Talk:G-quadruplex

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Introduction edit
The placement and bonding to form G-quadruplexes are not random and serve very unique functional purposes. The quadruplex structure is further stabilized by the presence of a cation, especially potassium, which sits in a central channel between each pair of tetrads.[2] They can be formed of DNA, RNA, LNA, and PNA, and may be intramolecular, bimolecular, or tetramolecular. Since there was no page for tetramolecular I decided to take out the function of navigating to a link that wasn't there. Crh15j (talk) 15:33, 24 February 2017 (UTC)Crh15jCrh15j (talk) 15:33, 24 February 2017 (UTC)

sequence
d(GGTTAG) - is there a reason for this form of noting the sequence? a) as a sidenote d(sequence) probably means that it is the deoxy form of the sequence - will this be understood by the casual reader? b) why GGTTAG and not e.g. TTAGGG - it will be the Gs that form the quadruplex, so if the sequence repeats anyways, why split up the Gs? Iridos 01:40, 11 May 2007 (UTC)

a) It's the standard nomenclature, and I don't see how it could be massively improved b) There is - the enzyme telomerase, which elongates telomeres, contains an inbuilt RNA template, that adds the repeat d(GGTTAG) many times. Hence there is a starting point for the sequence. Jlh29 16:15, 7 June 2007 (UTC)


 * Sorry for the "drive-by-commenting" back then. As to a) I know it is standard for denoting "deoxy" and would not have objected in a scientific publication. For readers of an article in Wikipedia, I would not presume the same level of proficiency, though. To improve on it, one could either remove it altogether — and include a word that teleomeric repeats are found in DNA, which would imply the d, or possibly link the d( to ... perhaps deoxynucleotide — well, actually somewhere that explains what it means. Such a link might violate linking conventions, so I would prefer the first solution.
 * b) fair enough. Then it is inconsistent, though, that the introduction to Telomerase starts with: "Telomerase is an enzyme that adds DNA sequence repeats ("TTAGGG" in all vertebrates)" (the image next to it even shows a different sequence).
 * Iridos (talk) 17:46, 5 July 2011 (UTC)

repeat edits/reversion
Could 202.46.222.112 and 121.247.190.198 please cease reinserting papers - wikipedia is not pubmed, and does not need multiple listings of all papers published by their group! If they would like to suggest a change, can they discuss it here first.

Potential functions
Could anyone write a few lines on what these structures might actually do? At least hypothetical ideas. --David Munch (talk) 12:38, 22 September 2011 (UTC)
 * I've added a (very) brief starting point, which I intend to improve upon over the next few weeks/months Sarahburge (talk) 17:40, 30 November 2011 (UTC)

Monovalent cations
I removed the word "monovalent" from the introductory paragraph; quadruplexes can happily form with divalent cations; calcium and strontium cations have both been seen in quadruplexes. Sarahburge (talk) 17:31, 7 November 2011 (UTC)

Possible source

 * Chris857 (talk) 01:19, 21 January 2013 (UTC)
 * Chris857 (talk) 01:19, 21 January 2013 (UTC)

Hoogsteen Hydrogen Bonding
I think this should be more detailed. There is an excerpt that I found from a research article that states the following: "The building blocks of G-quadruplexes are G-quartets that are formed through a cyclic Hoogsten hydrogen-bonding arrangement of four guanines with each other. The planar G-quartets stack on top of one another forming four-stranded helical structures. G-quadruplex formation is driven by monovalent cations such as Na+ and K+, and hence physiological buffer conditions favour their formation" Sydharrington (talk) 21:58, 16 February 2017 (UTC)

g-quadruplex location
These structures are four stranded and occur naturally in nature. They are normally located near the ends of the chromosomes or the better known as the telomeric regions and in transcriptional regulatory regions of multiple oncogenes.

Han, Haiyong (2000). "G-quadruplex DNA: a potential target for anti-cancer drug design". TiPS. 21: 136–142 – via Google Scholar.

-Joshua Tijerino, Peter Turner, Logan Turner, Nicolas Guevara