on to other cats, however, it is the mutated form of the virus that leads to FIP. This form is only found in macrophages and is therefore not shed and not contagious." --Potentially misleading with deadly consequences, directly contradicts the majority of sources online. Citation urgently required to offset adverse impact on accuracy and impartiality of article. — Preceding unsigned comment added by 39.34.128.141 (talk) 06:34, 11 February 2015 (UTC)

Interferon
Quote: "Feline Interferon Omega has shown great promise of putting F.I.P. into remission and can possibly increase the life span for a few more years. Feline Interferon Omega or Virbagen Omega is a product that is made by the company called Virbac.  The company that is producing the drug is currently working on it is in Europe and the drug is not for use in North America yet unless.  The only way right now that you can do to get the drug is you have to contact the company in Europe and ask for it.  The only problem with this drug is unless you have it at your veterinary clinic right when the symptoms show the the drug will not do any good because it can take up to 10 days for it to arrive from Europe and by that time if death has not yet occured it is to late to do the cat any good." [added to the article by anon]

Interferon treatment in cats is already well established for other chronic viral diseases (eg, FIV) however I've never heard or seen it proposed for use in FIP. Since the immune reaction is actually what causes fluid accumulation and ultimately death, immunostimulatatory drugs would probably be counterproductive. Typically human interferon is used (interferon alpha-2a, Roferon) while the product above sounds like recombinant feline interferon which may or may not make any difference. --Bk0 (Talk) 18:55, 3 March 2007 (UTC)


 * A researcher at the University of Glasgow cites high success rates of using: interferon treatment specifically for FIP.  Perhaps this content should therefore be rewritten and restored?  Michelel72 23:05, 24 May 2007 (UTC)

I have a very young cat who has been exhibiting many of the FIP symptoms for 2-3 weeks now, but we are not sure this is what it is. He has jaundice, weight-loss, a really high white-cell count, lethargy, but he does not have any fluid collection or neurological indications whatsoever. Maybe it's too early? I don't know... He is 8 months old, and at this point, we can only hope that it's not this awful disease. So far, it's a mystery.
 * We have sourcing for the use of interferon. If people disagree with this sourcing, they should open a new thread about it, with better sourcing.  — SMcCandlish ☏ ¢ 😼  19:30, 12 October 2023 (UTC)

Feline infectious peritonitis
We have an 11 year-old cat who has been a carrier of FIP all of her life, and is just now succumbing to it. We used to live in Italy where the disease is prevalent among stray cats, which are everywhere. When we rescued this abandoned kitten we had her checked out at an American veterinary clinic, but unfortunately she was not tested for FIP, and we had no knowledge of the disease or its prevalence in Europe. Other than a slight dry cough, she had no symptoms. After bringing her into our home in Italy, the cat we already had became gravely ill after about three months and was diagnosed and died of FIP. The kitten was tested and determined to be the carrier (both were indoor cats). The excellent Italian vet who had a great deal of experience with the disease, told us that she would always be infectious, that she would eventually succumb to it, and that the vaccine in existence (1998) was ineffective. After moving back to the States, my daughter worked for a vet who claimed utter confidence that the vaccine did work. I should have believed the more experienced vet in Italy. I'm sorry to say that we had a kitten vaccinated, waited the recommended time and brought her into our home. She was dead in three months. So I was shocked to read in the Wikipedia page on FIP that it is not contagious! I read that passage over several times, and perhaps I misunderstood the intent of the author, but that should be clarified. FIP is highly contagious. User:Kypittore.i sympathize with you.my 17 year old tuxedo cat is dying of effusive FIP.she was diagnosed 1 year ago,and she has already lived much longer than most other cats with effusive FIP,because we treated her with cyclophosphamide and pdexamethasone,which has been shown to prlong the lives of FIP patients.the vet thinks she will have 1-2 more weeks left.i will miss my poor kitty immensely.169.244.148.235 (talk) 15:04, 28 December 2009 (UTC) You take a long time to come to your point, but I agree completely: There's insufficient citation in this article in the paragraph which says "Quarantine is not necessary as FIP is not truly an infectious disease. Feline Enteric Coronavirus is shed in the feces and can be passed on to other cats, however, it is the mutated form of the virus that leads to FIP. This form is only found in macrophages and is therefore not shed and not contagious." I ahve consulted two vets (in Thailand) and three veterinary websites, and have found nobody who agrees with Wikipedia that "Quarantine is not necessary". Let's remove that paragraph, or show some VERY convincing evidence that it's true. My vet says that FIP can be transmitted in body fluids. Since unseparated cats will share food and water bowls, and cats clean themselves by LICKING their fur (and sometimes by licking one another's fur), plenty of fluids can be exchanged. We should therefore assume that Feline ***Infectious*** Peritonitis is of course contagious. Sethnessatwikipedia (talk) 10:40, 18 February 2009 (UTC)

