Talk:Glomerular filtration rate/Archive 1

Crude estimates
It seems very crude to estimate GFR without bothering to measure urine production rate. But it seems common. The article should have information about the relative accuracy and variation of the various estimates.-69.87.204.50 11:56, 16 July 2007 (UTC)


 * Urine production rate is a function of hydration (ie how much excess fluid needs to be got rid of) and can remain normal up to end stage failure. What I think you mean is filtering rate, using total urinary elimation compared to the blood levels.
 * Hence if x of creatinine is in a 24hour urine volume y, then the same blood filtering occured by the kidneys as if the person had drunk far more water and had x creatinine in 2y volume of urine. In both the filtered & eliminated creatinine is the same although the urine production rate was higher in the second case (as there would have occured less reabsorption of water following on from the glomeruli in the Loop of Henle).
 * But I agree discussion of relative accuracy would be useful. As some initial links About eGFR and Information to support eGFR reporting both from UK Renal Association should provide a good start for details on the MDRD eGFR that has been imposed upon us in the UK without consultation. David Ruben Talk 18:51, 16 July 2007 (UTC)

MDRD calc
At first, I was pleased to see the MDRD formula. Then I realized how hard it would be to carry out the calculation, with negative decimal powers. Then I saw the MDRD calc link at the bottom, http://www.pace-med-apps.com/GFR%20Calc.aspx But it turns out that link page has many problems. The formulas are not given, and the way they behave does not seem to correspond to the formulas in the article. So, if anyone finds a better online calc for MDRD, please add it to the article! -69.87.200.138 01:29, 17 July 2007 (UTC)

Cr-51 EDTA
Adding a section on GFR measurements using Cr-51 labelled EDTA would give the article more credibilty. —Preceding unsigned comment added by Ph73nt (talk • contribs) 15:55, 18 October 2007 (UTC)

Glomerular Filtration Rate
The current GFRs cited: are technically incorrect. According to my copy of the Merck Manual, about.com, and the online Merck Manual's article on creatinine clearance, those values need to be adjusted for "a 'standard' body size with a surface area of 1.73 meters2." So, I'm changing the GFRs to the values cited by Merck: Thebellmaster1x 17:56, 15 June 2007 (UTC)
 * Males: 97 to 137 ml/min.
 * Females: 88 to 128 ml/min.
 * Males: 70 ± 14 mL/min/m2
 * Females: 60 ± 10 mL/min/m2

The above is correct, however in my experience normal GFR is quoted ml/min/1.73m2 to allow ease of comparison to estimated or measured GFRs from individuals, as body surface area is not routinely measured. The above values should be reverted and the units simply changed to ml/min/1.73m2. —Preceding unsigned comment added by 121.209.21.193 (talk) 06:54, 20 October 2007 (UTC)