Talk:Gramine

unsourced
moved here per PRESERVE

Gramine is used mostly in synthetic organic chemistry as a starting material for tryptophan syntheses.
 * Uses

All reactions of gramine follow the same general reaction scheme. Gramine is reacted with a strong electrophile, such as methyl iodide, to form the quaternary ammonium salt 2. The ammonium salt will undergo a Hofmann elimination or Michael addition to give the very active intermediate 3, which can accept a wide range of nucleophiles to give the desired product 4.


 * [[Image:Gramine Retromichael Addition Scheme.png|500px|Retromichael addition of gramine]]

It did say that gramine has use in the synthesis of Bucindolol as well as laboratory man-made Indole-3-carbinol oligomers.

-- Jytdog (talk) 02:47, 21 September 2017 (UTC)