Talk:Glimepiride

What?
This article is half gibberish and half broken english. Someone who actually understands this needs to fix it. AeoniosHaplo 19:16, 18 May 2007 (UTC)

Not all criticism is useful. This article is perfectly clear as far as it goes, but contains insufficient data on the drug's development, interactions, side-effects, and contraindications, and there should be some discussion of its use in combination with other drugs. This is particularly important since many physicians employ a combination therapy (e.g., a sulfonylurea and metformin) and since many type II diabetics also have cardiovascular or renal problems. In this context, more information concerning the interaction with thiazides would be especially salient. — Preceding unsigned comment added by JIMPARKS (talk • contribs) 20:09, 17 December 2011 (UTC)

Half-life
What's the biological half-life? The article says it's 5 hours. My primary care physician said it's closer to 9-10 hours. I think the article could be improved with a citation to appropriate research -- especially if 5 hours is wrong. I understand that the reality could be more complicated than simple exponential decay. Glimepiride might go through several stages in the body, and the ingested form might have a half-life of 5 hours but half of a subsequent form could still be present 10 hours later. Thanks, DavidMCEddy (talk) 22:39, 30 September 2015 (UTC)