Talk:Fluconazole

Apo-Fluconazole
fluconazole during clinical studies was not shown to be effective in treating onchomycosis. that statement is not saying that there was 0% success in fluconazole during those clinical studies. you are one of the lucky few who had successful treatment. the statement is said for legal/insurance purposes.Henryofchang (talk) 17:56, 20 October 2009 (UTC)

"The efficacy of fluconazole in the treatment of onchomycosis (fungal infection of the nails) has not been demonstrated." I was treated with Apo-Fluconazole for onychomycosis, and it would seem that it works fine. Although I don't have any medical experience, I was wondering if someone would comment on this statement for me. Schnarr 01:48, 20 April 2006 (UTC)

I had phimosis and my doctor prscribed Fluconazole as one of the medicines... I am wondering if dealing with a possible fungal infection can stop the preputial ring from forming... please give me some feedback if you have had this problem and how it was solved.. Brian (brianmatambo@gmail.com)

I was surprised by the assertion that it is only very slightly soluble in water. When I used fluconazole in the laboratory it was reasonably soluble in water - and indeed I think this was one of the advantages of fluconazole over ketoconazole.. which IS very sparingly soluble in water. I am certain one can dissolve 5mg/ml of fluconazole in water at room temperature - which is not bad. Phil Scrutinator (talk) 20:07, 15 March 2008 (UTC)

Viofar Ltd. - Fuxilidin(R)
Should we make a list of brand names? That might be useful for searching, if the product's brand name is known but not the ingredient. The brand sold on the Greek market is Fuxilidin by Viofar Ltd. -- Zeptomoon (talk) 14:37, 15 November 2008 (UTC)

Possible Error in Drug Dosage Information
The article states: "Dosage varies with indication and between patient groups, ranging from: a two-week course of 150 mg/day for vulvovaginal candidiasis,." (emphasis mine)

I have found no drug information sheet, website, or medical provider that would agree with that statement. The most I have seen recommended for Vulvovaginal Candidiasis or Candidal Balanitis is one single dosage of Fluconazole (150mg), then a possible 2nd and 3rd dosage 3 and 6 days later respectively for severe or recurring infections (a medical provider and friend has suggested a dosage of one 150mg tablet followed by a 2nd and final dose 48 hours later).

Given the possibility of several serious, albeit rare side effects of this drug, I thought it wise to bring it to your attention. As I understand it, taking 150mg/day for two whole weeks unnecessarily would only increase the possibility of these adverse effects.

I am not a doctor, I am a patient. I considered following the dosage information offered on this webpage until I read 8 other webpages regarding this drug, each one recommending one Single-Dose tablet of Fluconazole 150mg for the said infections. There are cases where the recommended 150 mg/day for two weeks is justified, and even surpassed (eg. for cryptococcal menengitis and others), but not for Vaginal Yeast infections ...not even for severe or recurring ones.

Below are some of the websites I have visited. Thank you for your time, and thank you for the information. Despite my lengthy correction, I found the article quite helpful.

Socram321 (talk) 05:34, 27 November 2011 (UTC)

http://www.rxlist.com/diflucan-drug.htm -- "The daily dose of DIFLUCAN [Fluconazole] for the treatment of infections other than vaginal candidiasis..." (emphasis mine) http://www.biogenesis.co.za/pi-fluconazole.asp http://www.drugs.com/cdi/fluconazole-single-dose-tablets.html http://www.netdoctor.co.uk/infections/medicines/100004871.html http://www.uptodate.com/contents/patient-information-vaginal-yeast-infection

Synthesis
Synthesis picture shows wrong isomer as a result, compared to chembox structure. 70.137.130.14 (talk) 08:45, 17 December 2013 (UTC)
 * Yes, there appears to be an error in the picture. I have removed it until it can be fixed. Thanks for catching the error and reporting it here.  -- Ed (Edgar181) 12:16, 17 December 2013 (UTC)

Interactions - miss-source or miss-statement?
Under the "Interaction" sub-title, it is stated that Fluconazole is a strong inhibitor of the CYP2C19 enzyme, sourcing: https://web.archive.org/web/20161221232723/http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/6918 (archive, source 31).

The above link provides no source, but indeed in the relevant enzyme page (CYP2C19), a source is provided (#46: https://web.archive.org/web/20201104173036/https://www.fda.gov/drugs/drug-interactions-labeling/drug-development-and-drug-interactions-table-substrates-inhibitors-and-inducers) which states that Fluconazole is such (strong) inhibitor.

However, the link provided in the enzyme page CYP3A4 (source 38, here: https://web.archive.org/web/20071010053126/http://medicine.iupui.edu/flockhart/table.htm [again archived]) does not state that Fluconazole is a CYP2C19 enzyme inhibitor at all, rather a CYP2C9 (not 19) strong inhibitor (source #46, mentioned earlier, states Fluconazole is merely a moderate inhibitor thereof).

I guess I'm asking for someone who knows which is the correct source, and to update the current (#31) to it. Appreciate you taking the time to read this. 2A00:A041:2123:E400:D8EF:7508:2AC5:E213 (talk) 20:32, 23 May 2024 (UTC)