Talk:Genistein

Not so shiny
Why none even bothers to even mention the bad side pf phytoestrogens in males infants and pre-menstrual women. it seems that "reduce cholesterol prevent cancer and anti oxidative properties are found in damm near everything that some shady "health experts" advertise..... pfft. I can't belive wikipedia has fell for this medieval mentality instead of finding out the truth.

Oh great Anonymous bearer of The Truth, if you would like more information on the potential health risks of Phytoestrogens, you could start by reading the page on phytoestrogen under the Health Risks section. --Idurey 19:29, 24 May 2007 (UTC)

Any company that tries to market soy as preventing cancer will get in trouble with the FDA; the FDA has not nor will ever award soy GRAS status. Actually, soy causes cancer as will be seen in the phytoestrogen article Idurey references. --Nibblet 00:11, 1 June 2007 (UTC)

Regarding the statement on animal experiments carried out by NCI scientists on Genistein. There are other articles that show Genistein causes uterine adenocarcinomas in older animals through epigenetic mechanisms, see: "Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein." Tang WY et al 2008 pmid=18669593 --Amosfolarin (talk) 10:34, 7 August 2008 (UTC)

What cancer is elevated somewhere in the world that is associated with high genistein consumption? Nicmart (talk) 10:25, 3 March 2021 (UTC)

Genistein vs. phytoestrogens
This article makes quite a few seemingly contradictory statements. This may be in part because of conflicting research results, but may also be because the article conflates the effects of genistein with those of phytoestrogens in general. Citations to research directly related to genistein are badly needed, and comments about phytoestrogens in general should probably be taken out and/or moved to the article on phytoestrogens.-- Ed (Edgar181) 13:09, 12 April 2008 (UTC)

Tamoxifen
That's in one of my quotations and it begs the question: "Who paid for your research?", and "Is it replicated?". BrewJay (talk) 21:56, 27 May 2008 (UTC)

Coherence
I'm not sure that I can paint a coherent picture of what genistein does in a summary. Hmmm. Maybe I can just scan all the headlines in a pubmed search, probably about 6000 hits or three hours. BrewJay (talk) 22:58, 28 May 2008 (UTC)

Snipping
I removed "what leads to many, frequently exclusive or paradoxical conclusions" in "Molecular" section. This phrase is confusing and might be taken as either opinion or unsupported/undocumented, or both. It would be good of someone to take a run at laying out the controversies alluded to on this talk page in the actual article. Here.it.comes.again (talk) 08:57, 22 September 2011 (UTC)

assorted minor problems
Acetylated compounds - wighteone is not acetylated! Ref. 24, 43, & 59 are duplicates. Wording problems: Molecular function - that should presumably be proOxidative and inhibiting it aT higher. Tyrosine kinase inhibitor - is tyrosine kinase inhibitION. Redox-active - free radicals poisonS. Cancer links -, instead of .; after radio-therapy and no , after although. Carcinogenic - whICH may lead to leukemia. Ref. 9 - shouldn't that be fLavanones etc.? Ref. 16 - obviously gamma instead of g.

Blacklisted Links Found on Genistein
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Two newer studies show benefits towards Testosterone levels and testicular weight.
Quite a few newer studies than the 1998 one which was cited as destroying testes have surfaced in my research. (the 1998 study does not even mention dosages in the excerpt, making it useless ihmo) They have the opposite claim, that Genistein may help protect testicles from the deleterious effect of estrogen when administered in moderate quantities:

http://www.researchgate.net/publication/236869307_Effects_of_isoflavones_on_testicular_weight_and_testosterone_secretion_in_ISA_Brown_roosters

http://www.hindawi.com/journals/bmri/2014/598630/

http://www.ncbi.nlm.nih.gov/pubmed/12840195

http://dbzach.fst.msu.edu/publications/pdf/Fielden-FoodChemTox41(4)447-54,2003.pdf

This may reveal a possible smear-campaign attempt against isoflavones in general. — Preceding unsigned comment added by NeferiusNexus (talk • contribs) 04:47, 8 October 2015 (UTC)

High doses
It reads: “ In high doses it was found to be strongly toxic to normal cells.” This is dog whistle to some people. Could someone include the real world human dose calculation? Ounces of tofu a day? Pounds? Tons? Nicmart (talk) 10:28, 3 March 2021 (UTC)