Talk:Glutamate decarboxylase

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This article was the subject of a Wiki Education Foundation-supported course assignment, between 4 September 2018 and 20 December 2018. Further details are available on the course page. Student editor(s): Bigrocksmall. Peer reviewers: Emandems1, ApexofAdharma.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 22:28, 16 January 2022 (UTC)

Untitled
I added content about the involvement of GAD67 in schizophrenia. Specifically, I added an explanation that may account for why GAD67 levels are lower in schizophrenics and how this molecular alteration may contribute to the working memory impairments often observed in patients. — Preceding unsigned comment added by Jgalvin2015 (talk • contribs) 15:48, 7 December 2014 (UTC)

The following text on L-Glutamic acid decarboxylase was replaced with a redirect to this article:

L-Glutamic acid decarboxylase (GAD) is an enzyme necessary for the synthesis of the inhibitory neurotransmitter GABA in GABAergic nerve endings. In the presence of pyridoxal phosphate as cofactor, the enzyme decarboxylates glutamate to yield GABA and CO2. GAD exists in two isoforms encoded by two different genes. These isoforms are GAD65 and GAD67 with molecular weights of 65 and 67 kDa, respectively. GAD67 is only present in GABAergic neurons and so can be used as a marker.

In experimental animals, administration of drugs to inhibit GAD invariably leads to epileptic seizures. People with diabetes mellitus type 1 often have autoantibodies against GAD65, leading to speculation about the role these antibodies play in the development of diabetes mellitus.

GAD transfer gene therapy for Parkinson's
Interesting theme, could be investigated and some info added in the article. (, ; also some media articles). CopperKettle 12:14, 5 July 2007 (UTC)

Perhaps someone could add something about Stiff Person Syndrome and high anti-GAD antibodies. — Preceding unsigned comment added by 98.127.162.136 (talk) 04:31, 22 September 2011 (UTC)

GAD Regulation
Added information about the regulation and synthesis of GAD65 and GAD67 to help show the differences between these two proteins and how differences in their regulation can highlight differences in their function. — Preceding unsigned comment added by Cbavley (talk • contribs) 19:46, 2 May 2013 (UTC)

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