Talk:Fibrous dysplasia of bone

Suggested
Suggested template for Orthopaedic Conditions (see Talk:Orthopedic surgery) is Name Definition Synonyms Incidence Pathogenesis Pathology Stages Classification Natural History/Untreated Prognosis Clinical Features Investigation Non-Operative Treatment Risks of Non-Operative Treatment Prognosis following Non-Operative Treatment Operative Treatment (Note that each operations should have its own wiki entry) Risks of Operative Treatment Prognosis Post Operation Complications Management Prevention History --Mylesclough 05:38, 8 October 2005 (UTC) worst idea ever!

I don't agree with merging this page with Cherubism which is a specific genetic condition chiefly affecting the face whereas Fibrous Dysplasia is a widespread condition. McCune-Albright syndrome has different genetics. --Mylesclough 06:15, 20 October 2005 (UTC)

I think that if articles can be dedicated to specific record albums, instead of appearing solely on the arists page, than this article deserves to reamain independent. beyond that, the didease is so complicated, that it would be a severe digression to try and include it into a broader category of dieases.

-spencer

I have Fibrous dysplasia and I find it insulting that you would merge two genetic conditions that have nothing to do with eachother into one page. If you do this you may as well combine the Apple and orange page. -Michael

I have Fibrous Dysplasia and it sucks. Scientists working on Cancer and AIDS... they need to work on Fibrous Dyssplasia. They could probably cure it,but they don't have enough time. -The weird kid who limps and takes pain pills.

Are they even the same condition?
My first thought would be, are they even the same condition. From reading the above comments, it appears to be quesitonable. do not merge if that is the case. Roodog2k 20:09, 23 April 2006 (UTC)
 * They are not the same. Do not merge. - Dozenist  talk  16:10, 15 October 2006 (UTC)

According to Dr. Collins (et. al.) of the National Institute of Health (USA), the diseases ARE directly related. MAS and FD both incur the mutation of the protein Gsα (gene:GNAS). If this cell mass remains contained within the sketetal tissue during fetal development, FD occurs. If the mass proliferates to other organs (skin, endocrine organs, etc.), Macune-Albright Syndrome is developed. The mutant Gsα triggers anomolies such as cafe au lait spots and precocious puberty in the host organ.

So the same mechanism does, in fact, trigger both conditions. As such, the article is valid. By the way, my daughter suffers from this disease as well.

Collins' acknowledgements: NIH FD Studies – Pam Robey, Paolo Bianco, Shlomo Wientroub; NIH collaborators – Penelope Feuillan, Leopold Weinstein, Natasha Cherman, Jaime Brahim, John Butman,Ed FitzGibbon, Jeff Kim, Scott Paul, Clara Chen,Tom Shawker, Arabella Leet

12.1.210.225 (talk) 13:18, 4 March 2008 (UTC)Morgan, Joseph