Talk:GABA receptor

Chloride influx
It's not entirely obvious that binding of GABA(a) results in increased postsynaptic chloride influx which makes neurons less susceptible to excitation. Not sure who wrote that part so I won't modify but should be fairly straightforward.. — Preceding unsigned comment added by 74.92.162.238 (talk) 22:20, 11 January 2012 (UTC)

User friendly?
This article reads like something that was pulled from the middle of a textbook or a review article on GABA receptors. When I began reading this, it felt as if I had walked into the middle of a upper-level university lecture on GABA receptors. There should at least be an introductory paragraph that introduces some basic concepts, or at least links to them.

Agreed, wayyy too technical for the general public to be reading from an online generalized encyclopedia

Ditto. —Preceding unsigned comment added by 65.112.199.2 (talk) 21:38, 3 June 2010 (UTC)

I don't care if changes have been made, to the lamen this article makes no sense what so ever, what does a GABA receptor do?Muleattack (talk) 01:59, 21 August 2011 (UTC)


 * Yes, maybe it should start by saying where GABA receptors are (in the brain?) and how they are part of a family of other receptors that control x, y and z. Do GABA receptors affect our mood? Do they influence the release of hormones? Ljsense (talk) 20:23, 6 October 2022 (UTC)

I agree as well! My question is the same as above! What does a GABA receptor do?? cause that's the answer I was looking for! — Preceding unsigned comment added by 24.56.24.28 (talk) 15:33, 4 September 2011 (UTC)

Not all GABA channel permit chloride influx. EXP-1 is an invertebrate, excitatory GABA gated sodium channel — Preceding unsigned comment added by 192.197.54.24 (talk) 20:58, 14 March 2012 (UTC)

Proposed Merge
Does anyone else think we should merge the GABA A B and C receptor pages? The other articles are very short so I think there is a strong argument for doing this. Fibrosis 14:36, 13 August 2006 (UTC)

Re: User friendly... definitely needs improvement
I completely agree with the other commant about it feeling like walking into a university level lecture. (Incidentally I'm a university level med student 3 days from a pharmacology final at 4:30am). Please, this page needs to be made into simpler english, and I'd do it but I'm afraid it'd be all wrong. I also have no idea how to tag it as needing improvement. Squiggle 20:34, 3 March 2007 (UTC)
 * I hate to do this, but the article is in dire need of cleanup. I'll tag it accordingly (you can find such tags here) and raise attention to it on relevant WikiProjects. Good luck! Fvasconcellos 21:02, 3 March 2007 (UTC)
 * I've outlined it - it should be clearer now. --Arcadian 21:40, 3 March 2007 (UTC)

I've done a little editing myself, too. This article could use a diagram of the receptor subtypes. (kinda like this) Most importantly, this article is lacking any info on GABAD. -- Scientizzle 00:06, 4 March 2007 (UTC)

Distribution of the receptors?
Something this article should address is where these receptors are located (pre/post- synaptic, anatomic regions with a greater distribution). This article needs some more fleshing out. You should explain the significance of the multiple sites on the GABAa receptors.

Purge references to GABAC
As of recently, IUPHAR has depreciated the use of the term GABAC. Quite rightly so, and this was just a catch all for non GABA-A non GABA-B receptors, and doesn't belong in the age of moleuclar pharmacology. To quote from the IUPHAR review "[all of the evidence] led to the decision of the Nomenclature Committee of IUPHAR to designate the GABA rho receptors as part of the GABAA-R family and to recommend against the use of the term GABAC receptor."

International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Olsen RW, Sieghart W. Pharmacol Rev. 2008 Sep;60(3):243-60

I'm going to come back when I'm less busy and remove references to the GABAC receptor, apart from to mention the fact that it is a historical curiosity Bilz0r (talk) 21:17, 12 May 2009 (UTC)

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GABA receptor
Voice 2405:204:A408:C770:6989:C57E:1176:4591 (talk) 15:03, 14 March 2022 (UTC)