I also question the prevailing wisdom that FIP is not contagious. From a logical perspective, the experiments that were done to test the efficacy of the FIP vaccine "challenged" the cats by giving them an oral or nasal dose of the FIP virus, and the cats became infected. So it is clearly possible for FIP itself to be transmitted. See the writeup of the studies done to evaluate the Primucell vaccine for more information. A good starting point is this: http://www.veterinarypartner.com/Content.plx?P=A&A=234&S=1&SourceID=19. Empirically, we had a cat diagnosed with FIP 40 years ago, and our vet also said that it was not contagious. Within a couple of months, however, all 5 of our other cats were showing symptoms, and we lost every one of them. Three were genetically related, the others were not. Without a really strong citation, the "Quarantine is not necessary ... not truly infectious" line should be removed. Quarantine after symptoms may be too late, but if you have other cats, it is still the best choice. Moxbox (talk) 18:15, 16 January 2011 (UTC) FIP: References


 * 1) Barlough JE, Stoddart CA: Cats and coronaviruses. J Am Vet Med Assoc 193(7):796-800, 1988.
 * 2) Mochizuki M, Furukawa H: An enzyme-linked immunosorbent assay using canine coronavirus-infected CRFK cells as antigen for detection of anti-coronavirus antibody in cat. Comp Immun Microbiol Infect Dis 12(4):139-146, 1989.
 * 3) Stoddart CA, Scott FW: Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence. J Virol 63:436-440, 1989.
 * 4) Pedersen NC: Virologic and immunologic aspects of feline infectious peritonitis virus infection. Adv Exp Med Biol 218:529-550, 1987.
 * 5) Pedersen NC: Animal virus infections that defy vaccination: Equine infectious anemia, caprine arthritis-encephalitis, maedi-visna, and feline infectious peritonitis. Adv Vet Sci Comp Med 33:413-428, 1989.
 * 6) Poland AM, Vennema H, Foley JE, Pedersen NC: Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus. J Clin Micro 34:3180-3184, 1996.
 * 7) Pedersen, NC: Personal communication.
 * 8) Foley JE, Poland A, Carlson J, et al: Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus. J Am Vet Med Assoc 210:1313-1318, 1997.
 * 9) Vennema H, DeGroot RJ, Harbour DA, et al: Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization. J Virol 64(3):1407-1409, 1990.
 * 10) Stoddart ME, Gaskell RM, Harbour DA, et al: The sites of early viral replication in feline infectious peritonitis. Vet Microbiol 18:259-271, 1988.
 * 11) Stoddart ME, Gaskell RM, Harbour DA, et al: Virus shedding and immune responses in cats inoculated with cell culture-adapted feline infectious peritonitis virus. Vet Microbiol 16:145-158, 1988.
 * 12) Scott FW: The immune response to FIP in cats. Feline Health Topics 3(4):1-3, 1989.
 * 13) August JR: Proceedings: Feline infectious peritonitis: Current concepts pp 4-13, 1989. Coronavirus infections in cats: An internist's perspective. Proceedings: Feline infectious peritonitis: Current concepts pp 4-13, 1989.
 * 14) Pedersen NC, Black JW: Attempted immunization of cats against feline infectious peritonitis, using avirulent live virus or sublethal amounts of virulent virus. Am J Vet Res 44(2):229-234, 1983.
 * 15) Ingersoll JD, Wylie DE: Identification of viral antigens that induce antibody responses on exposure to coronaviruses. Am J Vet Res 49(9):1467-1471, 1988.
 * 16) Foley JE, Pedersen NC: The inheritance of susceptibility to feline infectious peritonitis in purebred catteries. Feline Pract 24:14-22, 1996.
 * 17) Reinacher M: Diseases associated with spontaneous feline leukemia virus (FeLV) infection in cats. Vet Immunol Immunopathol 21:85-95, 1989.
 * 18) Vacirca G, Mantelli F, Ferro E, et al: Pericardial effusion with feline infectious peritonitis. Comp Anim Pract 19(8-9):25-27, 1989.
 * 19) Tamke PG, Petersen MG, Dietze AM, et al: Acquired hydrocephalus and hydromyelia in a cat with feline infectious peritonitis: A case report and brief review. Can Vet J 29:997-1000, 1988.
 * 20) Luttgen PJ: Neurologic aspects of feline infectious disease. Vet Med Reports 1(2):204-208, 1989.
 * 21) Kline KL, Joseph RJ, Averill DAJr: Feline infectious peritonitis with neurologic involvement: Clinical and pathologic findings in 24 cats. J Amer Anim Hosp Assoc 30:111-118, 1994.
 * 22) Stoddart ME, Whicher JT, Harbour DA: Cats inoculated with feline infectious peritonitis virus exhibit a biphasic acute phase plasma protein response. Vet Rec -- 17a. Sparkes AH, Gruffyd-Jones TJ, Harbour DA: An appraisal of the value of laboratory tests in the diagnosis of feline infectious peritonitis. J Am Anim Hosp Assoc 30:345-350, 1994.
 * 23) McReynolds C, Macy D: Feline infectious peritonitis. Part I. Etiology and diagnosis. Comp Cont Educ Pract Vet 19:1007-1016, 1997.
 * 24) Shelly SM, Scarlett-Kranz J, Blue JT: Protein electrophoresis on effusions from cats as a diagnostic test for feline infectious peritonitis. J Amer Anim Hosp Assoc 24:495-500, 1988.
 * 25) Ingersoll JD, Wylie DE: Comparison of serologic assays for measurement of antibody response to coronavirus in cats. Am J Vet Res 49(9):1472-1479, 1988.
 * 26) Sparkes AJ, Gruffydd-Jones TJ, Howard PE, et al: Coronavirus serology in healthy pedigree cats. Vet Rec 131:35-36, 1992.
 * 27) Hök K: Demonstration of feline corona virus (FCV) antigen in organs of cats suspected of feline infectious peritonitis (FIP) disease. APMIS 98:659-664, 1990.
 * 28) Hök K: Demonstration of feline infectious peritonitis virus in conjunctival epithelial cells from cats. APMIS 97:820-824, 1989.
 * 29) Weiss RC: A virologist's approach to treatment of feline infectious peritonitis. Proceedings: Feline infectious peritonitis: Current concepts pp 14-19, 1989.
 * 30) Weiss RC, Tiovio-Kinnucan M: Inhibition of feline infectious peritonitis replication by recombinant human leukocyte alpha  interferon and feline fibroblastic beta interferon. Am J Vet Res 49(8):1329-1335, 1988.
 * 31) Weiss RC, Oostrom-Ram T: Inhibitory effects of ribavirin alone or combined with human alpha interferon on feline infectious peritonitis virus replication in vitro. Vet Microbiol 20:255-265, 1989.
 * 32) Barlough JE, Scott FW: Effectiveness of three antiviral agents against FIP virus in vitro. Vet Rec 126:556-558, 1990.
 * 33) Weiss RC, Cox NR, Oostrom-Ram T: Effect of interferon or Propionibacterium acnes on the course of experimentally induced feline infectious peritonitis in specific-pathogen-free and random source cats. Am J Vet Res 51(5):726-733, 1990.
 * 34) Addie DD, Jarrett O: A study of naturally occurring feline coronavirus infections in kittens. Vet Rec 130:133, 1992.
 * 35) Gerber JD: New approaches to feline infectious peritonitis prevention. Proceedings: Feline infectious peritonitis: Current concepts pp 20-23, 1989.
 * 36) Christianson KK, Ingersoll JD, Landon RM, et al: Characterization of a temperature sensitive feline infectious peritonitis coronavirus. Arch Virol 109:185-196, 1989.
 * 37) Scott FW, Corapi WV, Olsen CW: Evaluation of the safety and efficacy of Primucell-FIP vaccine. Feline Health Topics 7(3):6-8, 1992.
 * 38) Posterino-Reeves N, Coyne MJ, Herman JG: Evaluation of the field efficacy of a temperature-sensitive feline infectious peritonitis vaccine. ACVIM Proc 12th Annual Forum, 1994, p1004.
 * 39) Hoskins JD, Taylor HW, Lomax TL: Challenge trial of a temperature-sensitive feline infectious peritonitis vaccine. ACVIM Proc 12th Annual Forum, 1994, p1005.

