Talk:Genetics of Down syndrome

Meiosis 1 or 2?
There is something I don't understand, how would you, for instance, distinguish between a Down syndrome caused at the stage 1 of meiosis and the same at stage 2 of meiosis ? Thanks. XApple (talk) 14:23, 26 November 2007 (UTC)

Error in 'Possible Gametes from Translocation' Diagram?
How can a gamete contain both a 14/21 translocation and chromomsome 14 at the same time? Also, how can a gamete contain C21 on its own? —Preceding unsigned comment added by 78.16.154.143 (talk) 19:43, 28 November 2009 (UTC)

External links modified
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Moved to talk
I moved this addition to the talkpage:

It is theoretically possible that normal mothers of children with Down Syndrome may be chromosomal mosaics and that the abnormal chromosomal cells are in the ovarian tissue. The ova produced by such individuals contain trisomic cells and result in trisomic offspring. This type of mosaicism would not be detectable in cytological studies of the usual tissues. Epidemiology of mongolism

The wording is off ("normal" mothers?). The link does not work. Polygnotus (talk) 01:25, 25 June 2024 (UTC)

Ah, I think the link should be https://archive.org/details/epidemiologyofmo00lili but that is a book from 1969 and not a reliable source. Polygnotus (talk) 01:29, 25 June 2024 (UTC)

We can't use a book that old (55 years...) for a medical claim. We have to follow WP:MEDRS. Better newer sources exist. Polygnotus (talk) 01:55, 25 June 2024 (UTC)