updated 7/27/01

Marty
Marty the cat died due to this. :( If this has a cure, he wouldn't die! — Preceding unsigned comment added by 118.68.45.217 (talk) 09:06, 3 November 2012 (UTC)

External links modified
Hello fellow Wikipedians,

I have just added archive links to 1 one external link on Feline infectious peritonitis. Please take a moment to review my edit. If necessary, add after the link to keep me from modifying it. Alternatively, you can add to keep me off the page altogether. I made the following changes:
 * Added archive https://web.archive.org/20140430082553/http://hopeforfip.org:80/ to http://www.hopeforfip.org

When you have finished reviewing my changes, please set the checked parameter below to true to let others know.

Cheers.—cyberbot II  Talk to my owner :Online 19:53, 13 February 2016 (UTC)

FIP
I have been volunteering/working for a vet for years and FIP is one of the most highly contagious diseases we see. It can be spread through all bodily fluids, including saliva, meaning that sharing food and water or grooming each other can be deadly for cats without the disease. It is extremely important that infected cats be quarantined. This is the only way to ensure that no healthy cats will come into contact with this disease. — Preceding unsigned comment added by Faulhnhm (talk • contribs) 13:53, 5 October 2018 (UTC)

FIP :(
My cat James died of FIP 😭😭😭😭😭 RIP you were an amazing little kitten Chicken chicken nugget (talk) 17:45, 31 March 2020 (UTC)


 * I'm so sorry for your loss. I bet it still hurts, over 3 years later. I lost my kitten, Boomer, who was 4-months-old, in 1995, from FIP. It still hurts because of how much he suffered. Those sweet little babies don't deserve to suffer like that. I know James will remember the love you gave him. Kelelain (talk) 13:39, 12 October 2023 (UTC)

Treatment/Prognosis
How should the summary inset be modified to account for GS-441524? It is known to be effective, so stating FIP is untreatable and always fatal is simply false. It would also be disingenuous to imply it has an approved treatment that is generally available, though. — Preceding unsigned comment added by 2601:191:8580:57E0:71AA:DCF0:2F53:E674 (talk) 17:16, 13 September 2020 (UTC)